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Source: The American Journal of Medicine
Condition: Heart Disease
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Total 24 results found since Jan 2013.
Primary Medical Care Integrated with Healthy Eating and Healthy Moving is Essential to Reduce Chronic Kidney Disease Progression
Chronic kidney disease is among the few chronic diseases in the US with increasing prevalence 1, is the ninth leading cause of US mortality 2 and is increasing disability-adjusted life years lost 1, 3. Patients with chronic kidney disease contribute broadly to US mortality because they have increased risks for heart disease 4, cancer for those over age 65 years 5, and stroke 6 which represent, respectively, the first, second, and fifth causes of US mortality 2. Because patients with chronic kidney disease more likely die from these diseases before progressing to end-stage kidney disease 7, their deaths from these non-chron...
Source: The American Journal of Medicine - May 13, 2022 Category: General Medicine Authors: Donald E. Wesson, Vandana Mathur, Navdeep Tangri, Sarah Hamlett, David A. Bushinsky, L. Ebony Boulware Tags: Narrative Review Source Type: research
Microvascular dysfunction as a systemic disease: A review of the evidence
Microvascular dysfunction describes a varied set of conditions which includes vessel destruction, abnormal vasoreactivity, in situ thrombosis, and fibrosis which ultimately results in tissue damage and progressive organ failure. Microvascular dysfunction has a wide array of clinical presentations, ranging from ischemic heart disease to renal failure, stroke, blindness, pulmonary arterial hypertension, and dementia. An intriguing unifying hypothesis suggests that microvascular dysfunction of specific organs is an expression of a systemic illness that worsens with age and is accelerated by vascular risk factors.
Source: The American Journal of Medicine - April 22, 2022 Category: General Medicine Authors: Daniel S. Feuer, Eileen M. Handberg, Borna Mehrad, Janet Wei, C. Noel Bairey Merz, Carl J. Pepine, Ellen C. Keeley Tags: Review article Source Type: research
Non-Vitamin K Antagonists versus Warfarin in Patients with Atrial Fibrillation and Bioprosthetic Valves: a Systematic Review and Meta-Analysis
Patients with bioprosthetic heart valves and valve repair with concomitant atrial fibrillation are at an increased risk of thromboembolic events.1-5 Until recently, there was a paucity of randomized data to guide the optimal anticoagulation strategy in this patient population. In a prior meta-analysis of 4 randomized studies in patients with atrial fibrillation and valvular heart disease, excluding significant mitral stenosis and mechanical valves, there was a significant reduction in the risk of stroke or systemic embolism with non-vitamin K antagonist oral anticoagulants (NOACs) vs.
Source: The American Journal of Medicine - October 7, 2021 Category: General Medicine Authors: Rhanderson Cardoso, Caique M.P. Ternes, Gustavo B. Justino, Amanda Fernandes, Ana Vitoria Rocha, Leonardo Knijnik, Andre d'Avila, Renato D. Lopes Tags: Clinical Research Study Source Type: research
Cholesterol lowering and stroke: no longer room for pleiotropic effects of statins – confirmation from PCSK9 inhibitor studies
The relationship between cholesterol levels and stroke has been much less clear than between cholesterol levels and coronary heart disease. This is likely mostly due to the inadequate power of older studies and the low intensity of cholesterol-lowering interventions at that time available. Because a reduction in stroke has been, conversely, clearly observed in trials with statins, for long “pleiotropic” effects of such drugs, unrelated to cholesterol lowering, have been invoked. In a previous analysis of all randomized trials of cholesterol-lowering treatments reporting on stroke we had, however, reached the conclusion...
Source: The American Journal of Medicine - July 10, 2019 Category: General Medicine Authors: Tanya Salvatore, Riccardo Morganti, Roberto Marchioli, Raffaele De Caterina Tags: Clinical Research Study Source Type: research
Development and Preliminary Feasibility of an Automated Hypertension Self-Management System
Hypertension affects an estimated 30% of the world's adult population1 and is a primary source of all-cause death as well as stroke, heart disease and kidney failure. Despite significant improvements in hypertension diagnosis and treatment, over half of US adults with hypertension have uncontrolled blood pressure.2 Due to the recent changes to the ACC/AHA hypertension guidelines, specifically redefining stage 1 hypertension from 140-159/90-99 to 130-139/80-89 mm Hg and setting a goal of
Source: The American Journal of Medicine - May 25, 2018 Category: General Medicine Authors: Taya Irizarry, Matthew Allen, Brian P. Suffoletto, Julian Einhorn, Lora E. Burke, Thomas W. Kamarck, Bruce L. Rollman, Matthew F. Muldoon Tags: Clinical Research Study Source Type: research
Prescription of Statins to Women Poses New Clinical Challenges
In women and men, cardiovascular disease is and will remain the leading avoidable cause of premature death in the United States and is rapidly becoming so worldwide. (1) While many women fear breast cancer more than cardiovascular disease, 1 in 8 will develop and 1 in 25 will die from this disease whereas over 1 in 3 will die from coronary heart disease and 1 in 6 from stroke. (2)
Source: The American Journal of Medicine - April 18, 2018 Category: General Medicine Authors: Madeline Pung, Janet Robishaw, Marc A. Pfeffer, Charles H. Hennekens Tags: Commentary Source Type: research
Comparative Trends in Heart Disease, Stroke, and All-Cause Mortality in the United States and a Large Integrated Healthcare Delivery System
We examined whether differences in recent trends in heart disease, stroke, and total mortality exist in the United States and Kaiser Permanente Northern California (KPNC), a large integrated healthcare delivery system.
Source: The American Journal of Medicine - April 2, 2018 Category: General Medicine Authors: Stephen Sidney, Michael E. Sorel, Charles P. Quesenberry, Marc G. Jaffe, Matthew D. Solomon, Mai N. Nguyen-Huynh, Alan S. Go, Jamal S. Rana Tags: Clinical Research Study Source Type: research
Diagonal Earlobe Crease Frank's Sign - a Predictor of Cerebral Vascular Events
Frank's sign was first described in 1973 by an American physician (T. Frank). It is a diagonal crease in the earlobe which starts from the tragus to the edge of the auricle in an angle of 45 degrees in varying depths. Frank sign was described as a predictor of future coronary heart disease and peripheral vascular diseases. The aim of the study was to examine the association between Frank sign and the development of ischemic stroke.
Source: The American Journal of Medicine - April 28, 2017 Category: Journals (General) Authors: Saleh Nazzal, Basem Hijazi, Luai Khalila, Arnon Blum Tags: Clinical Research Study Source Type: research
Diagonal Earlobe Crease (Frank's Sign): A Predictor of Cerebral Vascular Events
Frank's sign was first described in 1973 by an American physician (Sonders T. Frank). It is a diagonal crease in the earlobe that starts from the tragus to the edge of the auricle in an angle of 45 ° in varying depths. Frank's sign was described as a predictor of future coronary heart disease and peripheral vascular diseases. The aim of the study was to examine the association between Frank's sign and the development of ischemic stroke.
Source: The American Journal of Medicine - April 28, 2017 Category: General Medicine Authors: Saleh Nazzal, Basem Hijazi, Luai Khalila, Arnon Blum Tags: Clinical research study Source Type: research
Salt, Tomato Soup, and the Hypocrisy of the American Heart Association
In no uncertain terms did the American Heart Association (AHA)1 condemn a recent study by Mente et al2 in The Lancet: “The findings in this study are not valid” … “a flawed study” … “you shouldn't use it to inform yourself about how you're going to eat” read some of the statements in the AHA's comment. The study in question suggested that not only will salt restriction not benef it most people, but it may actually be harmful if salt intake becomes too low. In only about 11% of the more than 100,000 study population, in patients who had high blood pressure, did salt restriction help to lower the risk of he...
Source: The American Journal of Medicine - November 20, 2016 Category: Journals (General) Authors: Franz H. Messerli, Stefano F. Rimoldi, Sripal Bangalore Tags: Commentary Source Type: research
Salt, Tomato Soup and Hypocrisy of the American Heart Association
In no uncertain terms did the American Heart Association (AHA)[1] condemn a recent study by Mente et al. in the Lancet[2] : “The findings in this study are not valid” … “a flawed study”…” you shouldn’t use it to inform yourself about how you’re going to eat” read some of the statements in the AHA’s comment. The study in question suggested that salt restriction will only not benefit most people but m ay actually be harmful if salt intake becomes too low. Only in about 11% of the more than 100 000 study population, in patients who had high blood pressure, did salt restriction help to lower the risk of h...
Source: The American Journal of Medicine - November 20, 2016 Category: Journals (General) Authors: Franz H. Messerli, Stefano. F. Rimoldi, Sripal Bangalore Tags: Commentary Source Type: research
Future of the Palliative Care Workforce: Preview to an Impending Crisis
The specialty of palliative care has experienced remarkable acceptance over the last decade, with teams present in 85% of medium/large hospitals in the United States.1 For many serious illnesses like cancer, advanced heart disease, stroke, and chronic obstructive pulmonary disease, routine integration of palliative care is considered standard of care.
Source: The American Journal of Medicine - September 25, 2016 Category: Journals (General) Authors: Arif H. Kamal, Janet H. Bull, Keith M. Swetz, Steven P. Wolf, Tait D. Shanafelt, Evan R. Myers Tags: Editorial Source Type: research
From Leptin, DEXA, and Beyond
Kahn and Bullard “recommend that waist circumference be added to BMI [body mass index] as a primary tool for assessing adiposity.”1 Suggesting “a need for alternative approaches to anthropometry”1 is necessary because BMI incorrectly classifies obesity by 39%.2 Many adults are obese by American Society of Ba riatric Physicians criteria of body fat: ≥25% for men and ≥30% for women.3 Normal-weight obese adults have increased mortality risk from diabetes, hypertension, heart disease, stroke, cancer, dyslipidemia, liver and gallbladder disease, sleep apnea and respiratory problems, and osteoarthritis.
Source: The American Journal of Medicine - July 28, 2016 Category: Journals (General) Authors: Eric R. Braverman Tags: AJM online Source Type: research
