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Ce-452772-3 self-pulse exam for atrial fibrillation screening: a randomized controlled trial
Atrial fibrillation (AF), the most commonly treated cardiac arrhythmia, is associated with significant morbidity including the potential for stroke. Because AF is often asymptomatic, there is growing interest in AF screening. Trials of AF screening using external monitors, smartwatches, or other personal electronic devices have shown that screening increases detection of AF. Due to the cost and low yield of screening with insufficient evidence of clinical benefit, the US Preventative Services Task Force has not recommended comprehensive screening for AF at the current time.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Benjamin Chilcutt, Taylor C. Bazemore, Tiffany Armbruster, Ari Becker, Wanting Jin, Quefeng Li, Anil K. Gehi Source Type: research

Po-01-108 elucidating the mechanism of atrial fibrillation in lamin a/c heart disease using human ipsc-derived atrial cardiomyocytes
Mutations in the LMNA gene, encoding the nuclear envelope proteins lamin A/C, cause cardiac arrhythmias, conduction disease, and dilated cardiomyopathy. Malignant arrhythmias such as atrial fibrillation (AF) and ventricular tachycardia are common and pose an increased risk of stroke and sudden cardiac death.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: William Janes, Asia Owais, Hanna Chen, Yining Chen, Michael Hill, Dawood Darbar, Srinath Yeshwant Source Type: research

Po-716-02 short term readmission rates and clinical outcomes of anticoagulation versus watchman device in octogenarians
Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia with prevalence increasing with age. Left atrial appendage occlusion (LAAO) with watchman device has been found to be noninferior to oral anticoagulation for long-term stroke risk reduction in patients with AF. Patients greater than 80 years of age have been underrepresented in most of these trials making application of findings challenging in this subset of patients.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Varun Victor, Mahmoud Khalil, Ahmed Mohamed, Kirolos Barssoum Source Type: research

Connexin45 (GJC1) loss-of-function mutation contributes to familial atrial fibrillation and conduction disease
Atrial fibrillation (AF) represents the most common clinical cardiac arrhythmia and substantially increases the risk for cerebral stroke, heart failure and death. Although causative genes for AF have been identified, the genetic determinants for AF remain largely unclear.
Source: Heart Rhythm - January 8, 2021 Category: Cardiology Authors: Ruo-Gu Li, Ying-Jia Xu, Willy G. Ye, Yan-Jie Li, Honghong Chen, Xing-Biao Qiu, Yi-Qing Yang, Donglin Bai Source Type: research

Atrial Fibrillation and Cognitive Decline —Another Piece for a Big Puzzle
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is increasing over time.1, 2 AF is associated with an increased risk of stroke,3 heart failure,4 and death.5-7 In recent years, evidence has emerged to indicate that AF is associated with another growing public health problem: cognitive impairment and dementia.8 Although the evidence is compelling, existing studies suffer from several limitations such as reliance on the Mini-Mental State Examination, cross-sectional design, and lack of attention to domain-specific changes.
Source: Heart Rhythm - October 10, 2017 Category: Cardiology Authors: Lin Y. Chen, Win-Kuang Shen Source Type: research

Atrial fibrillation and cognitive decline: Another piece for a big puzzle
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is increasing over time.1,2 AF is associated with an increased risk of stroke,3 heart failure,4 and death.5 –7 In recent years, evidence has emerged to indicate that AF is associated with another growing public health problem: cognitive impairment and dementia.8 Although the evidence is compelling, existing studies suffer from several limitations, such as reliance on the Mini-Mental State Examination, c ross-sectional design, and lack of attention to domain-specific changes.
Source: Heart Rhythm - October 10, 2017 Category: Cardiology Authors: Lin Y. Chen, Win-Kuang Shen Tags: Editorial Commentary Source Type: research

Utility and Limitations of Long-Term Monitoring of Atrial Fibrillation Using an Implantable Loop Recorder
Atrial fibrillation (AF) is the most common cardiac arrhythmia diagnosed and treated in the world. The treatment of patients ’ symptoms as well as the prevention of stroke and heart failure is dependent on accurate detection and characterization of AF. A variety of electrocardiographic (ECG) monitoring techniques are being used for these purposes. However, these intermittent ECG monitoring techniques have been shown to under diagnose AF events, while having limited ability to characterize AF burden and density.
Source: Heart Rhythm - September 13, 2017 Category: Cardiology Authors: Randall Lee, Suneet Mittal Source Type: research

Pacing for treatment and prevention of atrial fibrillation: Is there an end to this story?Editorial Commentary
Pacemakers are frequently implanted in patients with atrial fibrillation (AF), which is the most common sustained cardiac arrhythmia with causal association with stroke, heart failure, cardiomyopathy, and all-cause mortality.1–5 In a general pacemaker population, AF can also develop frequently and progressively over time.6 Thus, as no surprise, the story of “pacing and AF” has been going around for a long time.1–7 The article by Padeletti et al8 in this issue of HeartRhythm perhaps adds a new twist.
Source: Heart Rhythm - May 5, 2015 Category: Cardiology Authors: Bharat K. Kantharia Tags: Editorial Commentary Source Type: research

Left atrial appendage closure: A new technique for clinical practice
Conclusion: This review concludes that it is now appropriate to consider these techniques for patients with AF who are at high risk for stroke for whom effective conventional or novel anticoagulant therapy is not available or who present problems in managing drug treatment.
Source: Heart Rhythm - December 2, 2013 Category: Cardiology Authors: A John Camm, Antonio Colombo, Giorgio Corbucci, Luigi Padeletti Tags: Contemporary Review--Section Editor: Sami Viskin Source Type: research

Platelet-derived growth factor: A promising therapeutic target for atrial fibrillation
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is characterized by substantial electrophysiological and structural changes. AF is associated with an increased risk of stroke, heart failure, and overall mortality. The risk of developing AF increases with age and with other risk factors such as diabetes and underlying heart disease. Currently, the therapeutic options for the treatment of AF have moderate effectiveness, and side effects, including proarrhythmic events, can often be encountered. The limited effectiveness of antiarrhythmic drugs available for the management of AF is especially proble...
Source: Heart Rhythm - April 8, 2013 Category: Cardiology Authors: Céline Fiset Tags: Editorial Commentary Source Type: research

MicroRNAs emerging as mediators of remodeling with atrial fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is now established as an independent risk factor for stroke. Moreover, a concomitant diagnosis of AF greatly complicates treatment for a number of disease processes such as diabetes and congestive heart failure. Given the recognized additional burden that AF places on the health-care system, significant research has been performed in an attempt to delineate mechanisms that contribute to AF initiation as well as progression. Understandably, there is an extensive body of research that has identified abnormalities in ionic channels/electrogenic processes that ...
Source: Heart Rhythm - March 25, 2013 Category: Cardiology Authors: Adam W. Akerman, Rupak Mukherjee Tags: Editorial Commentary Source Type: research

Toward permanent pulmonary vein isolation: The use of adenosine to unmask dormant conduction
Atrial fibrillation (AF) remains the most common sustained cardiac arrhythmia and continues to be a major cause of stroke and hospitalizations worldwide. Seminal observations by Haïssaguerre et al in 1998 on the role of pulmonary vein (PV) triggers in AF led to the development of PV isolation as the cornerstone of ablation for AF. However, this initial enthusiasm has been dampened by the high frequency of PV reconnection, resulting in recurrent AF. Therefore, permanent PV isolation remains the “holy grail” for electrophysiologists. The quest for permanent PV isolation has resulted in the development of numerous techno...
Source: Heart Rhythm - February 4, 2013 Category: Cardiology Authors: Kim H. Chan, Raymond W. Sy Tags: Editorial Commentary Source Type: research