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Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity Brief Report
Background and Purpose—Brain arteriovenous malformation (bAVM) is an important risk factor for intracranial hemorrhage. Current therapies are associated with high morbidities. Excessive vascular endothelial growth factor has been implicated in bAVM pathophysiology. Because soluble FLT1 binds to vascular endothelial growth factor with high affinity, we tested intravenous delivery of an adeno-associated viral vector serotype-9 expressing soluble FLT1 (AAV9-sFLT1) to alleviate the bAVM phenotype.Methods—Two mouse models were used. In model 1, bAVM was induced in R26CreER;Eng2f/2f mice through global Eng gene deletion and ...
Source: Stroke - April 24, 2017 Category: Neurology Authors: Wan Zhu, Fanxia Shen, Lei Mao, Lei Zhan, Shuai Kang, Zhengda Sun, Jeffrey Nelson, Rui Zhang, Dingquan Zou, Cameron M. McDougall, Michael T. Lawton, Thiennu H. Vu, Zhijian Wu, Abraham Scaria, Peter Colosi, John Forsayeth, Hua Su Tags: Angiogenesis, Animal Models of Human Disease, Gene Therapy Brief Reports Source Type: research

Myoblast-Mediated Gene Therapy Improves Functional Collateralization in Chronic Cerebral Hypoperfusion Basic Sciences
Conclusions— Myoblast-mediated VEGF supplementation at the target site of an EMS could help overcome the clinical dilemma of poor surgical revascularization results and provide protection from ischemic stroke.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Hecht, N., Marushima, A., Nieminen, M., Kremenetskaia, I., von Degenfeld, G., Woitzik, J., Vajkoczy, P. Tags: Cerebrovascular disease/stroke, By-pass procedures Basic Sciences Source Type: research

Intravenous Delivery of Adeno-Associated Viral Vector Serotype 9 Mediates Effective Gene Expression in Ischemic Stroke Lesion and Brain Angiogenic Foci Brief Reports
Conclusions— ssAAV9 could be a useful tool to deliver therapeutic genes to the ischemic stroke lesion or brain angiogenic foci.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Shen, F., Kuo, R., Milon-Camus, M., Han, Z., Jiang, L., Young, W. L., Su, H. Tags: Cerebrovascular disease/stroke, Gene regulation, Acute Cerebral Infarction, Gene therapy Brief Reports Source Type: research