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Comparison of Dabigatran Versus Warfarin Treatment for Prevention of New Cerebral Lesions in Valvular Atrial Fibrillation
Warfarin is the standard anticoagulation therapy for valvular atrial fibrillation (AF); however, new oral anticoagulants have emerged as an alternative. We compared the efficacy and safety of dabigatran with conventional treatment in AF associated with left-sided valvular heart disease (VHD), including mitral stenosis (MS). Patients with AF and left-sided VHD were randomly assigned to receive dabigatran or conventional treatment. The primary end point was the occurrence of clinical stroke or a new brain lesion (silent brain infarct and microbleed) on 1-year follow-up brain magnetic resonance imaging.
Source: The American Journal of Cardiology - May 9, 2022 Category: Cardiology Authors: Min Soo Cho, Minsu Kim, Seung-ah Lee, Sahmin Lee, Dae-Hee Kim, Jun Kim, Jong-Min Song, Gi-Byoung Nam, Sang Joon Kim, Duk-Hyun Kang, Kee-Joon Choi Source Type: research

Quantitative Evaluation of Mitral Regurgitation Secondary to Mitral Valve Prolapse by Magnetic Resonance Imaging and Echocardiography
The present prospective study was designed to evaluate the accuracy of quantitative assessment of mitral regurgitant fraction (MRF) by echocardiography and cardiac magnetic resonance imaging (cMRI) in the modern era using as reference method the blinded multi-parametric integrative assessment of mitral regurgitation (MR) severity. 2D- and 3D- MRF by echocardiography (2D Echo MRF and 3D Echo MRF) were obtained by measuring the difference in left ventricular (LV) total stroke volume (obtained from either 2D or 3D acquisition) and aortic forward stroke volume normalized to LV total stroke volume.
Source: The American Journal of Cardiology - August 14, 2015 Category: Cardiology Authors: Caroline Le Goffic, Manuel Toledano, Pierre-Vladimir Ennezat, Camille Binda, Anne-Laure Castel, François Delelis, Pierre Graux, Christophe Tribouilloy, Sylvestre Maréchaux Source Type: research

Effect of Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension on Stroke Volume Response to Exercise
In pulmonary hypertension, exercise is limited by an impaired right ventricular (RV) stroke volume response. We hypothesized that improvement in exercise capacity after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) is paralleled by an improved RV stroke volume response. We studied the extent of PEA-induced restoration of RV stroke volume index (SVI) response to exercise using cardiac magnetic resonance imaging (cMRI). Patients with CTEPH (n = 18) and 7 healthy volunteers were included. Cardiopulmonary exercise testing and cMRI were performed before and 1 year after PEA. For cMRI ...
Source: The American Journal of Cardiology - April 21, 2014 Category: Cardiology Authors: Sulaiman Surie, Mart N. van der Plas, J. Tim Marcus, Taco Kind, Jaap J. Kloek, Anton Vonk-Noordegraaf, Paul Bresser Tags: Miscellaneous Source Type: research

Meta-Analysis of Global Left Ventricular Function Comparing Multidetector Computed Tomography With Cardiac Magnetic Resonance Imaging
We compare the diagnostic accuracy of multidetector row computed tomography (MDCT) to cardiac magnetic resonance imaging (CMR) for evaluating global left ventricular function. We systematically searched PubMed, CINAHL, Cochrane CENTRAL, Scopus, and the Web of Science databases for studies published between 1966 to January 2013 that compared left ventricle (LV) volumes, ejection fraction (EF) and LV mass measured by MDCT and CMR. We performed meta-analyses and used random-effects model with inverse variance weighting test to determine the overall bias and limits of agreement of LV end-diastolic volume, end-systolic volume, ...
Source: The American Journal of Cardiology - November 27, 2013 Category: Cardiology Authors: Abhishek Sharma, Andrew J. Einstein, Ajay Vallakati, Armin Arbab-Zadeh, Debabrata Mukherjee, Edgar Lichstein Tags: Methods Source Type: research

Prevalence of and Risk Factors for Silent Ischemic Stroke in Patients With Atrial Fibrillation as Determined by Brain Magnetic Resonance Imaging
Varied silent ischemic stroke (SS) prevalence occurs in patients with atrial fibrillation (AF). Stroke history is worth 2 points in the CHADS2 scoring system. An unknown proportion of patients with AF with a CHADS2 score of 0 or 1 have been undertreated for stroke prevention. We investigated SS risk factors using magnetic resonance imaging and estimated SS impact on clinical outcomes in patients with AF. We analyzed a total of 1,200 patients (400 with AF and 800 with sinus rhythm) who had brain magnetic resonance imaging performed for routine health checkups. Clinical outcomes including symptomatic stroke, dementia, and co...
Source: The American Journal of Cardiology - November 25, 2013 Category: Cardiology Authors: Myung-jin Cha, Hyo Eun Park, Min-ho Lee, Youngjin Cho, Eue-keun Choi, Seil Oh Tags: Arrhythmias and Conduction Disturbances Source Type: research

Accuracy and Feasibility of Simplified Doppler-Based Left Ventricular Ejection Fraction
Calculation of left ventricular (LV) ejection fraction (EF) by Doppler stroke volume and end-diastolic volume (EDV) derived from LV diastolic diameter (LVIDD) could be reliable and feasible in clinical practice. In subjects with a wide range of LV volumes and EFs, magnetic resonance imaging (MRI) was used to evaluate the accuracy of common formulas (Teichholz and Z method) to estimate EDV from LVIDD (EDVTeich; EDVZ) versus volumetric EDV. The accuracy of simplified Doppler-EF was tested in a separate study sample versus real-time 3-dimensional (RT3D) echocardiography and versus bidimensional Simpson's method. A new equatio...
Source: The American Journal of Cardiology - June 10, 2013 Category: Cardiology Authors: Vittorio Palmieri, Fiorenzo Manganelli, Cesare Russo, Biagio Gagliardi, Salvatore Pezzullo, Giuliano Gagliardi, Giuseppe Rosato, Carmelo Lombardi Tags: Methods Source Type: research

Relation of Subclinical Coronary Artery Atherosclerosis to Cerebral White Matter Disease in Healthy Subjects From Families With Early-Onset Coronary Artery Disease
White matter disease (WMD) of the brain is associated with incident stroke. Similarly, subclinical calcified coronary artery plaque has been associated with incident coronary artery disease (CAD) events. Although atherogenesis in both vascular beds may share some common mechanisms, the extent to which subclinical CAD is associated with WMD across age ranges in subjects with a family history of early-onset CAD remains unknown. We screened 405 apparently healthy participants in the Genetic Study of Atherosclerotic Risk for CAD risk factors and for the presence of noncalcified and calcified coronary plaque using dual-source m...
Source: The American Journal of Cardiology - June 5, 2013 Category: Cardiology Authors: Brian G. Kral, Paul Nyquist, Dhananjay Vaidya, David Yousem, Lisa R. Yanek, Elliot K. Fishman, Lewis C. Becker, Diane M. Becker Tags: Coronary Artery Disease Source Type: research

Importance of Three-Dimensional Geometric Analysis in the Assessment of the Athlete's Heart
How the left ventricle remodels in response to a high-volume stimulus is important in evaluating the endurance athlete's heart. Marathoners and patients with isolated, moderate chronic compensated mitral regurgitation (MR) represent physiologic and pathologic forms of eccentric left ventricular (LV) remodeling in response to intermittent and chronic volume overload, respectively. Thus, in this study, magnetic resonance imaging with tissue tagging and 3-dimensional data analysis at rest were performed in 19 marathoners (mean age 39 ± 10 years, 47% women), 17 patients with isolated MR without coronary artery disease or medi...
Source: The American Journal of Cardiology - January 21, 2013 Category: Cardiology Authors: Chun G. Schiros, Mustafa I. Ahmed, Thriveni Sanagala, Wei Zha, David C. McGiffin, Marcas M. Bamman, Himanshu Gupta, Steven G. Lloyd, Thomas S. Denney, Louis J. Dell'Italia Tags: Miscellaneous Source Type: research