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Source: International Journal of Cardiology
Therapy: Statin Therapy
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Total 18 results found since Jan 2013.
Searching for the ideal LDL cholesterol estimating formula
For long, low-density lipoprotein cholesterol (LDL-C) has been considered one of the major therapeutic targets for primary and secondary prevention in cardiovascular (CV) disease. Since more than two decades ago, pivotal trials have demonstrated that LDL-C lowering with statins translates into a log proportional reduction in a vast array of CV events (myocardial infarction, stroke, need for coronary or arterial revascularization), as well as mortality [1]. More recently, similar benefits have been observed with other LDL-C lowering therapies, such as ezetimibe [2] and proprotein covertase subtilisin kexin type 9 (PCSK-9) inhibitors [3].
Source: International Journal of Cardiology - March 9, 2021 Category: Cardiology Authors: Remo Holanda de Mendonca Furtado Tags: Editorial Source Type: research
Use of statins and adverse outcomes in patients with atrial fibrillation: An analysis from the EURObservational Research Programme Atrial Fibrillation (EORP-AF) general registry pilot phase
Despite oral anticoagulation being highly effective in reducing stroke and thromboembolism, patients with atrial fibrillation (AF) still have a significant residual excess in mortality risk. Additional management strategies are needed to reduce the mortality risk seen in AF patients.
Source: International Journal of Cardiology - August 25, 2017 Category: Cardiology Authors: Marco Proietti, C écile Laroche, Ole Nyvad, Maciej Haberka, Vassilios P. Vassilikos, Aldo P. Maggioni, Giuseppe Boriani, Gregory Y.H. Lip, EORP-AF Pilot Investigators Source Type: research
Atorvastatin inhibits miR-143 expression: A protective mechanism against oxidative stress in cardiomyocytes
Statins are unequivocally the most widely prescribed drug for the primary and secondary prevention of coronary artery disease worldwide [1]. Atorvastatin is the most commonly prescribed statin drug due to its lower therapeutic dose comared to others. The well-tolerated and high benefit–risk ration of atorvastain has been demonstrated in clinical trials [2]. Atorvastatin reduce the risk of myocardial infarction, stroke, and death, primarily inhibiting reactive oxygen species (ROS) [3].
Source: International Journal of Cardiology - March 1, 2016 Category: Cardiology Authors: Shanshan Tian, Wei Zhao, Di Yang, Yang Yu, Jiaqi Zou, Zhiyan Liu, Zhimin Du Tags: Correspondence Source Type: research
Efficacy of ezetimibe: A real effect?
We do not agree with the methods and the conclusions of the systematic review of Savarese et al. [1]. Their meta-analysis of seven randomized controlled trials tests the safety and the efficacy of ezetimibe (E), added to a statin, in comparison indifferently versus placebo or active treatment and shows a favorable effect of E on risks of major non-fatal endpoints (myocardial infarction RR: 0.865, 95% CI: 0.801–0.934; stroke RR: 0.840, 95% CI: 0.744–0.949), with a neutral effect on mortality outcomes (all-cause death RR: 1.003, 95% CI: 0.954–1.055; CV death RR: 0.958, 95% CI: 0.879–1.044) and new cancer risk (RR: 1....
Source: International Journal of Cardiology - February 24, 2016 Category: Cardiology Authors: Alberto Donzelli, Alessandro Battaggia Tags: Correspondence Source Type: research
Healthy lifestyle factors and incident heart disease and mortality in candidates for primary prevention with statin therapy
There are limited data on the use of healthy lifestyles among adults who are candidates for primary prevention of atherosclerotic cardiovascular disease (ASCVD) with statin therapy due to a 10-year predicted risk ≥7.5%. We determined the prevalence of healthy lifestyle factors and their association with incident ASCVD and all-cause mortality in the Reason for Geographic and Racial Differences in Stroke study participants (n=5709).
Source: International Journal of Cardiology - January 6, 2016 Category: Cardiology Authors: John N. Booth III, Lisandro D. Colantonio, George Howard, Monika Safford, Maciej Banach, Kristi Reynolds, Mary Cushman, Paul Muntner Source Type: research
High dose atorvastatin therapy yields a better carotid atherosclerosis improvement in Chinese patients
Statins is one of key components in the cocktail of medications for the treatment of patients with atherosclerosis and have proved to reduce vascular events significantly in primary and secondary prevention of coronary heart disease (CHD) in the past decades [1–3]. As the most widely used statins, the effectiveness of atorvastatin in lowering LDL-C has been demonstrated in several trials [4,5]. Plasma LDL-C levels and carotid intima-media thickness (IMT) have been proved associated with incidence of stroke [6].
Source: International Journal of Cardiology - March 11, 2015 Category: Cardiology Authors: Yafeng Li, Shoucui Gao, Yingfeng An, Enqi Liu, Sihai Zhao Source Type: research
Cost-Effectiveness Analysis of Alternative Screening and Treatment Strategies for Heterozygous Familial Hypercholesterolemia in the United States
This study evaluates the cost-effectiveness of genetic screening and lipid-based screening with statin adherence measures compared to lipid-based screening alone in the US.
Source: International Journal of Cardiology - December 23, 2014 Category: Cardiology Authors: Christina X. Chen, Joel W. Hay Source Type: research
Statin treatment is associated with improved prognosis in patients with AF-related stroke
The most recent ACC/AHA guidelines recommend high-intensity statin therapy in ischemic stroke patients of presumably atherosclerotic origin. On the contrary, there is no specific recommendation for the use of statin in patients with non-atherosclerotic stroke, e.g. strokes related to atrial fibrillation (AF). We investigated whether statin treatment in patients with AF-related stroke is associated with improved survival and reduced risk for stroke recurrence and future cardiovascular events.
Source: International Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: G. Ntaios, V. Papavasileiou, K. Makaritsis, H. Milionis, E. Manios, P. Michel, G.Y.H. Lip, K. Vemmos Source Type: research
Use of drug treatment for secondary prevention of cardiovascular disease in urban and rural communities of China: China Kadoorie Biobank Study of 0.5million people
Conclusions: Despite recent improvements in hospital care in China, only one in three individuals with prior CVD was routinely treated with any proven secondary preventive drugs. The treatment rates were correlated with the existence of other risk factors, in particular evidence of hypertension.
Source: International Journal of Cardiology - January 23, 2014 Category: Cardiology Authors: Yiping Chen, Liming Li, Qiuli Zhang, Robert Clarke, Junshi Chen, Yu Guo, Zheng Bian, Xianhai Pan, Richard Peto, Ran Tao, Kunxiang Shi, Rory Collins, Liangcai Ma, Huarong Sun, Zhengming Chen, on behalf of China Kadoorie Biobank Study Tags: Original Articles Source Type: research
Long-term cardiovascular outcomes in patients with atrial fibrillation and atherothrombosis in the REACH Registry
Abstract: Background: Patients with atrial fibrillation (AF) are at increased risk of thromboembolic events. The long-term prognostic implications of AF in patients with atherothrombosis are unknown.Methods: We compared 4-year CV outcomes in patients with and without a history of AF recorded at their baseline visit in the REACH Registry, an international, prospective cohort of patients with established atherosclerotic arterial disease (CAD, CVD, PAD) or at least 3 risk factors (RFO).Results: AF status and 4year follow-up data were available on 44,518 patients. The prevalence of AF at baseline was 10.3% (n=4582). Overall, p...
Source: International Journal of Cardiology - December 9, 2013 Category: Cardiology Authors: Christian T. Ruff, Deepak L. Bhatt, Ph. Gabriel Steg, Bernard J. Gersh, Mark J. Alberts, Elaine B. Hoffman, E. Magnus Ohman, Kim A. Eagle, Gregory Y.H. Lip, Shinya Goto, On Behalf of the REACH Registry Investigators Tags: Original Articles Source Type: research
The beneficial effects of statins in patients undergoing hemodialysis
Abstract: Background: The beneficial effects of statins in patients undergoing hemodialysis are controversial. Our study aimed to investigate the use of statins and the subsequent risk of cardiovascular morbidity and mortality in patients undergoing hemodialysis.Methods: We conducted a cohort study using data from the Taiwan National Health Insurance Research Database. Cox regressions were performed to determine the hazard ratio (HR) of cardiovascular morbidity and mortality in the HD patients taking statins (statin cohort) compared with a propensity-matched comparison cohort.Results: The statin cohort included a total of ...
Source: International Journal of Cardiology - August 7, 2013 Category: Cardiology Authors: Chin-Chou Huang, Wan-Leong Chan, Yu-Chun Chen, Tzeng-Ji Chen, Chia-Min Chung, Po-Hsun Huang, Shing-Jong Lin, Jaw-Wen Chen, Hsin-Bang Leu Tags: Original Articles Source Type: research
Efficacy of different statins for primary prevention of atrial fibrillation in male and female patients: A nationwide population-based cohort study
Atrial fibrillation (AF) is a common arrhythmia and is associated with increased cardiovascular morbidity and mortality . Meta-analysis of randomized controlled trials has showed that statin provides a protective effect against AF . However, different statins may have different levels of efficacy in AF prevention . Statin therapy exhibited different effects between genders in reducing mortality and stroke , and the data on a gender effect of statin in primary prevention of AF is limited. The purpose of this study was to determine the efficacy of different statins for primary prevention of AF in male and female patients.
Source: International Journal of Cardiology - May 29, 2013 Category: Cardiology Authors: Chen-Ying Hung, Yu-Cheng Hsieh, Kuo-Yang Wang, Jin-Long Huang, El-Wui Loh, Ching-Heng Lin, Tsu-Juey Wu Tags: Letters to the Editor Source Type: research
Treatment with statins improves long-term survival in individuals with carotid artery stenosis
Statin therapy has an established role in the treatment of arteriosclerotic disease and in secondary stroke prevention. Up to 20% of relative risk reduction in major vascular events per 1mmol/L decrease in LDL cholesterol is reported . Atherosclerotic carotid stenosis is an important risk factor for stroke and the inflammatory process of arteriosclerosis is shown to be most pronounced in the early stages. We have earlier shown that statin treatment may prevent and even reverse the progression of stenosis in the internal carotid artery (ICA) over time . We have now 10years later investigated survival and causes of death dur...
Source: International Journal of Cardiology - March 1, 2013 Category: Cardiology Authors: Sara Maria Wörlund, Martin W. Kurz, Øivind Hegland, Kolbjørn Brønnick, Peter Scott Munk, Jan Petter Larsen Tags: Letters to the Editor Source Type: research
Left atrial size and function as predictors of new-onset of atrial fibrillation in patients with asymptomatic aortic stenosis: The simvastatin and ezetimibe in aortic stenosis study
Abstract: Background: Left atrial (LA) size and function change with chronically increased left ventricular (LV) filling pressures. It remains unclear whether these variations in LA parameters can predict new-onset atrial fibrillation (AF) in asymptomatic patients with aortic stenosis (AS).Methods: Data were obtained in asymptomatic patients with mild-to-moderate AS (2.5≤ transaortic Doppler velocity ≤4.0m/s), preserved LV ejection fraction (EF), no previous AF, and were enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study. Peak-aortic velocity, LAmax volume & LAmin volume were measured by echocardiograph...
Source: International Journal of Cardiology - February 18, 2013 Category: Cardiology Authors: Casper N. Bang, Morten Dalsgaard, Anders M. Greve, Lars Køber, Christa Gohlke-Baerwolf, Simon Ray, Anne B. Rossebø, Kenneth Egstrup, Kristian Wachtell Tags: Original Articles Source Type: research
