• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Cholesterol lowering and stroke: no longer room for pleiotropic effects of statins – confirmation from PCSK9 inhibitor studies
The relationship between cholesterol levels and stroke has been much less clear than between cholesterol levels and coronary heart disease. This is likely mostly due to the inadequate power of older studies and the low intensity of cholesterol-lowering interventions at that time available. Because a reduction in stroke has been, conversely, clearly observed in trials with statins, for long “pleiotropic” effects of such drugs, unrelated to cholesterol lowering, have been invoked. In a previous analysis of all randomized trials of cholesterol-lowering treatments reporting on stroke we had, however, reached the conclusion...
Source: The American Journal of Medicine - July 10, 2019 Category: General Medicine Authors: Tanya Salvatore, Riccardo Morganti, Roberto Marchioli, Raffaele De Caterina Tags: Clinical Research Study Source Type: research

Prescription of Statins to Women Poses New Clinical Challenges
In women and men, cardiovascular disease is and will remain the leading avoidable cause of premature death in the United States and is rapidly becoming so worldwide. (1) While many women fear breast cancer more than cardiovascular disease, 1 in 8 will develop and 1 in 25 will die from this disease whereas over 1 in 3 will die from coronary heart disease and 1 in 6 from stroke. (2)
Source: The American Journal of Medicine - April 18, 2018 Category: General Medicine Authors: Madeline Pung, Janet Robishaw, Marc A. Pfeffer, Charles H. Hennekens Tags: Commentary Source Type: research

Diagonal Earlobe Crease Frank's Sign - a Predictor of Cerebral Vascular Events
Frank's sign was first described in 1973 by an American physician (T. Frank). It is a diagonal crease in the earlobe which starts from the tragus to the edge of the auricle in an angle of 45 degrees in varying depths. Frank sign was described as a predictor of future coronary heart disease and peripheral vascular diseases. The aim of the study was to examine the association between Frank sign and the development of ischemic stroke.
Source: The American Journal of Medicine - April 28, 2017 Category: Journals (General) Authors: Saleh Nazzal, Basem Hijazi, Luai Khalila, Arnon Blum Tags: Clinical Research Study Source Type: research

Diagonal Earlobe Crease (Frank's Sign): A Predictor of Cerebral Vascular Events
Frank's sign was first described in 1973 by an American physician (Sonders T. Frank). It is a diagonal crease in the earlobe that starts from the tragus to the edge of the auricle in an angle of 45 ° in varying depths. Frank's sign was described as a predictor of future coronary heart disease and peripheral vascular diseases. The aim of the study was to examine the association between Frank's sign and the development of ischemic stroke.
Source: The American Journal of Medicine - April 28, 2017 Category: General Medicine Authors: Saleh Nazzal, Basem Hijazi, Luai Khalila, Arnon Blum Tags: Clinical research study Source Type: research

Can the reduction percentage LDL-C or Attained LDL-C levels or both add incremental prognostic value?
The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease, has been well documented in several studies.1,2,3,4 The decrease in LDL-C levels leads to a significant reduction in the risk of atherosclerotic cardiovascular disease.5
Source: The American Journal of Medicine - November 13, 2015 Category: Journals (General) Authors: Leonardo Roever Tags: Editorial Source Type: research

Can the Reduction in Percent LDL Cholesterol or Attained LDL Cholesterol Levels or Both Add Incremental Prognostic Value?
The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease, has been well documented in several studies.1-4 The decrease in LDL-C levels leads to a significant reduction in the risk of atherosclerotic cardiovascular disease.5
Source: The American Journal of Medicine - November 13, 2015 Category: Journals (General) Authors: Leonardo Roever Tags: Editorial Source Type: research

The Diabetes Shared Care Program and Risks of Cardiovascular Events in Type 2 Diabetes
The Diabetes Shared Care Program (DSCP) is an integrated diabetes care model designed to increase the quality of diabetes care in Taiwan. The efficacy of this program is unknown. Therefore, we evaluated whether participating patients had reduced risks of cardiovascular events, including coronary heart disease, stroke, and all-cause mortality.
Source: The American Journal of Medicine - April 20, 2015 Category: Journals (General) Authors: Edy Kornelius, Jeng-Yuan Chiou, Yi-Sun Yang, Ying-Li Lu, Chiung-Huei Peng, Chien-Ning Huang Tags: Clinical Research Study Source Type: research

Cholesterol Management in Older Persons
Most atherosclerotic cardiovascular disease consists of coronary heart disease and stroke, and most atherosclerotic cardiovascular disease occurs in older persons. Randomized clinical trials with cholesterol-lowering drugs, notably statins, show reduced atherosclerotic cardiovascular disease events (1,2). Statins are indicated when atherosclerotic cardiovascular disease is present. They further reduce risk in primary prevention including older persons (1,2). But their indications in primary prevention are less well defined than for secondary prevention.
Source: The American Journal of Medicine - August 19, 2014 Category: Journals (General) Authors: Scott M. Grundy Source Type: research

Treat or Eat: Food Insecurity, Cost-related Medication Underuse, and Unmet Needs
Conclusions: Approximately 1 in 3 chronically ill NHIS participants are unable to afford food, medications, or both. WIC and public health insurance participation are associated with less food insecurity and cost-related medication underuse.
Source: The American Journal of Medicine - January 21, 2014 Category: Journals (General) Authors: Seth A. Berkowitz, Hilary K. Seligman, Niteesh K. Choudhry Tags: Clinical research studies Source Type: research