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Source: Heart Rhythm
Condition: Heart Failure
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Total 48 results found since Jan 2013.
Blocking interleukin-6 Trans-Signaling in AF: Promises and Challenges
Atrial fibrillation (AF) stands as the most prevalent cardiovascular disease, posing significant risks of stroke, heart failure, and other complications that contribute to morbidity and mortality. While traditionally research on AF has primarily focused on electrophysiological components like ionic currents and the Ca2+ handling system, treatment strategies have mainly revolved around the rate-limiting beta-blockers and Ca2+ channel blockers, or rhythm-control methods such as cardioversion, antiarrhythmics, and catheter ablation.
Source: Heart Rhythm - September 9, 2023 Category: Cardiology Authors: Enrique Martinez, Na Li Source Type: research
Po-04-144 impact of age on atrial arrhythmia outcomes after percutaneous asd closure
Atrial Septal Defects (ASD) are one of the most common congenital heart defects, and if unrepaired, increase the risk of atrial fibrillation (AF) and atrial flutter (AFL). AF/AFL are linked to an increased risk of stroke and heart failure yet, it is not clear from existing data whether percutaneous ASD closure reduces the overall burden of AF/AFL and whether AF/AFL prevalence is impacted by closure age.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Brendan Burke, Ghazaleh Goldar, Jeevanantham Rajeswaran, Alex Milinovich, Olivia McCloskey, Patricia Blazevic, Peter F. Aziz, Tara Karamlou, Mohamed Kanj, Patcharapong Suntharos, Joanna Ghobrial Source Type: research
Ce-452772-4 delayed detection of and intervention for incident af in hospitalized patients is common and consequential
Incident atrial fibrillation (AF) affects c.10% of hospitalized patients. Early AF management mitigates risk of complications (e.g. stroke, heart failure, care escalation) yet recognition and intervention is sub-optimal. Prior work here showed a median 1.5 day delay from automated algorithmic AF detection to clinical action in the ICU.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Daniel Soto, Nicholas Van Dyke, Nick Prinz, Randall Moorman, Oliver J. Monfredi Source Type: research
Po-05-185 prediction and risk of atrial fibrillation in patients with hypertrophic cardiomyopathy: a danish nationwide cohort study
Hypertrophic cardiomyopathy (HCM) can be associated with serious complications such as heart failure, atrial fibrillation (AF) and sudden cardiac death. The treatment of AF in HCM patients can be challenging since AF often aggravates symptoms and increases the risk of stroke. Little is known on which factors contribute to the development of AF in these patients.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Christopher Z örner, Jannik L. Pallisgaard, Anne-Marie Schjerning, Morten K. Jensen, Jacob Tønnesen, Lise D. Vestergaard, Peter Vibe Rasmussen, Gunnar Gislason, Morten L. Hansen Source Type: research
Po-05-141 association of interatrial block and the development of atrial fibrillation among patients with hypertrophic cardiomyopathy
Atrial fibrillation (AF) is the most common sustained arrhythmia among those with hypertrophic cardiomyopathy (HCM), affecting 1 in 5 patients. The combination of HCM and AF is associated with an increased risk of stroke, heart failure, and mortality. Interatrial block (IAB) is a distinct electrocardiographic (ECG) pattern describing conduction delay between the right and left atria through Bachmann ’s bundle. IAB has been identified as a predictor of AF across several disease states including congestive heart failure, valvular disease, and cardiac amyloidosis.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Abdullah Alissa, Nadia Bokhari, Munther K. Homoud, Ethan Rowin, Martin S. Maron, Christopher Madias Source Type: research
Po-703-07 improved left ventricular ejection fraction and stroke volume with his bundle pacing are associated with higher magnitudes of global longitudinal and circumferential strains
In recently reported clinical studies, His bundle pacing (HBP) improved cardiac function in patients with pre-existing heart failure. The effect of HBP vs RBP on global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in the absence of pre-existing heart failure has not yet been explored.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Muhammad Shuja Khan, Annie Hirahara, Yuki Ishidoya, Ravi Ranjan, Derek J. Dosdall Source Type: research
En-571-02 screening for putative pathogenic variants in dilated cardiomyopathy genes identifies early disease and predicts mortality
Dilated cardiomyopathy (DCM) can present with the sentinel event of sudden cardiac death, as well as heart failure, ECG abnormalities, atrial fibrillation or stroke. Data are limited regarding genetic screening and the mortality associated with DCM in a general population.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Ravi Shah, Babken Asatryan, Ghaith Sharaf Dabbagh, Mohammed Khanji, Stefan van Duijvenboden, Daniele Muser, Andrew Paul Landstrom, Christopher Semsarian, Virend Somers, Patricia B. Munroe, Anwar A. Chahal Source Type: research
Po-641-05 safety and in-hospital outcomes of left atrial appendage closure device in patients with heart failure: an analysis from the national inpatient sample database 2015-2018
Left atrial appendage occlusion (LAAO) is a procedure that has been shown to be non-inferior to oral anticoagulation for stroke prevention for patients with atrial fibrillation. There is limited data about the safety of left atrial appendage occlusion (LAAO) in patients with heart failure (HF).
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Carlos Vergara Sanchez, Michael Dangl, Michael Albosta, Ian Ergui, Karla Inestroza, Jennifer Maning, Louis Thomas Vincent, Jelani K. Grant, Bertrand Ebner, Rosario Colombo Source Type: research
Po-661-07 a photoplethymography-based approach to atrial fibrillation-burden estimation in high-risk patients
Atrial fibrillation (AF) is the most common arrhythmia leading to hospital admission. Its incidence is linked to increased risk of stroke, congestive heart failure, and overall mortality. AF burden is a key determinant of outcomes, but accurate quantification can be limited by the cardiac monitoring period (typically days). Alternatively, longer-term monitoring comes at higher cost and often requires an invasive approach. The introduction of reliable wrist-worn devices may improve access to long-term monitoring of AF burden.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Charles A. Athill, Yuriko Tamura, Steven Szabados, Anthony Battisti, Jeffrey Ellis, Lori Crosson, Judith C. Lenane Source Type: research
Po-661-03 use of a deep learning algorithm to predict paroxysmal atrial fibrillation based on printed electrocardiographic records acquired during sinus rhythm
Atrial fibrillation (AF) is a common type of sustained arrhythmia worldwide. Asymptomatic AF, which occurs frequently, is associated with an increased incidence of ischemic stroke, heart failure, and mortality. A large number of patients with paroxysmal atrial fibrillation (PAF) remain undiagnosed due to the absence of electrocardiographic evidence of AF (AF-ECGs). If PAF could be predicted, targeted screening could improve early detection and treatment of this condition.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Yang Zhou, Yu Chen, Deyun Zhang, Shijia Geng, Guodong Wei, Ying Tian, Shenda Hong, XINGPENG LIU Source Type: research
New frontiers for improving outcomes after transcatheter aortic valve implantation: the role of the conduction system and the impact of pacemakers
Transcatheter aortic valve implantation (TAVI) is at least as safe and effective as surgical aortic valve replacement (SAVR) in patients with severe symptomatic aortic stenosis for the endpoints of all-cause mortality, stroke and heart failure hospitalizations across the spectrum of surgical risk1,2. Despite iterative advances in technology and refinements in procedural technique, conduction disturbances are not infrequent and occur more commonly after TAVI than after surgery. In the most recent low-risk randomized trials2,3 comparing TAVI to SAVR, the rates of permanent pacemaker implantation (PPI) were 6.6% with the ball...
Source: Heart Rhythm - August 18, 2021 Category: Cardiology Authors: Yousif Ahmad, Raj Makkar Source Type: research
EP News: Clinical
Rillig et al (Circulation July 30, 2021; https://doi.org/10.1161/CIRCULATIONAHA.121.056323, PMID: pending) assessed the effect of early rhythm control (ERC) therapy (using antiarrhythmic drugs or catheter ablation) compared to usual care (UC; allowing rhythm control therapy to improve symptoms) on outcomes in prespecified patients with heart failure in the EAST-AFNET 4 trial. During 5.1-year follow-up, the composite primary outcome of cardiovascular death, stroke, or hospitalization for worsening of heart failure or for acute coronary syndrome occurred less often in patients randomized to ERC therapy (94/396; 5.7 per 100...
Source: Heart Rhythm - August 8, 2021 Category: Cardiology Authors: N.A. Mark Estes Tags: EP News Source Type: research
B-po03-186 monitoring atrial fibrillation patients using active contactless videoplesthymography implemented on a personal tablet
Early detection of subclinical AF can help prevent significant complications such as embolic stroke, heart failure, and AF-related hospitalizations.
Source: Heart Rhythm - July 28, 2021 Category: Cardiology Authors: Jean-Philippe Y. Couderc, Gill Tsouri, Celal Savur, John Decamila Xiajuan Xia, Kamil Bukum Betty Mykins, Burr W. Hall Source Type: research
Strategies to balance stroke and bleeding risk in patients with atrial fibrillation and cancer
A 76-year-old female with obesity, hypertension, persistent atrial fibrillation, and heart failure with preserved ejection fraction is started on ibrutinib 420 mg once daily for Waldenstrom ’s macroglobulinemia. Due to concern for drug-drug interactions, her amiodarone is decreased from 200 to 100 mg daily, and she is continued on metoprolol succinate 100 mg daily and apixaban 5 mg twice daily. She presents to the clinic one month later with extensive superficial ecchymoses, and her apixaban dose is reduced to 2.5 mg twice daily due to concerns that this may reflect the combined antiplatelet effects of ibrutinib and anti...
Source: Heart Rhythm - April 27, 2021 Category: Cardiology Authors: Shiv Bagga, Sourbha S. Dani, Bruce G. Hook, Anju Nohria, Sarju Ganatra Source Type: research
Anti-diabetic drugs for preventing atrial fibrillation: a new revolution?
Type 2 diabetes mellitus (DM) and atrial fibrillation (AF) are two of the great epidemics of our time. DM affects and estimated 8.5% of adults in the US1, and is associated with an increased risk of cardiovascular events, including AF.2 AF in turn affects an estimated up to 12.5% of adults over age 65 years in the US, decreases quality of life and increases the risks of heart failure, stroke and death 3,4. In 2015, the EMPA-REG OUTCOME randomized controlled trial (RCT), assessing a sodium glucose co-transporter 2 inhibitor (SGLT-2i), sparked interest in the therapeutic potential for oral anti-diabetic agents to reduce card...
Source: Heart Rhythm - April 7, 2021 Category: Cardiology Authors: William F. McIntyre, Jeff S. Healey Source Type: research
