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Source: Circulation
Condition: Diabetes

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Total 147 results found since Jan 2013.

Heart Failure, Saxagliptin and Diabetes Mellitus: Observations from the SAVOR - TIMI 53 Randomized Trial.
CONCLUSIONS: -In the context of balanced primary and secondary endpoints, saxagliptin treatment was associated with an increased risk for hospitalization for heart failure. This increase in risk was highest among patients with elevated levels of natriuretic peptides, prior heart failure, or chronic kidney disease. Clinical Trial Registration Information-ClinicalTrials.gov. Identifier: NCT01107886. PMID: 25189213 [PubMed - as supplied by publisher]
Source: Circulation - September 4, 2014 Category: Cardiology Authors: Scirica BM, Braunwald E, Raz I, Cavender MA, Morrow DA, Jarolim P, Udell JA, Mosenzon O, Im K, Umez-Eronini AA, Pollack PS, Hirshberg B, Frederich R, Lewis BS, McGuire DK, Davidson J, Steg PG, Bhatt DL, for the SAVOR-TIMI 53 Steering Committee and Investi Tags: Circulation Source Type: research

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus: A Scientific Statement From the American Heart Association.
of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council for High Blood Pressure Research, and Council on Lifestyle and Cardiometabolic Health PMID: 25170098 [PubMed - as supplied by publisher]
Source: Circulation - August 28, 2014 Category: Cardiology Authors: Maahs DM, Daniels SR, de Ferranti SD, Dichek HL, Flynn J, Goldstein BI, Kelly AS, Nadeau KJ, Martyn-Nemeth P, Osganian SK, Quinn L, Shah AS, Urbina E, on behalf of the American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee Tags: Circulation Source Type: research

Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke: A Population-Based Cohort Study.
CONCLUSIONS: -The risk of cardiovascular diseases and T2DM is increased across a range of organ-specific and multi-system chronic inflammatory disorders with evidence that risk is associated with severity of inflammation. Clinical management of patients with chronic inflammatory disorders should aim to reduce cardiovascular risk. PMID: 24970784 [PubMed - as supplied by publisher]
Source: Circulation - June 26, 2014 Category: Cardiology Authors: Dregan A, Charlton J, Chowienczyk P, Gulliford MC Tags: Circulation Source Type: research

Lack of Concordance between Empirical Scores and Physician Assessments of Stroke and Bleeding Risk in Atrial Fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry.
CONCLUSIONS: There is little agreement between provider-assessed risk and empirical scores in AF. These differences may explain, in part, current divergence of anticoagulation treatment decisions from guideline recommendations. CLINICAL TRIAL REGISTRATION INFORMATION: clinicaltrials.gov Identifier: NCT01165710. PMID: 24682387 [PubMed - as supplied by publisher]
Source: Circulation - March 29, 2014 Category: Cardiology Authors: Steinberg BA, Kim S, Thomas L, Fonarow GC, Hylek E, Ansell J, Go AS, Chang P, Kowey P, Gersh BJ, Mahaffey KW, Singer DE, Piccini JP, Peterson ED, on behalf of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigat Tags: Circulation Source Type: research

Warfarin Use and the Risk for Stroke and Bleeding in Patients with Atrial Fibrillation Undergoing Dialysis.
CONCLUSIONS: Our results suggest that warfarin use is not beneficial in reducing stroke risk but is associated with a higher bleeding risk in patients with AF undergoing dialysis. PMID: 24452752 [PubMed - as supplied by publisher]
Source: Circulation - January 22, 2014 Category: Cardiology Authors: Shah M, Avgil Tsadok M, Jackevicius CA, Essebag V, Eisenberg MJ, Rahme E, Humphries KH, Tu JV, Behlouli H, Guo H, Pilote L Tags: Circulation Source Type: research

Platelet Activation after Radiofrequency Ablation in Atrial Fibrillation: Is There Any Clinical Implication?
Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia in the general population and in patients undergoing cardiac surgery(1). AF is a self-perpetuating arrhythmia which is facilitated by structural and functional changes elicited by atrial high rate activity. Shortening of atrial effective refractory period is the earliest functional change that characterizes atrial remodeling(2). As prevalence of AF increases with advancing age, its social impact is becoming very relevant because of the associated high risk of cardiovascular events and increased morbidity and mortality. AF is complicated by str...
Source: Circulation - November 25, 2013 Category: Cardiology Authors: Violi F, Pignatelli P Tags: Circulation Source Type: research

The Impact of Partner Bereavement on Quality of Cardiovascular Disease Management.
CONCLUSIONS: Lower uptake of key cardiovascular care measures in the year before bereavement and reduced medication coverage after bereavement may contribute to increased cardiovascular risk. Clinicians need to ensure that quality of cardiovascular care is maintained in the pre and post bereavement period. PMID: 24255060 [PubMed - as supplied by publisher]
Source: Circulation - November 19, 2013 Category: Cardiology Authors: Shah SM, Carey IM, Harris T, Dewilde S, Victor CR, Cook DG Tags: Circulation Source Type: research

Effects of Visit-to-Visit Variability in Systolic Blood Pressure on Macrovascular and Microvascular Complications in Patient with Type 2 Diabetes: The ADVANCE Trial.
CONCLUSIONS: Visit-to-visit variability in SBP and maximum SBP were independent risk factors for macrovascular and microvascular complications in type 2 diabetes. CLINICAL TRIAL REGISTRATION INFORMATION: http://www.clinicaltrials.gov. Unique Identifier: NCT00145925. PMID: 23926207 [PubMed - as supplied by publisher]
Source: Circulation - August 7, 2013 Category: Cardiology Authors: Hata J, Arima H, Rothwell PM, Woodward M, Zoungas S, Anderson C, Patel A, Neal B, Glasziou P, Hamet P, Mancia G, Poulter N, Williams B, Macmahon S, Chalmers J, on behalf of the ADVANCE Collaborative Group Tags: Circulation Source Type: research

Rosiglitazone and Outcomes for Patients with Diabetes and Coronary Artery Disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial.
CONCLUSIONS: Among patients with type 2 diabetes and CAD in the BARI 2D trial, neither on-treatment nor propensity matched analysis supported an association of rosiglitazone treatment with an increase in major ischemic cardiovascular events. CLINICAL TRIAL REGISTRATION INFORMATION: http://www.clinicaltrials.gov. Identifier: NCT00006305. PMID: 23857320 [PubMed - as supplied by publisher]
Source: Circulation - July 15, 2013 Category: Cardiology Authors: Bach RG, Brooks MM, Lombardero M, Genuth S, Donner TW, Garber AJ, Kennedy L, Monrad ES, Pop-Busui R, Kelsey SF, Frye RL, for the BARI 2D Investigators Tags: Circulation Source Type: research

Impact of Aortic Valve Replacement on Outcome of Symptomatic Patients with Severe Aortic Stenosis with Low Gradient and Preserved Left Ventricular Ejection Fraction.
CONCLUSIONS: AVR is associated with better survival than medical therapy in patients with symptomatic low gradient severe AS and preserved LVEF. PMID: 23812184 [PubMed - as supplied by publisher]
Source: Circulation - June 27, 2013 Category: Cardiology Authors: Ozkan A, Hachamovitch R, Kapadia SR, Tuzcu EM, Marwick TH Tags: Circulation Source Type: research

Elevated blood pressure in pregnancy and subsequent chronic disease risk.
CONCLUSIONS: Elevated blood pressure during pregnancy, regardless of type and even without known risk factors, signals high risk of later cardiovascular disease, chronic kidney disease, and diabetes mellitus. Clinical monitoring, risk factor evaluation, and early intervention could benefit women with hypertension in pregnancy. PMID: 23401113 [PubMed - in process]
Source: Circulation - February 12, 2013 Category: Cardiology Authors: Männistö T, Mendola P, Vääräsmäki M, Järvelin MR, Hartikainen AL, Pouta A, Suvanto E Tags: Circulation Source Type: research

Percutaneous Left Atrial Appendage Closure for Stroke Prophylaxis in Patients with Atrial Fibrillation: 2.3 Year Follow-Up of the PROTECT AF Trial.
CONCLUSIONS: The "local" strategy of LAA closure is noninferior to "systemic" anticoagulation with Warfarin. PROTECT AF has, for the first time, implicated the LAA in the pathogenesis of stroke in AF. CLINICAL TRIAL REGISTRATION INFORMATION: Clinicaltrials.gov; Unique Identifier: NCT00129545. PMID: 23325525 [PubMed - as supplied by publisher]
Source: Circulation - January 16, 2013 Category: Cardiology Authors: Reddy VY, Doshi SK, Siever H, Buchbinder M, Neuzil P, Huber K, Halperin JL, Holmes D Tags: Circulation Source Type: research