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Source: Journal of Hypertension

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Total 283 results found since Jan 2013.

Compensatory functional reorganization may precede hypertension-related brain damage and cognitive decline: a functional magnetic resonance imaging study
This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale. Results: No intergroup differences were found in regards to the severity of white matter lesions (Mann–Whitney U test = 150.5, P > 0.1), nor from the task performance in the scanner (t(35) = 0.2, P > 0.1). However, brain activation patterns between patients and controls varied. Hypertensive patients involved significantly more cerebral areas during the processing, regardless of the task difficulty. Differences were found in 26 diverse regions of both pri...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research

Physical activity and cognitive function among older adults with hypertension
Objective: We evaluated the specific association between physical activity and cognitive function among a national sample of the broader US adult population with evidence of systemic hypertension. Methods: Data from the 1999–2002 National Health and Nutrition Examination Survey were used to identify 1554 older adults, aged 60–85 years, with evidence of hypertension. The Digit Symbol Substitution Test (DSST) was used to assess cognitive function tasks of pairing and free recall among participants. Participants were asked open-ended questions about participation in leisure-time physical activity over the past 30 days. F...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research

Side effects and tolerability of combination blood pressure lowering according to blood pressure levels: an analysis of the PROGRESS and ADVANCE trials
Conclusion: Compared with those with baseline SBP 140–159 mmHg, side effects of dual combination BPL are essentially the same for people with SBP 130–139 mmHg and only modestly increased among patients with SBP 120–129 mmHg. During long-term therapy, side effects sufficient to stop treatment that are treatment related (i.e. occur in excess of rates seen with placebo) occur at less than 0.5%/year in patients with baseline SBP 120–139 mmHg. These results have important implications in assessing the likely balance of benefits and side effects of BPL with combination therapy among those with SBP 120–139 mmHg.
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Normal cerebral vascular pulsations in humans: changes with age and implications for microvascular disease
Background: Cerebral syndromes in older humans, secondary stroke in younger persons following trauma, and sickle cell anaemia in children, are linked by unexplained microvascular damage and high cerebral pressure or flow pulsations. The aim of this study was to characterize age-related pressure and flow waveforms patterns entering the brain, to explain these in terms of disturbed physiological function, and to consider clinical implications. Method: Blood flow velocity waves were measured in four cerebral vascular territories by transcranial Doppler of 1020 apparently normal patients (497 men, 21–78 years). Central pres...
Source: Journal of Hypertension - September 28, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Blood vessels Source Type: research

Diurnal variation and repeatability of arterial stiffness and cardiac output measurements in the third trimester of uncomplicated pregnancy
Aim: To investigate same day repeated measures and diurnal variation of arterial stiffness, cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) during the third trimester of normal pregnancy. Methodology: Pulse wave velocity (PWV) and augmentation index (AIx) were recorded using the Arteriograph, while CO, SV and TPR were recorded using noninvasive cardiac output monitoring. The measurements were obtained in the third trimester of pregnancy from 21 healthy pregnant women at four time points (morning, afternoon, evening and midnight) over a 24-h period. Triplicate measurements of 67 women were obt...
Source: Journal of Hypertension - November 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Blood vessels Source Type: research

Early life exposure to Chinese famine modifies the association between hypertension and cardiovascular disease
Objective: Studies have shown that famine exposure during early life may increase the risk of cardiovascular disease (CVD), hypertension, and diabetes during adulthood. We aimed to assess whether exposure to the Chinese famine (1959–1961) modifies the association between hypertension and CVD. Methods: We investigated data of 5772 adults born between 1954 and 1964 from the China Health and Retirement Longitudinal Study. CVD was based on self-reported doctor's diagnosis of heart problems (heart attack, coronary heart disease, angina, congestive heart failure, or other heart problems) and stroke. Results: Overall, h...
Source: Journal of Hypertension - November 30, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Apparent resistant hypertension and the risk of vascular events and mortality in patients with manifest vascular disease
Conclusion: In hypertensive patients with clinically manifest vascular disease, presence of controlled and uncontrolled aRH is related to an increased risk of cardiovascular mortality and all-cause mortality.
Source: Journal of Hypertension - November 30, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Resistant hypertension Source Type: research

Cardiovascular risk and blood pressure lowering treatment among elderly individuals: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan
Conclusion: Although impact on BP was more evident among young-old than old-old individuals, clinicians who prescribe antihypertensive medication to elderly patients should consider that such patients require further monitoring.
Source: Journal of Hypertension - December 20, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Effect of total, domain-specific, and intensity-specific physical activity on all-cause and cardiovascular mortality among hypertensive adults in China
Objectives: We aimed to prospectively examine the associations of total, domain-specific, and intensity-specific physical activity with all-cause and cardiovascular mortality among Chinese hypertensive adults. Methods: We performed a prospective cohort study in 150 391 hypertensive participants aged 30–79 years from the China Kadoorie Biobank study of 512 891 participants recruited from 10 diverse areas across China during 2004–2008. Participants with heart disease, stroke, chronic obstructive pulmonary disease, and cancer at baseline were excluded. Results: During 1069 863 person-years of follow-up (medi...
Source: Journal of Hypertension - March 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Lifestyle Source Type: research

Gender, blood pressure, and cardiovascular and renal outcomes in adults with hypertension from the Systolic Blood Pressure Intervention Trial
Conclusion: In adults with hypertension but not with diabetes, treatment to a systolic blood pressure goal of less than 120 mmHg, compared with a goal of less than 140 mmHg, resulted in no heterogeneity of effect between men and women on cardiovascular or renal outcomes, or on rates of serious adverse events. ClinicalTrials.gov number, NCT01206062.
Source: Journal of Hypertension - March 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Target home morning SBP be below 125 mmHg in type 2 diabetes patients
Background: It is not established to what extent self-monitoring of home BP be lowered in patients with type 2 diabetes. We tested the hypothesis that the appropriate home morning SBP cutoff value is 125 mmHg in our stratification of cardiovascular risk in type 2 diabetes. Method: Clinic and home BP monitoring were performed in 4308 individuals (1057 people with diabetes and 3251, nondiabetes), and we tested two cutoff values of home morning SBP (MSBP): 135 and 125 mmHg. Multivariable Cox regression analyses adjusting for age, sex, body mass index, history of cardiovascular events, presence of chronic kidney disea...
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: BP measurement Source Type: research

High SBP trajectories are associated with risk of all-cause death in general Chinese population
Conclusion: High SBP trajectories are independent risk factors for all-cause death. Our findings suggest increasing SBP trajectories within the currently designated ‘normal’ range may still increase risk of all-cause death.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity part A mechanisms of obesity induced hypertension, diabetes and dyslipidemia and practice guidelines for treatment
Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key ro...
Source: Journal of Hypertension - May 31, 2018 Category: Cardiology Tags: Consensus Documents Source Type: research

Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity part B obesity-induced cardiovascular disease, early prevention strategies and future research directions
Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke, which are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications.
Source: Journal of Hypertension - May 31, 2018 Category: Cardiology Tags: Consensus Documents Source Type: research