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Impact of glucose-lowering therapies on risk of stroke in type 2 diabetes.
Abstract Patients with type 2 diabetes (T2D) have an increased risk of stroke compared with people without diabetes. However, the effects of glucose-lowering drugs on risk of ischaemic stroke in T2D have been less extensively investigated than in coronary heart disease. Some evidence, including the UKPDS, has suggested a reduced risk of stroke with metformin, although the number of studies is limited. Inhibition of the KATP channels increases ischaemic brain lesions in animals. This is in agreement with a recent meta-analysis showing an increased risk of stroke with sulphonylureas vs. various comparators as both m...
Source: Diabetes and Metabolism - May 15, 2017 Category: Endocrinology Authors: Bonnet F, Scheen AJ Tags: Diabetes Metab Source Type: research

Elevated triglyceride-glucose index predicts risk of incident ischaemic stroke: The Rural Chinese Cohort Study
CONCLUSION: Elevated TyG index is an independent predictor of ischaemic stroke in the general population, and insulin resistance may be positively associated with future stroke risk.PMID:33722769 | DOI:10.1016/j.diabet.2021.101246
Source: Diabetes and Metabolism - March 16, 2021 Category: Endocrinology Authors: Yang Zhao Haohang Sun Weidong Zhang Yuanlin Xi Xuezhong Shi Yongli Yang Lu Jie Ming Zhang Liang Sun Hu Dongsheng Source Type: research

Dipeptidyl peptidase-4 inhibitors and protection against stroke: A systematic review and meta-analysis.
CONCLUSION: The promising data from experimental studies regarding cardioprotective gliptin-associated effects against stroke were not supported by available data from trials specifically looking at cardiovascular safety. PMID: 27916514 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - November 30, 2016 Category: Endocrinology Authors: Barkas F, Elisaf M, Tsimihodimos V, Milionis H Tags: Diabetes Metab Source Type: research

Long-term risk of stroke in type 2 diabetes patients with diabetic ketoacidosis: A population-based, propensity score-matched, longitudinal follow-up study.
CONCLUSION: T2D patients with previous DKA have a higher risk of stroke, especially ischaemic strokes. PMID: 28129999 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - January 23, 2017 Category: Endocrinology Authors: Chen YL, Weng SF, Yang CY, Wang JJ, Tien KJ Tags: Diabetes Metab Source Type: research

Associations of MAFLD and MAFLD subtypes with the risk of the incident myocardial infarction and stroke
In conclusion, a diagnosis of MAFLD is associated with an increased risk of MI or stroke, and the assessment of MAFLD and its subtypes should be a component of the cardiovascular risk assessment.PMID:37586479 | DOI:10.1016/j.diabet.2023.101468
Source: Diabetes and Metabolism - August 16, 2023 Category: Endocrinology Authors: Shen Chen Hongliang Xue Rong Huang Ke Chen Haoyang Zhang Xu Chen Source Type: research

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