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Diastolic hypotension may attenuate benefits from intensive systolic targets: secondary analysis of a randomized controlled trial
The potential for harm due to excessive lowering of diastolic blood pressure as a result of antihypertensive treatment has been discussed for several decades.1 Numerous observational studies and secondary analyses of randomized data have suggested that treating diastolic blood pressure below a certain threshold may lead to adverse outcomes, including a higher incidence of coronary events, stroke, heart failure, and all-cause mortality.1 –6 Proposed mechanisms include reduced endocardial perfusion leading to coronary events,7 or flow limiting coronary stenosis.
Source: The American Journal of Medicine - June 12, 2018 Category: General Medicine Authors: Todd C. Lee, Rodrigo B. Cavalcanti, Emily G. McDonald, Louise Pilote, James M. Brophy Tags: A Clinical Research Study Source Type: research

Acute Stroke Imaging: What Clinicians Need to Know
Abstract: Advances in technology and software applications have contributed to new imaging modalities and strategies in the evaluation of patients with suspected acute cerebral infarction. Routine computed tomography (CT) and magnetic resonance imaging (MRI) have been the standard studies in stroke imaging, which have been complemented by CT and MR angiography, diffusion-weighted MR imaging, and cerebral perfusion studies, while conventional angiography is typically reserved for intra-arterial therapy. The purpose of this article is to review the variety of imaging studies available in the acute stroke setting, and to dis...
Source: The American Journal of Medicine - March 15, 2013 Category: Journals (General) Authors: Rihan Khan, Kambiz Nael, William Erly Tags: Reviews Source Type: research