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Thromboembolism after WATCHMANTM in a clopidogrel non ‐responder: A case for concern?
Abstract Atrial fibrillation (AF) is associated with an increased risk of stroke and thromboembolism (TE). The WATCHMANTM left atrial appendage (LAA) closure device is indicated to reduce the risk of TE from the LAA in patients with non‐valvular AF. Here, we present a case of a patient with device‐related thrombus who suffered a TE event two months after WATCHMANTM LAA closure and two weeks after switching from aspirin plus warfarin to aspirin plus clopidogrel therapy. Laboratory investigation identified the patient to be hypercoagulable and to be a non‐responder to clopidogrel therapy. We discuss the potential role ...
Source: Catheterization and Cardiovascular Interventions - November 11, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Ganesh Venkataraman, Kevin P. Bliden, Udaya S. Tantry, Paul A. Gurbel Tags: VALVULAR AND STRUCTURAL HEART DISEASES Source Type: research

Left atrial appendage closure: First in man with the 4th generation watchman device
ConclusionsLAA closure with the 4th generation WATCHMAN device is feasible and safe. New technical features may contribute to a better performance of the occluder, particularly regarding the risk of pericardial effusions. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - September 10, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Jakob Ledwoch, Jennifer Franke, Maik Gonzaga, Stefan Bertog, Annkathrin Braut, Ilona Hofmann, Laura Vaskelyte, Sameer Gafoor, Vivek Reddy, Horst Sievert Tags: Valvular and Structural Heart Diseases Source Type: research

Evaluation of the efficacy and safety of dual antiplatelet therapy with or without warfarin in patients with a clinical indication for DAPT and chronic anticoagulation: A meta‐analysis of observational studies
Conclusions: All‐cause mortality appears similar in patients treated with TT or DAPT although TT was associated with higher rates of major bleeding and a lower risk for ischemic stroke. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - September 10, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Chirag Bavishi, Anna Koulova, Sripal Bangalore, Ashwin Sawant, Saurav Chatterjee, Sameer Ather, Jose Valencia, Nikolaus Sarafoff, Andrea Rubboli, Juhani K. Airaksinen, Gregory Y. H. Lip, Jacqueline E. Tamis‐Holland Tags: Coronary Artery Disease Source Type: research

Safety of percutaneous left atrial appendage closure with the amplatzer cardiac plug in patients with atrial fibrillation and contraindications to anticoagulation
Conclusion: Percutaneous LAA closure with the ACP in patients with contraindications to oral anticoagulation is safe. The stroke and bleeding risk after percutaneous LAA closure is lower than predicted by conventional risk scores. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - December 11, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Jens Wiebe, Stefan Bertog, Jennifer Franke, Olga Wettstein, Katharina Lehn, Ilona Hofmann, Laura Vaskelyte, Horst Sievert Tags: Original Study Source Type: research

Successful closure of residual leak following lariat procedure in a patient with high risk of stroke and hemorrhage
Percutaneous left atrial appendage suture ligation with the LARIAT® device (Sentre HEART, Redwood City, CA) was successfully performed on an 84‐year‐old woman with non‐valvular atrial fibrillation who developed intracranial hemorrhage on warfarin. However, a large gap developed at follow‐up precluding warfarin cessation. To the best of our knowledge, this case report represents the first description of the use of a Gore® Helex® Septal Occluder (W. L. Gore and Associates, Newark, Delaware) as a novel approach to close a gap following percutaneous LAA suture ligation. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - November 9, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wen‐Loong Yeow, Takashi Matsumoto, Saibal Kar Tags: Valvular and Structural Heart Diseases Source Type: research

Successful closure of residual leak following LARIAT procedure in a patient with high risk of stroke and hemorrhage.
Abstract Percutaneous left atrial appendage suture ligation with the LARIAT® device (Sentre HEART, Redwood City, California) was successfully performed on an 84‐year‐old woman with non‐valvular atrial fibrillation who developed intracranial hemorrhage on warfarin. However, a large gap developed at follow‐up precluding warfarin cessation. To the best of our knowledge, this case report represents the first description of the use of a Gore® Helex® Septal Occluder (W. L. Gore and Associates, Newark, Delaware) as a novel Removed: and effectiveapproach to close a gap following percutaneous LAA suture ligation. © 2013...
Source: Catheterization and Cardiovascular Interventions - October 2, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wen‐Loong Yeow, Takashi Matsumoto, Saibal Kar Tags: Research Article Source Type: research