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Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage
CONCLUSIONS: Although in vascular smooth muscle, PDE3A mutations cause hypertension, they confer protection against hypertension-induced cardiac damage in hearts. Nonselective PDE3A inhibition is a final, short-term option in heart failure treatment to increase cardiac cAMP and improve contractility. Our data argue that mimicking the effect of PDE3A mutations in the heart rather than nonselective PDE3 inhibition is cardioprotective in the long term. Our findings could facilitate the search for new treatments to prevent hypertension-induced cardiac damage.PMID:36259389 | DOI:10.1161/CIRCULATIONAHA.122.060210
Source: Circulation - October 19, 2022 Category: Cardiology Authors: Maria Ercu Michael B M ücke Tamara Pallien Lajos Mark ó Anastasiia Sholokh Carolin Sch ächterle Atakan Aydin Alexa Kidd Stephan Walter Yasmin Esmati Brandon J McMurray Daniella F Lato Daniele Yumi Sunaga-Franze Philip H Dierks Barbara Isabel Montesinos Source Type: research

Cost-effectiveness of a Household Salt Substitution Intervention: Findings From 20,995 Participants of the Salt Substitute and Stroke Study (SSaSS)
Conclusions: Replacing regular salt with salt substitute was a cost-saving intervention for the prevention of stroke and improvement of quality of life amongst the SSaSS participants.PMID:35311346 | DOI:10.1161/CIRCULATIONAHA.122.059573
Source: Circulation - March 21, 2022 Category: Cardiology Authors: Ka-Chun Li Liping Huang Maoyi Tian Gian Luca Di Tanna Jie Yu Xinyi Zhang Xuejun Yin Yishu Liu Zhixin Hao Bo Zhou Xiangxian Feng Zhifang Li Jianxin Zhang Jixin Sun Yuhong Zhang Yi Zhao Ruijuan Zhang Yan Yu Nicole Li Lijing L Yan Darwin R Labarthe Paul Elli Source Type: research

Phosphodiesterase 3A and Arterial Hypertension.
Conclusions: The mutated PDE3A gene drives mechanisms that increase peripheral vascular resistance causing hypertension. We present two new animal models that will serve to elucidate the underlying mechanisms further. Our findings could facilitate the search for new antihypertensive treatments. PMID: 32524868 [PubMed - as supplied by publisher]
Source: Circulation - June 10, 2020 Category: Cardiology Authors: Ercu M, Markó L, Schächterle C, Tsvetkov D, Cui Y, Maghsodi S, Bartolomaeus TUP, Maass PG, Zühlke K, Gregersen N, Hübner N, Hodge R, Mühl A, Pohl B, Molé-Illas R, Geelhaar A, Walter S, Napieczynska H, Schelenz S, Taube M, Heuser A, Anistan YM, Qadri Tags: Circulation Source Type: research