Filtered By:
Source: The American Journal of Medicine

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 259 results found since Jan 2013.

Cryptogenic Strokes and Patent Foramen Ovales: What ’s The Right Treatment?
More than 25% of all ischemic strokes per year are cryptogenic; that is their cause is not determined after an appropriate evaluation.In 1988 it was reported that the incidence of a patent foramen ovale (PFO) was 30 to 40% in young patients with a cryptogenic stroke compared to 25% in the general population. This led to the suspicion that cryptogenic strokes were due to paradoxical embolism; that is a venous thrombus crossing a patent foramen ovale to enter the left atrium and then the arterial circulation.
Source: The American Journal of Medicine - August 22, 2016 Category: Journals (General) Authors: James E. Dalen, Joseph S. Alpert Tags: Review Source Type: research

Safety of Direct Oral Anticoagulants: Insights from Postmarketing Studies
Direct oral anticoagulants (DOACs) have been marketed in the United States since 2010. While numerous large-scale prospective phase 3 outcomes studies have documented the effectiveness of DOACs for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, the primary safety concern with all of these drugs —as it is with the more established oral anticoagulant warfarin—is the risk of major bleeding. Postmarketing surveillance studies (PMSS) provide the opportunity to evaluate the safety of these recently approved drugs across a spectrum of patients that may be broader than those in...
Source: The American Journal of Medicine - August 25, 2016 Category: Journals (General) Authors: Todd C. Villines, W. Frank Peacock Tags: Review Source Type: research

The Limited Public Health Impact of ‘Lifestyle’ Change
Two main factors are responsible for premature disease and mortality. One is smoking, often referred to as a “lifestyle choice,” but better described as a “habit.” The other is poor nutrition resulting largely from the sugar, alcohol, salt, and saturated fat content (SASS components) of ready-to-consume food and drink, much of which is manufactured on an industrial scale. Collectively, these dietar y components are the main drivers of the global epidemic of stroke, heart attack, obesity, and type 2 diabetes.
Source: The American Journal of Medicine - July 14, 2016 Category: Journals (General) Authors: Nicholas J. Wald Tags: Editorial Source Type: research

Preclinical and Clinical Data for Factor Xa and “Universal” Reversal Agents
Oral Factor Xa (FXa) inhibitors, a growing class of direct-acting anticoagulants, are frequently used to prevent stroke and systemic embolism in patients with atrial fibrillation and to prevent and treat venous thromboembolism. These drugs reduce the risk of clotting at the expense of increasing the risk of bleeding, and currently they have no specific reversal agent. However, andexanet  alfa, a recombinant modified FXa decoy molecule, is in a late-phase clinical trial in bleeding patients, and ciraparantag, a small molecule that appears to reverse many anticoagulants including the FXa inhibitors, is in development.
Source: The American Journal of Medicine - August 26, 2016 Category: Journals (General) Authors: Truman J. Milling, Scott Kaatz Tags: Review Source Type: research

Pointing to the diagnosis: hemorrhagic brain metastasis
The patient ’s symptoms and initial imaging results directed the original diagnosis towards hemorrhagic stroke, but this conclusion proved incorrect. A 65-year-old man presented with a 1-week history of dull headache, nausea, and vomiting. His medical history was significant for long-term hypertension and sta ge 1B lung adenocarcinoma. He had undergone lobectomy 6 months earlier.
Source: The American Journal of Medicine - September 11, 2016 Category: Journals (General) Authors: Yu-Hsiang Juan, Huei-Fang Hsuan, Yun-Chung Cheung, Shu-Hang Ng, Koon-Kwan Ng, Chin-Wei Yu, Yu-Ying Cheng, Yu-Ching Lin Tags: Images in Radiology Source Type: research

Future of the Palliative Care Workforce: Preview to an Impending Crisis
The specialty of palliative care has experienced remarkable acceptance over the last decade, with teams present in 85% of medium/large hospitals in the United States.1 For many serious illnesses like cancer, advanced heart disease, stroke, and chronic obstructive pulmonary disease, routine integration of palliative care is considered standard of care.
Source: The American Journal of Medicine - September 25, 2016 Category: Journals (General) Authors: Arif H. Kamal, Janet H. Bull, Keith M. Swetz, Steven P. Wolf, Tait D. Shanafelt, Evan R. Myers Tags: Editorial Source Type: research

Cryptogenic Strokes and Patent Foramen Ovales: What's the Right Treatment?
More than 25% of all ischemic strokes per year are cryptogenic, that is, their cause is not determined after an appropriate evaluation. In 1988, it was reported that the incidence of a patent foramen ovale was 30 to 40% in young patients with a cryptogenic stroke compared with 25% in the general population. This led to the suspicion that cryptogenic strokes were due to paradoxical embolism, that is, a venous thrombus crossing a patent foramen ovale to enter the left atrium and then the arterial circulation.
Source: The American Journal of Medicine - August 22, 2016 Category: Journals (General) Authors: James E. Dalen, Joseph S. Alpert Tags: Review Source Type: research

Registries in Atrial Fibrillation: From Trials to Real-Life Clinical Practice
Recent improvements in atrial fibrillation diagnosis and management have prompted the initiation of various registries, predominantly to assess adherence to new guidelines, but also to address the pending questions of safety and effectiveness of newly introduced management options in ‘real world’ clinical practice settings. In this review we appraise antithrombotic treatment patterns for stroke prevention in atrial fibrillation registries.
Source: The American Journal of Medicine - October 12, 2016 Category: Journals (General) Authors: Micha ł Mazurek, Menno V. Huisman, Gregory Y.H. Lip Tags: Review Source Type: research

Non-vitamin K Antagonist Oral Anticoagulants for Cardioversion in Atrial Fibrillation – An Updated Meta-analysis
Non-vitamin K oral anticoagulants (NOACs) are now proven alternatives to vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF). However, there are few data on the efficacy and safety of their use around cardioversion, where the risk of thromboembolic events is heightened.
Source: The American Journal of Medicine - October 13, 2016 Category: Journals (General) Authors: Giulia Renda, Fabrizio Ricci, Raffaele De Caterina Tags: Clinical Research Study Source Type: research

Silent Atrial Fibrillation and Cryptogenic Strokes
A new suspected cause of cryptic strokes is “silent atrial fibrillation”.Pacemakers and other implanted devices allow continuous recording of cardiac rhythm for months or years. They have discovered that short periods of atrial fibrillation lasting minutes or hours are frequent and usually are asymptomatic.A meta-analysis of 50 studies in volving more than 10,000 patients with a recent stroke found that 7.7% had atrial fibrillation on their admitting EKG. In 3 weeks during and after hospitalization, another 16.9% were diagnosed.
Source: The American Journal of Medicine - October 14, 2016 Category: Journals (General) Authors: James E. Dalen, Joseph S. Alpert Tags: Review Source Type: research

Non-Vitamin K Antagonist Oral Anticoagulants for Cardioversion in Atrial Fibrillation: An Updated Meta-analysis
Non-vitamin K oral anticoagulants are now proven alternatives to vitamin K antagonists for stroke prevention in atrial fibrillation. However, there are few data on the efficacy and safety of their use for cardioversion, in which the risk of thromboembolic events is heightened.
Source: The American Journal of Medicine - October 13, 2016 Category: Journals (General) Authors: Giulia Renda, Fabrizio Ricci, Raffaele De Caterina Tags: Clinical research study Source Type: research

Salt, Tomato Soup and Hypocrisy of the American Heart Association
In no uncertain terms did the American Heart Association (AHA)[1] condemn a recent study by Mente et al. in the Lancet[2] : “The findings in this study are not valid” … “a flawed study”…” you shouldn’t use it to inform yourself about how you’re going to eat” read some of the statements in the AHA’s comment. The study in question suggested that salt restriction will only not benefit most people but m ay actually be harmful if salt intake becomes too low. Only in about 11% of the more than 100 000 study population, in patients who had high blood pressure, did salt restriction help to lower the risk of h...
Source: The American Journal of Medicine - November 20, 2016 Category: Journals (General) Authors: Franz H. Messerli, Stefano. F. Rimoldi, Sripal Bangalore Tags: Commentary Source Type: research

Salt, Tomato Soup, and the Hypocrisy of the American Heart Association
In no uncertain terms did the American Heart Association (AHA)1 condemn a recent study by Mente et  al2 in The Lancet: “The findings in this study are not valid” … “a flawed study” … “you shouldn't use it to inform yourself about how you're going to eat” read some of the statements in the AHA's comment. The study in question suggested that not only will salt restriction not benef it most people, but it may actually be harmful if salt intake becomes too low. In only about 11% of the more than 100,000 study population, in patients who had high blood pressure, did salt restriction help to lower the risk of he...
Source: The American Journal of Medicine - November 20, 2016 Category: Journals (General) Authors: Franz H. Messerli, Stefano F. Rimoldi, Sripal Bangalore Tags: Commentary Source Type: research

Wunderlich Syndrome
A 55-year-old man presented to the Emergency Department with severe abdominal pain for 1 day. He had a history of hypertension, diabetes mellitus, and ischemic stroke. The pain was severe, sharp, and constant, in his left flank; it woke him up from sleep and radiated to the mid back. On physical examination, his vital signs were stable and he had tenderness over the left flank. However, he developed hypotension, with mean arterial pressures dropping to 55  mm Hg and lactic acidosis requiring aggressive volume resuscitation.
Source: The American Journal of Medicine - January 30, 2017 Category: Journals (General) Authors: Aron Simkins, Abhishek Maiti, Sujith V. Cherian Tags: Clinical communication to the editor Source Type: research

The Reply
Arunachalam suggests that describing the reasons for readmissions might help in determining how to improve patient care. We agree, and this was our rationale for determining diagnosis syndromes for each patient.1 Overall, the increases in readmissions were observed across all diagnoses and accentuated for patients with stroke or delirium (Figure). This means that hospital admissions may also be influenced by other determinants of health.
Source: The American Journal of Medicine - February 17, 2017 Category: Journals (General) Authors: Christopher J. Yarnell, Steven Shadowitz, Donald A. Redelmeier Tags: AJM online Source Type: research