• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

REACHing conclusions on the external applicability of the THEMIS into clinical practice
The THEMIS Study (Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients) was a phase 3 randomized, double-blinded, placebo-controlled trial from 2014 to 2016. Patients with angiographically proven coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM), but no prior history of myocardial infarction (MI) or stroke, were randomized 1:1 to either ticagrelor or placebo in addition to low-dose aspirin for a median follow-up of 39.9  months. The randomized population (n = 19,220) had a median age of 66years, 31.4% were women, and there was a high prevalence of concomitant hypertension, dyslipidemi...
Source: International Journal of Cardiology - December 31, 2022 Category: Cardiology Authors: Rahul Gupta, Adriana C. Mares Tags: Editorial Source Type: research

Diastolic dysfunction in women with ischemia and non-obstructive coronary arteries (INOCA) – Could non-invasive imaging reveal the missing piece of puzzle?
A large proportion of patients with chronic coronary syndromes will not have obstructive coronary artery disease (CAD) on invasive coronary angiography, more often women than men [1]. Ischemia with non-obstructive coronary arteries (INOCA), once considered a benign condition, is now recognized to be associated with increased risk of adverse events, including heart failure (HF), myocardial infarction, stroke and cardiovascular death as well as increased number of hospitalizations [2 –5]. Among INOCA patients, those with evidence of both coronary microvascular and diastolic dysfunction seem to bear the highest risk of adve...
Source: International Journal of Cardiology - April 16, 2021 Category: Cardiology Authors: Anca Florian Tags: Editorial Source Type: research

Determinants of Stroke Following Percutaneous Coronary Intervention in Acute Myocardial Infarction (from ORPKI Polish National Registry)
Both hemorrhagic and ischemic cerebrovascular events are rare but serious complications after acute myocardial infarction (MI) and coronary angiography / percutaneous coronary intervention (PCI). The most threatening one is intracranial hemorrhage related to antiplatelet and antithrombotic treatment of acute MI. In up to 10% of patients with acute MI ischemic stroke can result from embolisation of intraventricular or intraatrial thrombi [1]. It may occur within the first 2weeks, but also as early as in the first 24h.
Source: International Journal of Cardiology - August 10, 2016 Category: Cardiology Authors: Artur Dziewierz, Zbigniew Siudak, Tomasz Tokarek, Tomasz Rakowski, Dariusz Dudek Source Type: research

Clinical Significance of Plasma Galectin-3 in Patients with Coronary Artery Disease
Atherosclerosis is a major cause of stroke and cardiovascular diseases, including coronary artery disease (CAD) [1], and Inflammation is known to play a key role in atherosclerosis. Galectin-3 (Gal3), one of family members of soluble β-galactoside binding lectins, has pivotal role in atherogenesis through the enhancement of phagocytosis [2] and the induction of vascular smooth muscle cells proliferation [3]. Recently, Maiolino et al. reported that plasma Gal3 could predict cardiovascular death in high-risk patients referred for coronary angiography (CAG) [4].
Source: International Journal of Cardiology - August 10, 2015 Category: Cardiology Authors: Hiroaki Kusaka, Eiichiro Yamamoto, Yoshihiro Hirata, Koichiro Fujisue, Takanori Tokitsu, Koichi Sugamura, Kenji Sakamoto, Kenichi Tsujita, Koichi Kaikita, Seiji Hokimoto, Seigo Sugiyama, Hisao Ogawa Source Type: research

Recurrent coronary vasospasm-induced acute coronary syndrome complicated by cardiac arrest
We report a case of a 62-year-old male patient who was transferred to the emergency department after a successfully resuscitated cardiac arrest. He presented with persistent retrosternal chest pain. In the electrocardiogram ST-segment elevations and negative T waves in precardial leads were found (Fig. 1). The patient was current smoker, with a history of previous stroke and arterial hypertension. During emergency angiography, critical stenosis within the proximal left anterior descending coronary artery was found (Fig. 2A).
Source: International Journal of Cardiology - March 4, 2015 Category: Cardiology Authors: Michał Chyrchel, Artur Dziewierz, Dariusz Dudek Tags: Letter to the Editor Source Type: research

Acute Myocardial Infarction and Acute Stroke: Between a Rock and a Hard Place
A 53year-old woman developed severe chest pain, breathlessness and palpitations whilst being told some very devastating news. As the symptoms persisted for more than 15minutes, electrocardiography was undertaken in the community confirming an anterolateral STEMI. Following the electrocardiographic findings the patient was loaded orally in the community with aspirin 300mg and clopidogrel 600mg and was urgently transferred via the community activation primary PCI route to our institution for emergency coronary angiography.
Source: International Journal of Cardiology - October 22, 2014 Category: Cardiology Authors: Vassilios Vassiliou, Bushra Rana, Martin Goddard, Denise Braganza Tags: Letter to the editor Source Type: research

Submillisievert ECG-gated whole thoracic CT-angiography for evaluation of a complex congenital heart defect in a young woman
A 30year old Caucasian woman presented to the emergency department with recurrent occipital headache, amnesic aphasia and apraxia of the upper extremities being exaggerated during physical and emotional stress for one week. 40days ago the woman gave birth to her third child, an apparently healthy female. Cerebral magnetic resonance imaging (MRI) showed evidence of sub-acute ischemia at the left frontal insula, corresponding to an embolic occluded distal side branch of the mid-cerebral artery. The patient was immediately transferred to the stroke unit.
Source: International Journal of Cardiology - July 12, 2014 Category: Cardiology Authors: Michael Behnes, Holger Haubenreisser, Aydin Huseynov, Christian Boecker, Stefan Baumann, Felix Heggemann, Tobias Becher, Ursula Hoffmann, Elif Elmas, Theano Papavassiliu, Martin Borggrefe, Stefan Schoenberg, Thomas Henzler, Ibrahim Akin Tags: Letter to the Editor Source Type: research

Angiographic success and procedural complications in patients undergoing retrograde percutaneous coronary chronic total occlusion interventions: A weighted meta-analysis of 3482 patients from 26 studies
Conclusions: Retrograde CTO PCI is associated with high procedural success rate and acceptable risk for procedural complications.
Source: International Journal of Cardiology - April 25, 2014 Category: Cardiology Authors: Abdallah El Sabbagh, Vishal G. Patel, Omar M. Jeroudi, Tesfaldet T. Michael, Mohammed E. Alomar, Owen Mogabgab, Eric Fuh, Michele Roesle, Bavana V. Rangan, Shuaib Abdullah, Jeffrey L. Hastings, Jerrold Grodin, Dharam J. Kumbhani, Dimitrios Alexopoulos, Pa Tags: Reviews Source Type: research

CABG versus PCI in diabetic patients with multivessel disease after risk stratification by the SYNTAX score: A pooled analysis of the SYNTAX and FREEDOM trials
The 2010 European guidelines for myocardial revascularization indicate coronary artery bypass grafting (CABG) as a class I recommendation for patients with stable coronary multivessel disease (MVD), regardless of the angiographic burden reflected by the SYNTAX score . In contrast, percutaneous coronary intervention (PCI) is contraindicated (class III) in patients with MVD and intermediate to high (>22) SYNTAX score, while it is considered reasonable (class IIa) in patients with MVD and low (0–22) SYNTAX score. Recently, in the 2013 European guidelines on the management of patients with diabetes mellitus, PCI for MVD has ...
Source: International Journal of Cardiology - April 3, 2014 Category: Cardiology Authors: Davide Capodanno, Piera Capranzano, Corrado Tamburino Tags: Letters to the Editor Source Type: research

Simultaneous onset of myocardial infarction and ischemic stroke in a patient with atrial fibrillation: Multiple territory injury revealed on angiography and magnetic resonance
An 84-year-old man with a history of hypertension and paroxysmal atrial fibrillation (AF) who received no anticoagulant drugs experienced acute chest pain and transient loss of consciousness. He was transferred to our emergency room. His initial electrocardiogram showed sinus rhythm with ST-segment elevation in the I, aVL, and V1–V6 leads. His blood pressure was 158/92mmHg and his pulse was regular at 70beats per minute. A chest radiograph showed increased heart size and pulmonary vascular congestion. His troponin T level was elevated (more than 0.1ng/mL). He was diagnosed with ST-elevation myocardial infarction (MI) and...
Source: International Journal of Cardiology - February 4, 2014 Category: Cardiology Authors: Osamu Hashimoto, Kozo Sato, Yohei Numasawa, Joji Hosokawa, Masahiro Endo Tags: Online Letters to the Editor Source Type: research

Left atrial appendage closure with the Amplatzer™ Cardiac Plug: Impact of shape and device sizing on follow-up leaks
Conclusions: Although the shape and sizing of the device were not linked to any particular clinical outcome, we found an association between a lower degree of over-sizing and the presence of follow-up leaks.
Source: International Journal of Cardiology - September 30, 2013 Category: Cardiology Authors: Xavier Freixa, Apostolos Tzikas, Ayax Sobrino, Jason Chan, Arsène J. Basmadjian, Réda Ibrahim Tags: Original Articles Source Type: research

The Virtual histology In CaroTids Observational RegistrY (VICTORY) study: A European prospective registry to assess the feasibility and safety of intravascular ultrasound and virtual histology during carotid interventions
Abstract: Background: Carotid occlusive disease is the most common determinant of thromboembolic stroke. However, limited insights in vivo into the pathophysiology and pathology of carotid plaques are available. We designed a prospective multicenter registry to appraise the safety and feasibility of intravascular ultrasound (IVUS) and IVUS–virtual histology (IVUS–VH) imaging before and immediately after carotid stenting.Methods: Symptomatic and asymptomatic patients scheduled for carotid stenting were included. IVUS–VH pullbacks were performed before and after stenting. Angiographic, IVUS and IVUS–VH analyses were ...
Source: International Journal of Cardiology - March 1, 2013 Category: Cardiology Authors: Giuseppe Sangiorgi, Francesco Bedogni, Paolo Sganzerla, Giorgio Binetti, Luigi Inglese, Piotr Musialek, Giovanni Esposito, Alberto Cremonesi, Giorgio Biasi, Jacek Jakala, Alessandro Mauriello, Giuseppe Biondi-Zoccai Tags: Original Articles Source Type: research

A meta-analytic overview of thrombectomy during primary angioplasty
Conclusions: The present meta-analysis has demonstrated that, among patients with STEMI, manual thrombectomy significantly improved myocardial perfusion, with a trend in short-term mortality benefits, whereas mechanical thrombectomy, despite the benefits in myocardial perfusion, did not impact on short-term survival. However, the benefits in myocardial perfusion were significantly related to prevalence of coronary thrombus. In light of the observed higher risk of stroke, thrombectomy cannot be routinely recommended, but should be used in case of evident intracoronary thrombus. Mechanical thrombectomy devices may be conside...
Source: International Journal of Cardiology - January 27, 2012 Category: Cardiology Authors: Giuseppe De Luca, Eliano Pio Navarese, Harry Suryapranata Tags: Original Articles Source Type: research

Carotid plaque is associated with increased cardiac mortality in patients with coronary artery disease
Abstract: Background: It is still controversial whether carotid plaque is associated with cardiovascular events in patients with coronary artery disease (CAD). The aim of the present study is to evaluate the impact of carotid plaque on long term clinical outcomes especially in patients with CAD.Methods: The study population consisted of 1390 consecutive patients with angiographically proven CAD. All subjects underwent carotid scanning 1day before or after coronary angiogram and were followed up for major adverse cardiovascular events (MACE; death, myocardial infarction, stroke, revascularization, restenosis and hospitaliza...
Source: International Journal of Cardiology - December 22, 2011 Category: Cardiology Authors: Hyun Woong Park, Wan Ho Kim, Ki-Hong Kim, Dong Ju Yang, Ji Hye Kim, In Girl Song, Taek-Geun Kwon, Jang-Ho Bae Tags: Original Articles Source Type: research