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Source: Stroke
Therapy: Statin Therapy
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Total 59 results found since Jan 2013.
Lipid-Lowering Agents and High HDL (High-Density Lipoprotein) Are Inversely Associated With Intracranial Aneurysm Rupture Clinical Sciences
Conclusions—Higher HDL values and the use of lipid-lowering agents are significantly inversely associated with ruptured intracranial aneurysms.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Anil Can, Victor M. Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A. Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T. Weiss, Rose Du Tags: Risk Factors, Cerebral Aneurysm Original Contributions Source Type: research
Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes Clinical Sciences
Conclusions—LDL cholesterol lowering is likely to prevent large artery atherosclerosis but may not prevent small artery occlusion nor cardioembolic strokes. High-density lipoprotein cholesterol elevation may lead to benefits in small artery disease prevention. Finally, triglyceride lowering may not yield benefits in ischemic stroke and its subtypes.
Source: Stroke - March 26, 2018 Category: Neurology Authors: George Hindy, Gunnar Engstrom, Susanna C. Larsson, Matthew Traylor, Hugh S. Markus, Olle Melander, Marȷu Orho–Melander Tags: Lipids and Cholesterol, Risk Factors, Ischemic Stroke Original Contributions Source Type: research
Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence Clinical Sciences
Conclusions—The composite risk of stroke and transient ischemic attack reduced in the postrandomized LDL cholesterol level of 80 to 100 mg/dL after adjusting for statin usage.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00221104.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Naohisa Hosomi, Kazuo Kitagawa, Yoji Nagai, Yoko Nakagawa, Shiro Aoki, Tomohisa Nezu, Tatsuo Kagimura, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masayasu Matsumoto Tags: Lipids and Cholesterol, Secondary Prevention, Treatment Original Contributions Source Type: research
Letter by Scheitz et al Regarding Article, “Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke: ASSORT Trial (Administration of Statin on Acute Ischemic Stroke Patient)” Letter to the Editor
Source: Stroke - February 26, 2018 Category: Neurology Authors: Jan F. Scheitz, Kennedy R. Lees, Matthias Endres Tags: Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Neuroprotectants Letters to the Editor Source Type: research
Response by Yoshimura et al to Letter Regarding Article, “Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke: ASSORT Trial (Administration of Statin on Acute Ischemic Stroke Patient)” Letter to the Editor
Source: Stroke - February 26, 2018 Category: Neurology Authors: Shinichi Yoshimura, Kazutaka Uchida, Takeshi Morimoto Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Letters to the Editor Source Type: research
Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness Clinical Sciences
Conclusions—The usual Japanese dose of pravastatin significantly reduced the progression of carotid IMT at 5 years in patients with noncardioembolic stroke.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00361530.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Masatoshi Koga, Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Shiro Aoki, Tomohisa Nezu, Naohisa Hosomi, Tatsuo Kagimura, Hideki Origasa, Kenji Kamiyama, Rieko Suzuki, Toshiho Ohtsuki, Hirofumi Maruyama, Kazuo Kitagawa, Shinichiro Uchiyam Tags: Risk Factors, Secondary Prevention, Ultrasound, Atherosclerosis Original Contributions Source Type: research
Statin Treatment in Patients With Intracerebral Hemorrhage Comments and Opinions
Source: Stroke - December 22, 2017 Category: Neurology Authors: Matthias Endres, Christian H. Nolte, Jan F. Scheitz Tags: Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Comments and Opinions Source Type: research
Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks Clinical Sciences
Background and Purpose—Established risk factors do not fully identify patients at risk for recurrent stroke. The SPARCL trial (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) evaluated the effect of atorvastatin on stroke risk in patients with a recent stroke or transient ischemic attack and no known coronary heart disease. This analysis explored the relationships between 13 plasma biomarkers assessed at trial enrollment and the occurrence of outcome strokes.Methods—We conducted a case–cohort study of 2176 participants; 562 had outcome strokes and 1614 were selected randomly from those without outcom...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Peter Ganz, Pierre Amarenco, Larry B. Goldstein, Henrik Sillesen, Weihang Bao, Gregory M. Preston, K. Michael A. Welch Tags: Biomarkers, Proteomics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack Clinical Sciences
Conclusions—Statin use was not associated with an increased risk of ICH among patients with a previous history of IS/TIA.
Source: Stroke - November 27, 2017 Category: Neurology Authors: David Gaist, Larry B. Goldstein, Lucia Cea Soriano, Luis Alberto Garcia Rodriguez Tags: Secondary Prevention, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Statins for Neuroprotection After Acute Ischemic Stroke Editorial
Source: Stroke - October 23, 2017 Category: Neurology Authors: Peter Kelly, Shyam Prabhakaran Tags: Ischemic Stroke, Neuroprotectants Editorials Source Type: research
One-Year Outcomes After Minor Stroke or High-Risk Transient Ischemic Attack Clinical Sciences
Conclusions—Contemporary secondary stroke prevention strategies based on thorough diagnostic evaluation may contribute to the low subsequent vascular event rates observed in real-world clinical practice in Korea.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Byung-Chul Lee, Kyung-Ho Yu, M Tags: Quality and Outcomes, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Randomized Controlled Trial of Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions—Our randomized trial involving patients with acute ischemic stroke and dyslipidemia did not show any superiority of early statin therapy within 24 hours of admission compared with delayed statin therapy 7 days after admission to alleviate the degree of disability at 90 days after onset.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02549846.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Shinichi Yoshimura, Kazutaka Uchida, Takashi Daimon, Ryuzo Takashima, Kazuhiro Kimura, Takeshi Morimoto, on behalf of ASSORT Trial Investigator* Tags: Clinical Studies, Lipids and Cholesterol, Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke Clinical Sciences
Conclusions—After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo Tags: Secondary Prevention, Compliance/Adherence, Ischemic Stroke Original Contributions Source Type: research
Use of Statins and Outcomes in Intracerebral Hemorrhage Patients Clinical Sciences
Conclusions—Although statin use, especially continued/new use, was associated with improved intracerebral hemorrhage outcomes, this effect may merely reflect the physician’s view of a patient’s prognosis rather than a predictor of survival.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Fazeel M. Siddiqui, Carl D. Langefeld, Charles J. Moomaw, Mary E. Comeau, Padmini Sekar, Jonathan Rosand, Chelsea S. Kidwell, Sharyl Martini, Jennifer L. Osborne, Sonja Stutzman, Christiana Hall, Daniel Woo Tags: Intracranial Hemorrhage Original Contributions Source Type: research
Challenges in the Medical Management of Symptomatic Intracranial Stenosis in an Urban Setting Clinical Sciences
Background and Purpose—Since the SAMMPRIS trial (Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), aggressive medical management (AMM), which includes dual antiplatelet therapy (DAPT) and high-dose statin (HDS) therapy, is recommended for patients with symptomatic intracranial atherosclerotic disease. However, limited data on the real-world application of this regimen exist. We hypothesized that recurrent stroke risk among patients treated with AMM is similar to the medical arm of the SAMMPRIS cohort.Methods—Using a prospective registry, we identified all patients adm...
Source: Stroke - July 24, 2017 Category: Neurology Authors: Rajbeer S. Sangha, Andrew M. Naidech, Carlos Corado, Sameer A. Ansari, Shyam Prabhakaran Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Stenosis, Vascular Disease Original Contributions Source Type: research
