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Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage Basic Sciences
Conclusions—LTF delivered to the ICH-affected brain by infiltrating PMNs may assist in hematoma detoxification and represent a powerful potential target for the treatment of ICH.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Xiurong Zhao, Shun–Ming Ting, Guanghua Sun, Meaghan Roy–O’Reilly, Alexis S. Mobley, Jesus Bautista Garrido, Xueping Zheng, Lidiya Obertas, Joo Eun Jung, Marian Kruzel, Jaroslaw Aronowski Tags: Translational Studies Original Contributions Source Type: research

Minocycline Effects on Intracerebral Hemorrhage-Induced Iron Overload in Aged Rats Basic Sciences
This study quantified brain iron levels after ICH with magnetic resonance imaging R2* mapping. The effect of minocycline on iron overload and ICH-induced brain injury in aged rats was also determined.Methods—Aged (18 months old) male Fischer 344 rats had an intracerebral injection of autologous blood or saline, and brain iron levels were measured by magnetic resonance imaging R2* mapping. Some ICH rats were treated with minocycline or vehicle. The rats were euthanized at days 7 and 28 after ICH, and brains were used for immunohistochemistry and Western blot analyses. Magnetic resonance imaging (T2-weighted, T2* gradient-...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Shenglong Cao, Ya Hua, Richard F. Keep, Neeraj Chaudhary, Guohua Xi Tags: Basic Science Research, Intracranial Hemorrhage Original Contributions Source Type: research

Carotid Atheroma From Men Has Significantly Higher Levels of Inflammation and Iron Metabolism Enabled by Macrophages Clinical Sciences
Conclusions—Male patients with carotid atheroma had more advanced and ruptured lesions associated with significantly higher levels of inflammatory macrophage infiltration and high iron stores in the blood and in their plaques. These findings help to understand sex differences and iron metabolism in atherosclerosis and factors related to atheroma progression.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Xi-Ming Yuan, Liam J. Ward, Claes Forssell, Nabeel Siraj, Wei Li Tags: Inflammation, Oxidant Stress, Pathophysiology, Proteomics, Atherosclerosis Original Contributions Source Type: research

Prevalence and Natural History of Superficial Siderosis Clinical Sciences
This study aimed to report the prevalence and natural history of SS in a population-based study.Methods—Brain magnetic resonance imaging scans from the MCSA (Mayo Clinic Study of Aging), a population-based study of residents 50 to 89 years of age in Olmsted County, Minnesota, were reviewed. Participants with imaging consistent with SS were identified from 2011 through 2016. An inverse probability weighting approach was used to convert our observed frequencies to population prevalence of SS. Additional data abstracted included amyloid positron emission tomography, Apolipoprotein E genotype, coexisting cerebral microbleeds...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Michael Pichler, Prashanthi Vemuri, Alejandro A. Rabinstein, Jeremiah Aakre, Kelly D. Flemming, Robert D. Brown Jr, Neeraj Kumar, Kejal Kantarci, Walter Kremers, Michelle M. Mielke, David S. Knopman, Clifford R. Jack Jr, Ronald C. Petersen, Val Lowe, Jona Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Malformations, Intracranial Hemorrhage Original Contributions Source Type: research