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Development of new atherosclerotic plaque in hypertensive patients: an observational registry study from the Campania-Salute network
Background and purpose: Carotid atherosclerotic plaques (CAPs) can develop despite appropriate antihypertensive therapy. In this observational study, we assessed characteristics associated with risk of incident CAP in a large hypertensive registry. Methods: We evaluated 2143 hypertensive patients without evidence of CAP. Incident CAP was censored at the time of the first ultrasound control in which CAP was detected. CAP was defined according to European Society of Hypertension/European Society of Cardiology guidelines. Results: At a median follow-up period of 56.6 months, about one-third of patients (32%; N = 688) exhi...
Source: Journal of Hypertension - November 12, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Blood vessels Source Type: research

Carotid intima–media thickness, but not chronic kidney disease independently associates with noncardiac arterial vascular events in South Africa
Aim: Although chronic kidney disease (CKD) as determined from estimated glomerular filtration rate (eGFR) is recommended for risk prediction by current hypertension guidelines, the equations to derive eGFR may not perform well in black Africans. We compared whether across the adult lifespan, eGFR or CKD are as closely associated with noncardiac arterial vascular events, as carotid intima–media thickness (IMT), in Africa. Methods: In 1152 black South Africans [480 with noncardiac arterial events (294 with critical lower limb ischemia, 186 with stroke) of which 37% were premature] and 672 age, sex and ethnicity-matche...
Source: Journal of Hypertension - March 1, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research