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Female gender and atrial fibrillation: An association with worse prognosis and outcomes
Females with atrial fibrillation (AF) are at increased risk for ischemic stroke but have been under-represented in AF cohorts. Without anticoagulation, women are at higher risk than men for AF-related thromboembolic events (TE) but results are not consistent [1,2]. Interestingly, vascular complication rates after AF ablation had been recently shown to be also higher in females [3]. Female sex has been included in the CHA2DS2-VASc score for assessing thromboembolic risk, which doubles in women between the ages of 55 and 65, the menopausal period, when estradiol levels decrease by about 60% [4].
Source: International Journal of Cardiology - February 24, 2015 Category: Cardiology Authors: Jelena Kornej, Andreas Bollmann, Gerhard Hindricks, Gregory Y.H. Lip Tags: Letter to the Editor Source Type: research

Hyperpolarization-activated current-mediated slow afterhyperpolarization in myelinated Ah-type of baroreceptor neurons isolated from adult female rats
Compelling evidence indicates that baroreceptor/baroreflex dysfunction closely impacts on hypertension and CNS disorder, such as stroke . Baroreceptor neurons, with their mechanosensitive terminals and cell bodies located in aortic arch and nodose ganglia, receive the signals regarding blood pressure change and regulate the blood pressure quickly and efficiently through the baroreflex. Mechanosensitive terminals encode the pressure response into repetitive discharge that is received by baroreceptor neurons with various frequencies depending upon the blood pressure. From clinical point of view, nerve degenerative, such as P...
Source: International Journal of Cardiology - January 17, 2014 Category: Cardiology Authors: Li-Min Han, Tao Ban, Yang Liu, Mei Yuan, Jian-Li He, Xin Wen, Zhao Qian, Guo-Fen Qiao, Bai-Yan Li Tags: Online Letters to the Editor Source Type: research