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Outcomes of Transcatheter Aortic Valve Replacement with Percutaneous Coronary Intervention versus Surgical Aortic Valve Replacement with Coronary Artery Bypass Grafting
We aimed to compare the outcomes of combined surgical aortic valve replacement (SAVR) with coronary artery bypass grafting (CABG) to concurrent transcatheter aortic valve replacement (TAVR) with percutaneous coronary intervention (PCI) in a large U.S. population sample. The National Inpatient Sample (NIS) was queried for all patients diagnosed with aortic valve stenosis who underwent SAVR with CABG or TAVR with PCI during the years 2016-2017. Study outcomes included all-cause in-hospital mortality, acute stroke, pacemaker insertion, vascular complications, major bleeding, acute kidney injury, sepsis, non-home discharge, le...
Source: The American Journal of Cardiology - September 25, 2020 Category: Cardiology Authors: Ashraf Abugroun, Mohammed Osman, Saria Awadalla, Lloyd Klein Source Type: research

Drug-eluting Stents Versus Bypass Surgery for Left Main Disease: An updated meta-analysis of randomized controlled trials with long-term follow-up
Debate is ongoing regarding the optimal mode of revascularization for patients with left main coronary artery disease (LMCAD). Longer-term follow-up from randomized trials has recently become available. We recently published a study-level meta-analysis that demonstrated similar mortality after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) when compared with coronary artery bypass grafting (CABG) 1. There were also no differences in cardiac death, stroke or myocardial infarction (MI), although there was a greater risk of unplanned revascularization after PCI.
Source: The American Journal of Cardiology - June 29, 2020 Category: Cardiology Authors: Yousif Ahmad, James P. Howard, Ahran D. Arnold, Ziad A. Ali, Darrel Francis, Jeffrey W. Moses, Martin B. Leon, Ajay J. Kirtane, Dimitri Karmpaliotis, Gregg W. Stone Source Type: research

Long-term outcomes with drug-eluting stents or coronary artery bypass surgery for unprotected left main coronary disease: A meta-analysis and trial sequential of randomized trials
Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) has emerged as an acceptable revascularization strategy for select patients with unprotected left main coronary disease (LMCA).1 The EXCEL trial showed no difference between DES and coronary artery bypass surgery (CABG) at 5 years for the composite of death, procedure and non-procedure related myocardial infarction (MI), or stroke,2 however; all-cause mortality was higher with DES at 5 years, which was a secondary end-point.
Source: The American Journal of Cardiology - April 13, 2020 Category: Cardiology Authors: Islam Y. Elgendy, Ahmed N. Mahmoud, Mohamed Gad, Akram Y. Elgendy, Deepak L. Bhatt Source Type: research

Pharmacoinvasive Strategy Versus Primary Percutaneous Coronary Intervention For ST-Segment Elevation Myocardial Infarction In Patients ≥ 70 Years of Age
This study compared efficacy and safety of PI with primary percutaneous coronary intervention (pPCI). Data from 2841 patients (mean age: 78.1±5.6 years, fema le: 36.1%) included in a prospective multicenter registry, and who underwent either PI (n=269) or pPCI (n=2572), were analyzed. The primary endpoint was in-hospital major adverse cardiovascular events (MACE) defined as the composite of all-cause mortality, non-fatal MI, stroke and definite stent thr ombosis.
Source: The American Journal of Cardiology - October 10, 2019 Category: Cardiology Authors: Vincent Auffret, Cl ément Laurin, Guillaume Leurent, Romain Didier, Emmanuelle Filippi, Jean-Philippe Hacot, Amer Zabalawi, Gilles Rouault, Djamel Saouli, Philippe Druelles, Isabelle Coudert, Bertrand Boulanger, Emilie Bot, Josiane Treuil, Marc Bedossa, Source Type: research

Relation of Preprocedural Hemoglobin Level to Outcomes After Percutaneous Coronary Intervention
This study assessed the impact of elevated Hb on major adverse cardiac and cerebrovascular event (MACCE) at 12 months, a composite of all-cause mortality, nonfatal myocardial infarction, and ischemic stroke after PCI. We pooled patient-level data from four Korean multicenter drug-eluting stent registries from 2010 to 2016.
Source: The American Journal of Cardiology - August 8, 2019 Category: Cardiology Authors: Byung Gyu Kim, Hyoeun Kim, Sung-Jin Hong, Chul-Min Ahn, Dong-Ho Shin, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Byeong-Keuk Kim, Byoung Kwon Lee Source Type: research

Dual Antiplatelet Therapy Cessation and Adverse Events after Drug-Eluting Stent Implantation in Patients at High Risk for Atherothrombosis. (From the PARIS Registry)
The impact of Dual Antiplatelet Therapy (DAPT) cessation after percutaneous coronary intervention with drug eluting stent implantation in patients at high atherothrombotic risk (ATR) remains unclear. We aimed to characterize the risk for adverse events, and its relationship with the mode of DAPT cessation in patients at atherothrombotic risk (HATR). Considering patients treated with drug-eluting stents among those enrolled in the PARIS registry, we defined subjects with prior myocardial infarction (MI), prior stroke or peripheral vascular disease at HATR, while patients without any of these conditions were classified as at...
Source: The American Journal of Cardiology - August 20, 2018 Category: Cardiology Authors: Sabato Sorrentino, Gennaro Giustino, Usman Baber, Samantha Sartori, David J. Cohen, Timothy D. Henry, Serdar Farhan, Madhav Sharma, Cono Ariti, George Dangas, Michael Gibson, Michela Faggioni, Mitchell W. Krucoff, Melissa Aquino, Jaya Chandrasekhar, David Source Type: research

Meta-Analysis of Comparison of 5-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Unprotected Left Main Coronary Artery in the Era of Drug-eluting Stents
Patients with unprotected left main coronary artery (ULMCA) disease are increasingly being treated with percutaneous coronary intervention (PCI) using drug-eluting stents (DES), but long-term outcomes comparing PCI with coronary artery bypass grafting (CABG) remain limited. We performed aggregate data meta-analyses of clinical outcomes (all-cause death, nonfatal myocardial infarction, stroke, repeat revascularization, cardiac death, and major adverse cardiac and cerebrovascular events) in studies comparing 5-year outcomes of PCI with DES versus CABG in patients with ULMCA disease.
Source: The American Journal of Cardiology - August 1, 2017 Category: Cardiology Authors: Mahin R. Khan, Waleed T. Kayani, Waqas Ahmad, Ravi S. Hira, Salim S. Virani, Ihab Hamzeh, Hani Jneid, Nasser Lakkis, Mahboob Alam Source Type: research

Meta-Analysis of Comparison of Five-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients with Unprotected Left Main Coronary Artery in the Era of Drug Eluting Stents
Patients with unprotected left main coronary artery (ULMCA) disease are increasingly being treated with percutaneous coronary intervention (PCI) using drug-eluting stents (DES), but long term outcomes comparing PCI with coronary artery bypass grafting (CABG) remain limited. We performed aggregate data meta-analyses of clinical outcomes [all cause death; non-fatal myocardial infarction (MI); stroke; repeat revascularization; cardiac death and major adverse cardiac and cerebrovascular events (MACCE)] in studies comparing 5 year outcomes of PCI with DES vs.
Source: The American Journal of Cardiology - August 1, 2017 Category: Cardiology Authors: Mahin R. Khan, Waleed T. Kayani, Waqas Ahmad, Ravi S. Hira, Salim S. Virani, Ihab Hamzeh, Hani Jneid, Nasser Lakkis, Mahboob Alam Source Type: research

Effect of Bleeding Risk on Type of Stent Used in Patients Presenting with Acute Coronary Syndrome
Patients at high bleeding risk (HBR) are at increased risk of bleeding following percutaneous coronary intervention (PCI) with drug-eluting stent (DES) due to the need for longer dual antiplatelet duration. We sought to evaluate the likelihood of receiving DES during PCI in HBR populations and to characterize DES utilization trends over time. Consecutive patients who underwent PCI from April 2003 to September 2015 were identified. HBR is defined as patients fulfilling one or more of the HBR criteria: age ≥75 years, anticoagulation use at discharge, history of stroke, cancer in previous 3 years, glucocorticoid use, hemoglobin (Hgb)
Source: The American Journal of Cardiology - July 24, 2017 Category: Cardiology Authors: M. Chadi Alraies, Sang Yeub Lee, Michael J. Lipinski, Kyle Buchanan, Arie Steinvil, Toby Rogers, Edward Koifman, Jiaxiang Gai, Rebecca Torguson, Itsik Ben-Dor, Lowell F. Satler, Augusto D. Pichard, Ron Waksman Source Type: research

Comparison of Outcome of Coronary Artery Bypass Grafting versus Drug-Eluting Stent Implantation for Non-ST-Elevation Acute Coronary Syndrome
There is limited data comparing effectiveness of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) with drug-eluting stents (DES) in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). We compared the long-term outcomes of the two revascularization strategies in 1,246 patients presented with NSTE-ACS for left main or multivessel coronary artery disease (CAD). Data were pooled from the BEST, PRECOMBAT, and SYNTAX trials. The primary outcome was a composite of death from any causes, myocardial infarction, or stroke.
Source: The American Journal of Cardiology - May 10, 2017 Category: Cardiology Authors: Mineok Chang, Cheol Whan Lee, Jung-Min Ahn, Rafael Cavalcante, Yohei Sotomi, Yoshinobu Onuma, Minkyu Han, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Patrick W. Serruys, Seung-Jung Park Source Type: research

Meta-Analysis of Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting in Left Main Coronary Arterial Disease
Despite the increase in use of percutaneous coronary intervention (PCI) in left main (LM) coronary disease, its efficacy compared with coronary artery bypass grafting (CABG) is unclear. We performed a meta-analysis of randomized controlled trials to assess the optimal revascularization strategy. Our search yielded 8 studies reporting relevant outcomes which were pooled using the inverse-variance method, and the hazard ratio (HR) was calculated. The primary outcome was all-cause mortality, myocardial infarction (MI), or stroke (MACE), and the secondary outcome was death/MI/stroke/repeat revascularization (expanded MACE).
Source: The American Journal of Cardiology - March 28, 2017 Category: Cardiology Authors: Abdur R. Khan, Harsh Golwala, Avnish Tripathi, Haris Riaz, Arnav Kumar, Michael P. Flaherty, Deepak L. Bhatt Source Type: research

Triggering of Stroke or Atrial Fibrillation by Percutaneous Coronary Intervention
I have read the article entitled “Percutaneous Coronary Intervention as a Trigger for Stroke” by Varmdal et al. 1 with great interest, recently published in journal. Their estimates indicated a substantially increased risk of ischemic stroke during the first 2 days after percutaneous coronary intervention (PCI). Relative risk t hen decreased gradually but stayed elevated for 8 weeks. Increased awareness of this vulnerable period after PCI in clinicians and patients could contribute to earlier detection and treatment for patients suffering a postprocedural stroke 1.
Source: The American Journal of Cardiology - January 2, 2017 Category: Cardiology Authors: Levent Cerit Source Type: research

Percutaneous Coronary Intervention as a Trigger for Stroke
This study aimed to quantify the transient change in risk of stroke for up to 12 weeks after PCI. We applied the case-crossover method, using data from the Norwegian Patient Register on all hospitalizations in Norway in the period of 2008 through 2014. The relative risk (RR) of ischemic stroke was highest during the first two days after PCI (RR 17.5, 95% CI 4.2-72.8), and decreased gradually during the following weeks.
Source: The American Journal of Cardiology - September 28, 2016 Category: Cardiology Authors: Torunn Varmdal, Imre Janszky, Inger Johanne Bakken, Hanne Ellekj ær, Hild Fjærtoft, Siri Eldevik Håberg, Kaare Harald Bønaa Source Type: research

Evaluation of 5 Prognostic Scores for Prediction of Stroke, Thromboembolic and Coronary Events, All-Cause Mortality, and Major Adverse Cardiac Events in Patients With Atrial Fibrillation and Coronary Stenting
Management of antithrombotic therapy in patients with atrial fibrillation (AF) and coronary stenting remains challenging, and there is a need for efficient tools to predict their risk of different types of cardiovascular events and death. Several scores exist such as the CHA2DS2-VASc score, the Global Registry of Acute Coronary Events (GRACE) score, the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score, the Anatomical and Clinical Syntax II Score and the Reduction of Atherothrombosis for Continued Health score.
Source: The American Journal of Cardiology - June 13, 2016 Category: Cardiology Authors: Laurent Fauchier, Coralie Lecoq, Yann Ancedy, Karim Stamboul, Christophe Saint Etienne, Fabrice Ivanes, Denis Angoulvant, Dominique Babuty, Yves Cottin, Gregory Y.H. Lip Tags: Arrhythmias and Conduction Source Type: research

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