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Source: Molecular Neurobiology
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Total 171 results found since Jan 2013.

Lipoprotein (a) as a Predictor of Early Stroke Recurrence in Acute Ischemic Stroke
This study aims to determine lipoprotein (a) [Lp(a)] levels in serum and to investigate their associations with stroke recurrence events in a 3-month follow-up study in patients with acute ischemic stroke (AIS). Serum Lp(a) levels were determined in 203 ischemic stroke patients and 120 normal controls at admission. The severity and clinical outcome of ischemic stroke patients were evaluated by the National Institutes of Health Stroke Scale (NIHSS). We followed the participants for a median of 3  months using a standard questionnaire to determine the stroke recurrence events. The correlation analysis and multiple linear re...
Source: Molecular Neurobiology - December 20, 2016 Category: Neurology Source Type: research

Serum CXCL12 Levels as a Novel Predictor of Future Stroke Recurrence in Patients with Acute Ischemic Stroke
Abstract Previous studies had shown that CXC chemokine ligand-12 (CXCL12) plays a significant role in animal models of ischemic stroke, but its role in human stroke is unclear. The aim of this study was to test the relationship between elevated serum circulating CXCL12 levels and the 1-year stroke recurrence in Chinese patients with acute ischemic stroke (AIS). All consecutive patients with first-ever acute ischemic stroke from January 2011 to September 2013 were recruited to participate in the study. Serum levels of CXCL12 and National Institute of Health Stroke Scale (NIHSS) were measured at the time of admissio...
Source: Molecular Neurobiology - April 2, 2015 Category: Neurology Source Type: research

Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
AbstractFerroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid peroxidation. Animal experiments have shown the important roles of ferroptosis in ischemic stroke, but the evidence in human stroke is insufficient. This prospective study evaluated the associations between plasma ferroptosis biomarkers at hyperacute stage and long-term outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT). The plasma samples were collected immediately before and after EVT (T1 and T2) and at 24  h (T3) for the 126 s...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research

Chromosome 4q25 Variants and Age at Onset of Ischemic Stroke
Abstract Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese population. Genotyping of rs10033464 and rs2200733 was performed by improved multiple ligase detection reaction. One-way ANOVA was used to compare the mean age of ischemic stroke onset for each variant. Combined effects of these two variants on age at ischemic stroke onset were then estimated. Kaplan...
Source: Molecular Neurobiology - May 11, 2016 Category: Neurology Source Type: research

Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation
In this study, we conducted a pooled analysis of the data from 199 patients with acute ischemic stroke in the first trial and 390 in the second to reanalyze the efficacy and safety of Rd. Moreover, animal stroke models were carried out to explore the possible molecular mechanisms underlying Rd neuroprotection. The pooled analysis showed that compared with placebo group, Rd could improve patients’ disability as assessed by modified Rankin Scale (mRS) score on day 90 post-stroke and reduce neurologic deficits on day 15 or day 90 post-stroke as assessed by NIH Stroke Scale (NIHSS) and Barthel Index (BI) scores. For neuropro...
Source: Molecular Neurobiology - June 17, 2015 Category: Neurology Source Type: research

Exogenous Neural Stem Cells Transplantation as a Potential Therapy for Photothrombotic Ischemia Stroke in Kunming Mice Model
In this study, we explore the transplantation of exogenous neural stem cells (NSCs) as the potential therapy for the photothrombotic ischemia stroke in a Kunming mice model. After stroke, mice receiving NSC transplantation demonstrated a better recovery of brain function during the neurobehavioral tests. Histology analysis of the brain samples from NSC transplanted mice demonstrated a reduction of brain damage caused by stroke. Moreover, immunofluorescence assay for biomarkers in brain sections confirmed that transplanted NSCs indeed differentiated to neurons and astrocytes, consistent with the improved brain function afte...
Source: Molecular Neurobiology - January 28, 2016 Category: Neurology Source Type: research

Remote Ischemic Postconditioning vs. Physical Exercise After Stroke: an Alternative Rehabilitation Strategy?
AbstractThere remain debates on neuroprotection and rehabilitation techniques for acute ischemic stroke patients. Therapeutic physical exercise following stroke has shown promise but is challenging to apply clinically. Ischemic conditioning, which has several clinical advantages, is a potential neuroprotective method for stroke rehabilitation that is less understood. In the present study, the rehabilitative properties and mechanisms of physical exercise and remote ischemic postconditioning (RIPostC) after stroke were compared and determined. A total of 248 adult male Sprague-Dawley rats were divided into five groups: (1) s...
Source: Molecular Neurobiology - July 1, 2021 Category: Neurology Source Type: research

Post-stroke Impairment of the Blood –Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway
AbstractPost-stroke edema and upregulation of aquaporin 4 (AQP4) water transport channels play a significant role in the progression of stroke pathology and deteriorating stroke outcomes. Prior studies from our lab have demonstrated the safety and efficacy of intra-arterial (IA) 1  × 105 mesenchymal stem cells (MSCs) administration post-stroke towards functional restoration and neuroprotection. Protein kinases have been reported to be involved in the signaling cascade of edema, with evidence supporting both its upregulation and downregulation at 24  h post-stroke. Among different protein kinase C (PKC) isoforms, the ...
Source: Molecular Neurobiology - February 21, 2022 Category: Neurology Source Type: research

Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke
Abstract Previous studies assessing the association between serum uric acid levels and neurological outcome after acute ischemic stroke reported conflicting results. A systematic review and meta-analysis were conducted to assess the impact of serum uric acid levels on outcome after acute ischemic stroke. Pubmed, Embase, Web of Science, and Google scholar were searched through September 26, 2014 to identify eligible published or unpublished studies on the association between serum uric acid levels and outcome after acute ischemic stroke. Hazard ratio (HR) for poor outcome or mean differences of serum uric acid leve...
Source: Molecular Neurobiology - March 6, 2015 Category: Neurology Source Type: research

Extracellular Matrix Modulation Is Driven by Experience-Dependent Plasticity During Stroke Recovery
This study provides molecular targets for novel therapi es that could support rehabilitation of stroke patients.
Source: Molecular Neurobiology - March 12, 2017 Category: Neurology Source Type: research

Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Impairment in Stroke Patients: A Meta-Analysis
Abstract Emerging evidence has shown that repetitive transcranial magnetic stimulation (rTMS) may significantly improve cognitive impairment in stroke patients, but individually published studies show inconclusive results. This meta-analysis aimed to derive a more precise estimation of the effects of rTMS on cognitive impairment in stroke patients based on studies published in peer-reviewed journals. A literature search of MEDLINE, Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, and three Chinese databases were conducted on articles published before April 30, 2014. Cru...
Source: Molecular Neurobiology - September 18, 2014 Category: Neurology Source Type: research

PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population
Abstract A recent genome-wide association study (GWAS) identified a nonsynonymous SNP (1425G/A) in PRKCH which was associated with increased risk of ischemic stroke. The purpose of this study was to examine whether this functional polymorphism is associated with stroke onset and prognosis in a Chinese population. We genotyped PRKCH 1425G/A using Improved Multiple Ligase Detection Reaction in 919 patients with ischemic stroke. Analyses of genotype association with onset and prognosis outcomes were assessed by the Kaplan-Meier method, the log-rank test, and the Cox proportional hazards models. PRKCH 1425G/A was not ...
Source: Molecular Neurobiology - November 5, 2014 Category: Neurology Source Type: research

Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk
Abstract Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the literature search in PubMed and Embase through October 2014 for all the potentially relevant studies. The odds ratios (ORs), together with the corresponding 95 % confidence intervals (95 % CIs) were calculated to evaluate the strength of association. The search yielded eight studies (13 reports ...
Source: Molecular Neurobiology - July 11, 2015 Category: Neurology Source Type: research