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Atherothrombotic Risk Stratification and the Efficacy and Safety of Vorapaxar in Patients with Stable Ischemic Heart Disease and Prior Myocardial Infarction.
CONCLUSIONS: -Stratification of baseline atherothrombotic risk can assist with therapeutic decision-making regarding vorapaxar use for secondary prevention after MI. Clinical Trial Registration-http://www.clinicaltrials.gov; NCT00526474. PMID: 27440003 [PubMed - as supplied by publisher]
Source: Circulation - July 19, 2016 Category: Cardiology Authors: Bohula EA, Bonaca MP, Braunwald E, Aylward PE, Corbalan R, De Ferrari GM, He P, Lewis BS, Merlini PA, Murphy SA, Sabatine MS, Scirica BM, Morrow DA Tags: Circulation Source Type: research

Drugs That May Cause or Exacerbate Heart Failure: A Scientific Statement From the American Heart Association.
rgery and Anesthesia; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research Abstract Heart failure is a common, costly, and debilitating syndrome that is associated with a highly complex drug regimen, a large number of comorbidities, and a large and often disparate number of healthcare providers. All of these factors conspire to increase the risk of heart failure exacerbation by direct myocardial toxicity, drug-drug interactions, or both. This scientific statement is designed to serve as a comprehensive and accessible source of drugs that may cause or exacerbate heart f...
Source: Circulation - July 10, 2016 Category: Cardiology Authors: Page RL, O'Bryant CL, Cheng D, Dow TJ, Ky B, Stein CM, Spencer AP, Trupp RJ, Lindenfeld J, American Heart Association Clinical Pharmacology and Heart Failure and Transplantation Committees of the Council on Clinical Cardiology; Council on Cardiovascular S Tags: Circulation Source Type: research

Prediction of First Cardiovascular Disease Event in Type 1 Diabetes: The Steno T1 Risk Engine.
CONCLUSIONS: -This high performing CVD risk model allows the implementation of decision rules in a clinical setting. PMID: 26888765 [PubMed - as supplied by publisher]
Source: Circulation - February 17, 2016 Category: Cardiology Authors: Vistisen D, Andersen GS, Hansen CS, Hulman A, Henriksen JE, Beck-Nielsen H, Jørgensen ME Tags: Circulation Source Type: research

Epidemiology and Mechanisms of Uremia-Related Cardiovascular Disease.
Abstract Patients with chronic kidney disease and end-stage renal disease are at 5- to 10-fold higher risk for developing cardiovascular disease (CVD) than age-matched controls. Clinically, CVD in this population manifests as coronary artery disease, arrhythmias, stroke, or congestive heart failure. Beyond the traditional risk factors (eg, diabetes mellitus and hypertension), uremia-specific factors that arise from accumulating toxins also contribute to the pathogenesis of CVD. In this review, we summarize the literature on the epidemiology of both traditional and uremia-related CVD and focus on postulated mechani...
Source: Circulation - February 2, 2016 Category: Cardiology Authors: Tonelli M, Karumanchi SA, Thadhani R Tags: Circulation Source Type: research

SPS3 Evidence Supports Intensive Blood Pressure Control.
Abstract Interest in identifying the most appropriate targets for systolic blood pressure (SBP) lowering to reduce cardiovascular events in persons with hypertension has been piqued by the widely publicized results of the Systolic Blood Pressure Intervention Trial (SPRINT)(1,2). SPRINT found overwhelming benefit (25% reduction in the primary composite outcome of myocardial infarction (MI), acute coronary syndrome not resulting in MI, stroke, acute decompensated heart failure, or death from cardiovascular causes) and 27% reduction in all-cause mortality among participants randomized to a SBP target of < 120 mm H...
Source: Circulation - January 13, 2016 Category: Cardiology Authors: Oparil S Tags: Circulation Source Type: research

Risks of Death and Stroke in Patients Undergoing Hemodialysis With New-Onset Atrial Fibrillation: A Competing-Risk Analysis of a Nationwide Cohort.
CONCLUSIONS: -The risk of stroke was only modestly higher in patients undergoing hemodialysis with new-onset AF than in those without AF, and it became insignificant when accounting for the competing risk of in-hospital death. PMID: 26680239 [PubMed - as supplied by publisher]
Source: Circulation - December 17, 2015 Category: Cardiology Authors: Shih CJ, Ou SM, Chao PW, Kuo SC, Lee YJ, Yang CY, Tarng DC, Lin CC, Huang PH, Li SY, Chen YT Tags: Circulation Source Type: research

Response to Letter Regarding Article, "Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials.".
PMID: 26621661 [PubMed - in process]
Source: Circulation - December 1, 2015 Category: Cardiology Authors: Abdul-Rahim AH, Perez AC, Fulton RL, Jhund PS, Latini R, Tognoni G, Wikstrand J, Kjekshus J, Lip GY, Maggioni AP, Tavazzi L, Lees KR, McMurray JJ Tags: Circulation Source Type: research

Letter by Lin et al Regarding Article, "Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials.".
PMID: 26621660 [PubMed - in process]
Source: Circulation - December 1, 2015 Category: Cardiology Authors: Lin GM, Hung Y, Li YH Tags: Circulation Source Type: research

Stroke in Adults With Congenital Heart Disease: Incidence, Cumulative Risk and Predictors.
CONCLUSIONS: -Among ACHD-patients, one in eleven men and one in fifteen women suffered a stroke between age 18 and 64. Stroke-incidence was considerably higher than in the general population, especially at younger age. The most important predictors of ischemic stroke were heart failure, diabetes and recent myocardial infarction. Further research is required to see if advances in the management of ACHD may reduce this substantial stroke rate. PMID: 26597113 [PubMed - as supplied by publisher]
Source: Circulation - November 23, 2015 Category: Cardiology Authors: Lanz J, Brophy JM, Therrien J, Kaouache M, Guo L, Marelli AJ Tags: Circulation Source Type: research

The Study of Cardiovascular Health Outcomes in the Era of Claims Data: The Cardiovascular Health Study.
CONCLUSIONS: -The use of diagnostic codes from claims data as clinical events, especially when restricted to primary diagnoses, leads to an underestimation of event rates. Additionally, claims-based events data represent a composite endpoint that includes the outcome of interest and selected (misclassified) non-event hospitalizations. PMID: 26538580 [PubMed - as supplied by publisher]
Source: Circulation - November 4, 2015 Category: Cardiology Authors: Psaty BM, Delaney JA, Arnold AM, Curtis LH, Fitzpatrick AL, Heckbert SR, McKnight B, Ives D, Gottdiener JS, Kuller LH, Longstreth WT Tags: Circulation Source Type: research

How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People.
CONCLUSIONS: -The majority of initial presentations of CVD are neither MI nor ischemic stroke, yet most primary prevention studies focus on these presentations. Sex has differing associations with different CVDs, with implications for risk prediction and management strategies. Clinical Trial Registration Information-www.clinicaltrials.gov. Identifier: NCT01164371. PMID: 26330414 [PubMed - as supplied by publisher]
Source: Circulation - September 1, 2015 Category: Cardiology Authors: George J, Rapsomaniki E, Pujades-Rodriguez M, Shah AD, Denaxas S, Herrett E, Smeeth L, Timmis A, Hemingway H Tags: Circulation Source Type: research

Relation of Smoking with Total Mortality and Cardiovascular Events Among Patients with Diabetes: A Meta-Analysis and Systematic Review.
CONCLUSIONS: -Active smoking is associated with significantly increased risks of total mortality and cardiovascular events among diabetic patients, while smoking cessation was associated with reduced risks compared to current smoking. The findings provide strong evidence for the recommendation of quitting smoking among diabetic patients. PMID: 26311724 [PubMed - as supplied by publisher]
Source: Circulation - August 26, 2015 Category: Cardiology Authors: Pan A, Wang Y, Talaei M, Hu FB Tags: Circulation Source Type: research

Impact of Diabetes on Hospitalization for Heart Failure, Cardiovascular Events, and Death: Outcomes at 4 Years from the REACH Registry.
CONCLUSIONS: -Diabetes increases substantially the risk of death, ischemic events and heart failure. Patients with both diabetes and heart failure are at particularly elevated risk of cardiovascular death, highlighting the need for additional therapies in this high-risk population. PMID: 26152709 [PubMed - as supplied by publisher]
Source: Circulation - July 7, 2015 Category: Cardiology Authors: Cavender MA, Steg PG, Smith SC, Eagle K, Ohman EM, Goto S, Kuder J, Im K, Wilson PW, Bhatt DL Tags: Circulation Source Type: research

Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death.
CONCLUSIONS: -The acceptance of new measures of hyperglycemia is partly dependent on establishing their association with long-term outcomes. We found that fructosamine and glycated albumin were associated with vascular outcomes and mortality and that these associations were similar to those observed for HbA1c. PMID: 26022911 [PubMed - as supplied by publisher]
Source: Circulation - May 28, 2015 Category: Cardiology Authors: Selvin E, Rawlings AM, Lutsey P, Maruthur N, Pankow JS, Steffes M, Coresh J Tags: Circulation Source Type: research

Does Myocardial Infarction Beget Atrial Fibrillation and Atrial Fibrillation Beget Myocardial Infarction?
Abstract Atrial fibrillation (AF) affects millions of people worldwide.(1) It is already known several decades that AF is not a benign condition, and it's associated with a 5-fold increased risk of stroke, 3-fold increased risk of heart failure, and doubling of risk of dementia and death.(2-4) Myocardial infarction, and coronary heart disease, are traditional risk factors of AF,(5) however, whether myocardial infarction is a consequence of AF, has not been studied in great detail yet. The focus of current treatment for AF is pointed towards prevention of stroke. This is of utmost importance; however the other card...
Source: Circulation - April 27, 2015 Category: Cardiology Authors: Vermond RA, Van Gelder IC, Crijns HJ, Rienstra M Tags: Circulation Source Type: research

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