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Po-05-169 ventricular scar by cardiac mri is a predictor of atrial fibrillation in hypertrophic cardiomyopathy
Atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM) increases risk of stroke and mortality. The reported prevalence of AF in HCM ranges from 18% to 28%, which is higher than the general population; even after accounting for traditional risk factors including obesity, hypertension, and age. Several factors increase risk of AF in HCM including left atrial size and the presence of ventricular obstruction. However, there is paucity of data correlating ventricular late gadolinium enhancement (LGE) to the incidence of AF in HCM.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Joseph Banno, David Fermin, Dana Marsy, Nabin Manandhar Shrestha, Richard McNamara, Jeffrey Decker, Alfred J. Albano, Jose Tan, Laura Franey, Wissam Abdallah, Christopher Madison, Renzo Loyaga Rendon, Nagib T. Chalfoun Source Type: research

Morbid Obesity is Associated with Increased Procedural Complications and Worse In-Hospital Outcomes after Percutaneous Left Atrial Appendage Occlusion Device Implantation
Obesity has adverse effects on cardiovascular hemodynamics and is an independent risk factor for the induction and perpetuation of atrial fibrillation (AF) (1). Percutaneous left atrial appendage occlusion (LAAO) has shown promising results in reducing stroke risk in select AF patients who cannot be managed with a conventional long-term oral anticoagulation strategy (2). In the landmark PROTECT-AF trial evaluating the efficacy and safety of percutaneous LAAO, patients receiving LAAO device had a mean BMI of 31.6 kg/m2 (2), however, no distinct assessment of outcomes were conducted based on body weight.
Source: Heart Rhythm - December 26, 2022 Category: Cardiology Authors: Siddharth Agarwal, Zain Ul Abideen Asad, Muhammad Zia Khan, Lydia Fekadu Messele, Douglas Darden, Deepak Kumar Pasupula, Gagan D. Singh, Uma N. Srivatsa, Salman Zahid, Sudarshan Balla, Christopher V. DeSimone, Abhishek Deshmukh, Muhammad Bilal Munir Source Type: research

Hp-574-04 associations between obesity parameters and the risk of incident atrial fibrillation and ischemic stroke in different age groups: a nationwide population-based study
Atrial fibrillation (AF) and ischemic stroke (IS) are two representative cardiovascular diseases. They share common metabolic risk factors such as obesity and ageing is an important predisposing factor. Limited data comprehensively evaluated the relationship between obesity measurements - body mass index (BMI) and waist circumference (WC) - and incident AF and IS in the different age groups.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Hyo-Jeong Ahn, So-Ryoung Lee, Eue-Keun Choi, Soonil Kwon, Sun-hwa Kim, Seil Oh, Gregory Lip Source Type: research

Po-718-05 prescribing patterns of direct anticoagulants versus vitamin k antagonists in patients with non-valvular atrial fibrillation and extreme obesity
Anticoagulation is an effective treatment in prevention of stroke in patients with atrial fibrillation (AF). Direct anticoagulants (DOACs) have been favored over vitamin K dependent antagonists (VKAs) given their safety and efficacy. However, there is limited real-world data on DOAC use among patients with extreme obesity.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Sherry J. Saxonhouse, Kamala SWAYAMPAKALA, Stephen Perle, Sophia E. Saxonhouse Source Type: research

Strategies to balance stroke and bleeding risk in patients with atrial fibrillation and cancer
A 76-year-old female with obesity, hypertension, persistent atrial fibrillation, and heart failure with preserved ejection fraction is started on ibrutinib 420 mg once daily for Waldenstrom ’s macroglobulinemia. Due to concern for drug-drug interactions, her amiodarone is decreased from 200 to 100 mg daily, and she is continued on metoprolol succinate 100 mg daily and apixaban 5 mg twice daily. She presents to the clinic one month later with extensive superficial ecchymoses, and her apixaban dose is reduced to 2.5 mg twice daily due to concerns that this may reflect the combined antiplatelet effects of ibrutinib and anti...
Source: Heart Rhythm - April 27, 2021 Category: Cardiology Authors: Shiv Bagga, Sourbha S. Dani, Bruce G. Hook, Anju Nohria, Sarju Ganatra Source Type: research

Who is at risk of atrial fibrillation?
Atrial fibrillation (AF) is a common cause of stroke, with prevalence increasing alongside the aging of our population [1]. Increasing age, hypertension, obesity, heart failure, sleep apnea, diabetes, coronary disease, chronic kidney disease and smoking account for much of the global risk of AF [2 3]. Incident AF is also predicted by both rare and common genetic variants, many of which encode for cardiac structural and electrical proteins, as well as by more complex heritable traits such as height, obesity and race [4-6].
Source: Heart Rhythm - February 24, 2021 Category: Cardiology Authors: Jeff S. Healey, Jason D. Roberts, Thalia S. Field Source Type: research

Accessory Pulmonary Vein Insertion into the Left Atrial Appendage Revealed During Intended Interventional LAA Occlusion
A 64-year-old male with paroxysmal atrial fibrillation and a recent stroke presented with internal carotid artery re-stenosis after prior angioplasty. Cardiovascular risk factors included arterial hypertension, hyperlipidemia, obesity, positive family history, heart failure, and active smoking. Due to high risk of cerebral ischemia as well as periinterventional bleeding complications, the patient was scheduled for interventional left atrial appendage (LAA) closure prior to carotid artery surgery.
Source: Heart Rhythm - July 30, 2018 Category: Cardiology Authors: Octavian Maniuc, Jonas M üntze, Maria Moritz, Peter Nordbeck Source Type: research

The metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

The Metabolic Syndrome, Atrial Fibrillation and Stroke: Tackling An Emerging Epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of metabolic syndrome. Metabolic syndrome describes an association between diabetes, hypertension, obesity, dyslipidaemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory YH Lip Tags: CRV Source Type: research

Metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

I left my smartphone at home and can’t tell if I’m in atrial fibrillation
The enormous impact of atrial fibrillation (AF) on human suffering, health-care utilization, and physician resources is clear to the readers of HeartRhythm. Recent publications have developed 3 alarming trends: (1) the incidence of AF is increasing, perhaps fueled by the obesity epidemic; (2) our ability to treat AF is not improving, at least as assessed by age-adjusted mortality rates postdiagnosis; and (3) health-care costs for treatment of AF are growing exponentially. In reaction to these depressing facts, the tendency to want to learn more about our enemy is only natural. Improvements in bioengineering technology and ...
Source: Heart Rhythm - January 28, 2013 Category: Cardiology Authors: David J. Callans Tags: Editorial Commentary Source Type: research