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Hospital participation in clinical trials for patients with acute myocardial infarction: Results from the National Cardiovascular Data Registry
ConclusionsHospitals are becoming less likely to engage in clinical trials for patients with MI. Patients admitted to hospitals that participated in clinical trials more often received guideline-adherent care and had better long-term outcomes.
Source: American Heart Journal - May 26, 2019 Category: Cardiology Source Type: research

Lessons learned about stress and the heart after major earthquakes
Publication date: Available online 6 June 2019Source: American Heart JournalAuthor(s): Robert A. KlonerAbstractThere is evidence that certain stressors can trigger cardiovascular events. Several studies have now demonstrated an increase in major adverse cardiac events associated with natural disasters such as an earthquake. The purpose of this paper is to review the literature on earthquakes and cardiovascular events. Reports from 13 major quakes were reported. Earthquakes have been associated with a number of cardiac events including sudden cardiac death, fatal myocardial infarction (MI), myocardial infarction, stress car...
Source: American Heart Journal - June 6, 2019 Category: Cardiology Source Type: research

Premorbid levels of high-sensitivity cardiac troponin T and natriuretic peptide and prognosis after incident myocardial infarction
ConclusionsPremorbid levels of hs-cTnT and NT-proBNP assessed on average six years prior to incident MI were associated with adverse outcomes after incident MI. These results further highlight the importance of cardiac health at an earlier stage of life.
Source: American Heart Journal - July 13, 2019 Category: Cardiology Source Type: research

Incidence and predictors of atrial fibrillation episodes as detected by implantable loop recorder in patients at risk From the LOOP study
ConclusionA considerable burden of previously unknown AF was detected when long-term monitoring was applied in at-risk patients. Biomarkers were associated with AF incidence and improved prediction of long AF episodes.
Source: American Heart Journal - October 21, 2019 Category: Cardiology Source Type: research

Associations between beta-blocker therapy and cardiovascular outcomes in patients with diabetes and established cardiovascular disease
ConclusionsIn this observational analysis of T2D and ASCVD, baseline beta-blocker use was not associated with risks for severe hypoglycemia yet also was not associated with CV risk reduction over 3 years of follow-up, supporting a randomized examination of chronic beta-blocker therapy in this patient population. (TECOS ClinicalTrials.gov number, NCT00790205).
Source: American Heart Journal - October 21, 2019 Category: Cardiology Source Type: research

Sex-specific Cardiac Phenotype and Clinical Outcomes in Patients with Hypertrophic Cardiomyopathy
ConclusionsOur results suggest that sex-specific differences in LV geometry, hyper-contractility and diastolic function, not greater degree of LV myopathy, contribute to a higher, age-independent risk of diastolic HF in women with HCM.Graphical abstract
Source: American Heart Journal - October 21, 2019 Category: Cardiology Source Type: research

Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation
ConclusionsIn AF patients, there is underuse of GDT for non-AF comorbidities. The association between GDT use and outcomes was strongest in heart failure and obstructive sleep apnea patients where use of GDT was associated with lower mortality and less AF progression.
Source: American Heart Journal - November 9, 2019 Category: Cardiology Source Type: research

Associations between β-blocker therapy and cardiovascular outcomes in patients with diabetes and established cardiovascular disease
ConclusionsIn this observational analysis of T2D and ASCVD, baseline β-blocker use was not associated with risks for severe hypoglycemia yet also was not associated with CV risk reduction over 3 years of follow-up, supporting a randomized examination of chronic β-blocker therapy in this patient population. (TECOS ClinicalTrials.gov number, NCT00790205).
Source: American Heart Journal - November 11, 2019 Category: Cardiology Source Type: research

Transcatheter InterAtrial shunt device for the treatment of heart failure: Rationale and Design of the Pivotal Randomized Trial to REDUCE elevated left atrial pressure in patients with heart failure II (REDUCE LAP-HF II)
ConclusionsREDUCE LAP-HF II is designed to evaluate the clinical efficacy of the IASD device in patients with symptomatic HF with elevated LA pressure and LVEF≥40%.
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

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