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Po-02-093 impact of ablation outcome on cognitive function in patients with atrial fibrillation
Emerging evidences suggest increased risk of all forms of dementia in patients with atrial fibrillation (AF) even in the absence of overt stroke. Cerebral hypoperfusion and the risk of cerebrovascular micro- and macro-embolism are plausible explanations for the predisposition for cognitive decline in AF.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Sanghamitra Mohanty, Angel Quintero Mayedo, Bryan MacDonald, Carola Gianni, VincenzoMirco La Fazia, Domenico G. Della Rocca, Prem Geeta Torlapati, Mohamed A. Bassiouny, G. Joseph Gallinghouse, John D. Burkhardt, Rodney P. Horton, Amin Al-Ahmad, Xiaodong Z Source Type: research

Po-05-197 association of genetic risk of atrial fibrillation and dementia
Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. However, precise mechanism of this association is not well-known and studies that examine the association of genetic susceptibility of AF and dementia is scarce.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Dongmin Kim, Juntae Kim, Eunsun Jang, Daehoon Kim, Hee Tae Yu, Myung-Yong Lee, Pil-Sung Yang, Boyoung Joung Source Type: research

Po-649-08 impact of ablation outcome on cognitive function in patients with atrial fibrillation
Emerging evidences suggest increased risk of all forms of dementia in patients with atrial fibrillation (AF) even in the absence of overt stroke.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Sanghamitra Mohanty, Angel Quintero Mayedo, Bryan MacDonald, Carola Gianni, Domenico G. Della Rocca, Faiz Baqai, Mohamed A. Bassiouny, G. Joseph Gallinghouse, J. David Burkhardt, Rodney P. Horton, Rong Bai, Amin Al-Ahmad, Andrea Natale Source Type: research

Po-669-06 brain metabolism in patients with atrial fibrillation: insights from a pilot fdg-pet study
Atrial Fibrillation (AF) is an independent risk factor for incident dementia. Overt stroke, microembolism and microbleeds are among the main mechanisms linking this arrhythmia and cognitive dysfunction. Cerebral hypoperfusion related to beat-to-beat blood flow variation during AF can also explain the occurrence of dementia or mild cognitive impairment, as rhythm control strategies were shown to reduce its incidence. However, data regarding brain metabolism patterns in patients with AF are still scarce.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Gabriel Targueta, Vitor Delgado, Marcelo Melo, FRANCISCO CARLOS DA COSTA DARRIEUX Source Type: research

Stroke and Dementia Risk in Patients with and without Atrial Fibrillation and Carotid Arterial Disease
We sought to understand the risks of stroke, transient ischemic attack(TIA), and dementia in patients with and without atrial fibrillation (AF) and carotid arterial disease (CD), or a combination of both, and determine if therapies for each disease may influence risks. 11,572 patients were included and matched into 4 groups of 2,893 by the presence of AF and CD. CD and AF augment risk of stroke/TIA and dementia in the general population and the coexistence of both diseases is additive in risk. Ablation of AF was associated with lower risk, the magnitude of which was greater in those with CD.
Source: Heart Rhythm - July 8, 2019 Category: Cardiology Authors: T. Jared Bunch, Tami L. Bair, Brian G. Crandall, Michael J. Cutler, John D. Day, Kevin G. Graves, Victoria Jacobs, Charles Mallender, Jeffrey S. Osborn, J. Peter Weiss, Heidi T. May Source Type: research

CHA2DS2-VASc scores and Intermountain Mortality Risk Scores for the joint risk stratification of dementia among patients with atrial fibrillation
High CHA2DS2-VASc scores in atrial fibrillation (AF) patients are generally associated with increased risks of stroke and dementia. At lower CHA2DS2-VASc scores, there remains an unquantifiable cranial injury risk, necessitating an improved risk assessment method within these lower-risk groups.
Source: Heart Rhythm - January 1, 2019 Category: Cardiology Authors: Kevin G. Graves, Heidi T. May, Victoria Jacobs, Kirk U. Knowlton, Joseph B. Muhlestein, Donald L. Lappe, Jeffrey L. Anderson, Benjamin D. Horne, T. Jared Bunch Tags: Featured Article Source Type: research

Seeing is Believing: The Importance of Continuous Monitoring to Unmask the Real-World Atrial Fibrillation Recurrence after Ablation
Atrial fibrillation (AF) is a common arrhythmia encountered in clinical practice that contribute to hemodynamic abnormalities, thromboembolic events and hospitalizations.1 The prevalence of AF is around 1% in the general population, substantially increases with age and is estimated to reach 4% in 2050.2, 3 Compared with patients without AF, patients with AF has an increased risk of dementia (hazard ratio [HR]=1.56), myocardial infarction (HR=1.62), sudden cardiac death (HR=1.83), mortality (HR=2.61), heart failure (HR=3.31) and ischemic stroke (HR=3.34).
Source: Heart Rhythm - July 28, 2018 Category: Cardiology Authors: Ting-Yung Chang, Chin-Yu Lin, Shih-Ann Chen Source Type: research

Atrial Fibrillation and Cognitive Decline —Another Piece for a Big Puzzle
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is increasing over time.1, 2 AF is associated with an increased risk of stroke,3 heart failure,4 and death.5-7 In recent years, evidence has emerged to indicate that AF is associated with another growing public health problem: cognitive impairment and dementia.8 Although the evidence is compelling, existing studies suffer from several limitations such as reliance on the Mini-Mental State Examination, cross-sectional design, and lack of attention to domain-specific changes.
Source: Heart Rhythm - October 10, 2017 Category: Cardiology Authors: Lin Y. Chen, Win-Kuang Shen Source Type: research

Atrial fibrillation and cognitive decline: Another piece for a big puzzle
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is increasing over time.1,2 AF is associated with an increased risk of stroke,3 heart failure,4 and death.5 –7 In recent years, evidence has emerged to indicate that AF is associated with another growing public health problem: cognitive impairment and dementia.8 Although the evidence is compelling, existing studies suffer from several limitations, such as reliance on the Mini-Mental State Examination, c ross-sectional design, and lack of attention to domain-specific changes.
Source: Heart Rhythm - October 10, 2017 Category: Cardiology Authors: Lin Y. Chen, Win-Kuang Shen Tags: Editorial Commentary Source Type: research

The power of P in the elderly: Small biphasic wave, big impact
With increasing life expectancy, the Beatles song “When I’m Sixty-Four” could be changed to “When I’m Ninety-Four” soon. Dementia and stroke, some of the most feared conditions in old age, are often caused by silent atrial fibrillation1,2 and may be heralded by changes in the P wave as suggested in the study by Martinez-Selles et al3 in this issue of HeartRhythm. The authors focus on P waves in centenarians over a century after the first description of the P wave. The authors report observations on interatrial block in centenarians, with implications well beyond this population.
Source: Heart Rhythm - November 18, 2015 Category: Cardiology Authors: Larissa Fabritz Tags: Editorial Commentary Source Type: research