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Source: International Journal of Cardiology
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Total 880 results found since Jan 2013.
Silent atrial fibrillation: A clinical conundrum
The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) reported that about 10% of the patients in a pool of 2850 selected subjects (older than 65years of age) with pacemakers had subclinical atrial fibrillation (AF). The study also reported that the risk of developing an ischemic stroke or systemic embolism was 2.5 fold higher for patients with subclinical AF, compared with patients without after a follow-up period of 2.5years . These findings remain relevant and important with about a million cardiac pacemakers being implanted eve...
Source: International Journal of Cardiology - May 9, 2013 Category: Cardiology Authors: Mohit K. Turagam Tags: Letters to the Editor Source Type: research
A general theory of acute and chronic heart failure
Abstract: Current concepts of heart failure propose multiple heterogeneous pathophysiological mechanisms. Recently a theoretical framework for understanding chronic heart failure was suggested. This paper develops this framework to include acute heart failure syndromes.We propose that all acute heart failure syndromes may be understood in terms of a relative fall in left ventricular stroke volume. The initial compensatory mechanism is frequently a tachycardia often resulting in a near normal cardiac output. In more severe forms a fall in cardiac output causes hypotension or cardiogenic shock. In chronic heart failure the s...
Source: International Journal of Cardiology - April 9, 2012 Category: Cardiology Authors: David H. MacIver, Mark J. Dayer, Andrew J.I. Harrison Tags: Reviews Source Type: research
Dairy intake and coronary heart disease or stroke—A population-based cohort study
This study aimed to investigate the relationship between total dairy intake and dairy subtypes (high-fat dairy, low-fat dairy, milk and milk products, cheese and fermented dairy) with incident coronary heart disease (CHD) and stroke.Methods: EPIC-NL is a prospective cohort study among 33,625 Dutch men and women. At baseline (1993–1997), dairy intake was measured with a validated food frequency questionnaire (FFQ). The incidence of both fatal and non-fatal CHD and stroke was obtained by linkage to the national registers.Results: During 13years follow-up, 1648 cases of CHD and 531 cases of stroke were documented. Total dai...
Source: International Journal of Cardiology - April 6, 2012 Category: Cardiology Authors: Geertje W. Dalmeijer, Ellen A. Struijk, Yvonne T. van der Schouw, Sabita S. Soedamah-Muthu, W.M. Monique Verschuren, Jolanda M.A. Boer, Johanna M. Geleijnse, Joline W.J. Beulens Tags: Original Articles Source Type: research
Pattern of atrial fibrillation and risk of outcomes: The Loire Valley Atrial Fibrillation Project
Abstract: Background: Risk of stroke and thromboembolism (TE) in patients with non-valvular atrial fibrillation (NVAF) is categorised in stroke risk stratification scores. The role of pattern of NVAF in risk prediction is unclear in contemporary ‘real world’ cohorts.Methods and results: Patients with NVAF in a four-hospital-institution between 2000 and 2010 were included. Stroke/TE event rates were calculated according to pattern of AF, i.e. paroxysmal, persistent and permanent. Risk factors were investigated by Cox regression.Among 7156 NVAF patients, 4176 (58.4%) patients with paroxysmal, 376 (5.3%) with persistent a...
Source: International Journal of Cardiology - July 16, 2012 Category: Cardiology Authors: Amitava Banerjee, Sophie Taillandier, Jonas Bjerring Olesen, Deirdre A. Lane, Benedicte Lallemand, Gregory Y.H. Lip, Laurent Fauchier Tags: Original Articles Source Type: research
Blood pressure. The forgotten factor in previous and recent studies regarding anticoagulation in atrial fibrillation
Atrial fibrillation is an independent risk factor for stroke and thromboembolic events . For several years the anticoagulation was principally limited to vitamine K antagonists (VKA). It was an effective drug with advantages but also disadvantages like variable response and the need for periodically INR monitoring. This has led the pharmaceutical industry to the development of newer oral anticoagulants at least as effective (or more effective) as VKAs, with lower (or similar, depending the dose) risk of bleeding and a convenient dosing regiment without the need for INR monitoring. Several studies published recently like RO...
Source: International Journal of Cardiology - July 29, 2013 Category: Cardiology Authors: M.S. Kallistratos, A.J. Manolis, G. Mancia Tags: Letters to the Editor Source Type: research
Outcomes in atrial fibrillation patients on combined warfarin & antiarrhythmic therapy
Conclusions: Allowing for differences in prescribing practice, AF/AFL patients treated with W+A are at higher risk of stroke and arterial embolism, and have higher healthcare use and costs, than patients receiving W+OAAD.
Source: International Journal of Cardiology - February 15, 2012 Category: Cardiology Authors: Annie Guérin, Jay Lin, Mehul Jhaveri, Eric Q. Wu, Andrew P. Yu, Martin Cloutier, Genevieve Gauthier, Joseph S. Alpert Tags: Original Articles Source Type: research
Benefits and risks of long-term duration of dual antiplatelet therapy after drug-eluting stenting: A meta-analysis of randomized trials
Conclusions: This meta-analysis provides no evidence of benefits with longer DAPT duration as compared with a shorter course of therapy. It also reports significant harms with respect to major bleeding and stroke associated with prolonged DAPT use.
Source: International Journal of Cardiology - April 15, 2013 Category: Cardiology Authors: Marco Valgimigli, Seung-Jung Park, Hyo-Soo Kim, Kyung Woo Park, Duk-Woo Park, Pierluigi Tricoci, Giuseppe Ferrante Tags: Original Articles Source Type: research
Effect of calcium or vitamin D supplementation on vascular outcomes: A meta-analysis of randomized controlled trials
Conclusions: Calcium supplementation might increase the risk of major cardiovascular events, myocardial infarction, and stroke compared to the risk with a placebo.
Source: International Journal of Cardiology - September 12, 2013 Category: Cardiology Authors: Pei-Juan Mao, Chi Zhang, Lan Tang, Yu-Qiong Xian, Yan-Song Li, Wei-Dong Wang, Xiu-Hua Zhu, Hua-Li Qiu, Jia He, Yu-Hao Zhou Tags: Reviews Source Type: research
Screening for atrial fibrillation in patients with obstructive sleep apnoea to reduce ischaemic strokes
Abstract: Obstructive sleep apnoea is an independent risk factor for stroke. A number of different mechanisms have been identified which link OSA and stroke including hypertension and oxidative stress. Atrial fibrillation (AF) is likely to play a role in the development of stroke in patients with OSA. Indeed, patients with OSA have a higher incidence of AF than the general population. Given the higher constellation of cardiovascular co-morbidities seen in patients with OSA, we believe that a strategy of actively screening for the presence of AF in patients with OSA and initiating oral anticoagulation therapy when appropria...
Source: International Journal of Cardiology - January 27, 2014 Category: Cardiology Authors: D. Wilson, A. Frontera, G. Thomas, E. Duncan Tags: Editorials Source Type: research
Reduction of albumin urinary excretion is associated with reduced cardiovascular events in hypertensive and/or diabetic patients. A meta-regression analysis of 32 randomized trials
Conclusions: Reduction in UAE is associated with reduced risk of MI and stroke in diabetic and/or hypertensive patients. These findings suggest that UAE changes may represent a valuable intermediate end-point for CV risk evaluation in clinical practice.
Source: International Journal of Cardiology - February 5, 2014 Category: Cardiology Authors: Gianluigi Savarese, Alessandra Dei Cas, Giuseppe Rosano, Carmen D'Amore, Francesca Musella, Susanna Mosca, Martin F. Reiner, Roberto Marchioli, Bruno Trimarco, Pasquale Perrone-Filardi Tags: Original Articles Source Type: research
Relative efficacy and safety of non-Vitamin K oral anticoagulants for non-valvular atrial fibrillation: Network meta-analysis comparing apixaban, dabigatran, rivaroxaban and edoxaban in three patient subgroups
Stroke is the most serious clinical consequence of atrial fibrillation, which is the most common cardiac arrhythmia. Non-vitamin K antagonist oral anticoagulants (NOACs) have emerged as efficacious, safe and convenient stroke prevention agents. This updated network meta-analysis focused on the relative efficacy and safety of apixaban compared with dabigatran, rivaroxaban and edoxaban for stroke prevention in (i) patients with CHADS2 score ≥2, (ii) secondary stroke prevention, and (iii) patients with high quality anticoagulation control with warfarin.
Source: International Journal of Cardiology - November 17, 2015 Category: Cardiology Authors: Gregory Y.H. Lip, Stephen A. Mitchell, Xianchen Liu, Larry Z. Liu, Hemant Phatak, Sumesh Kachroo, Sarah Batson Source Type: research
Screening for atrial fibrillation in the elderly
Any screening program in the community, while providing useful and previously unknown information, has the potential of uncovering findings of uncertain interpretation, especially regarding their impact on clinical outcomes, and therefore the justification of extending the screening to larger cohorts with substantial health care costs. As Shang and colleagues [1] remind us, the STROKESTOP study [2] detected a modest benefit from screening for atrial fibrillation (AF) on the primary combined endpoint of ischaemic or haemorrhagic stroke, systemic embolism, bleeding leading to hospitalisation and all-cause death (1.1% absolut...
Source: International Journal of Cardiology - November 2, 2021 Category: Cardiology Authors: Carlo Mannina, Marco R. Di Tullio Tags: Letter to the Editor Source Type: research
Impact of non-steroidal anti-inflammatory drugs (NSAIDs) on cardiovascular outcomes in patients with stable atherothrombosis or multiple risk factors
Abstract: Background: We aimed to assess whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of cardiovascular (CV) events in stable patients with established atherothrombosis or multiple risk factors.Methods: We analysed the 23,728 European patients of the REACH Registry; 20,588 (86.8%) had established atherothrombotic disease and 3140 (13.2%) had multiple risk factors only. Aspirin (ASA) and/or NSAIDs use was determined at enrolment and ischemic events were recorded over two years of follow-up. cMACCE was defined as the composite of CV death, MI or stroke. Bleeding was d...
Source: International Journal of Cardiology - June 30, 2011 Category: Cardiology Authors: Olivier Barthélémy, Tobias Limbourg, Jean Philippe Collet, Farzin Beygui, Johanne Silvain, Anne Bellemain-Appaix, Guillaume Cayla, Thomas Chastre, Iris Baumgartner, Joachim Röther, Uwe Zeymer, Deepak L. Bhatt, Gabriel Steg, Gilles Montalescot, On behal Tags: Original Articles Source Type: research
Excess risk of mortality and cardiovascular events associated with smoking among patients with diabetes: Meta-analysis of observational prospective studies
Conclusion: Smoking amplified the risk of mortality as well as cardiovascular events and the effect size for CHD appeared to be higher than other events in diabetic patients. Moreover, a trend of decreasing risk was observed among smoking quitters.
Source: International Journal of Cardiology - January 18, 2012 Category: Cardiology Authors: Rui Qin, Tao Chen, Qingqing Lou, Dahai Yu Tags: Original Articles Source Type: research
Atrial fibrillation management, outcomes and predictors of stable disease in daily practice: Prospective non-interventional study
Conclusions: The relatively low proportion of stable patients and in particular, the high hospitalization and stroke rate indicate difficulties in everyday management of patients with AF.
Source: International Journal of Cardiology - April 4, 2012 Category: Cardiology Authors: Ralph F. Bosch, Wilhelm Kirch, Juergen-Detlef Theuer, David Pittrow, Annette Kohlhaußen, Stefan N. Willich, Hendrik Bonnemeier Tags: Original Articles Source Type: research
