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Relationship between ‘on-treatment platelet reactivity’, shear stress, and micro-embolic signals in asymptomatic and symptomatic carotid stenosis
DiscussionRecently symptomatic moderate –severe carotid stenosis patients had a lower prevalence of aspirin–HTPR than their asymptomatic counterparts on the PFA-100®, likely related to higher aspirin doses. The prevalence of antiplatelet –HTPR was positively influenced by higher shear stress levels, but not MES status.
Source: Journal of Neurology - October 11, 2019 Category: Neurology Source Type: research

Efficacy of STA –MCA bypass surgery in moyamoya angiopathy: long-term follow-up of the Caucasian Krupp Hospital cohort with 81 procedures
ConclusionDirect STA –MCA bypass is an effective therapy in Caucasian patients with hemodynamically compromised MA.
Source: Journal of Neurology - October 1, 2018 Category: Neurology Source Type: research

Vertebral artery hypoplasia: an innocent lamb or a disguise?
ConclusionsAccording to our study, VAH identifies patients at higher risk of posterior circulation stroke, and higher frequency of contralateral vertebral artery stenosis and basilar artery stenosis.
Source: Journal of Neurology - August 16, 2018 Category: Neurology Source Type: research

Increased platelet count and reticulated platelets in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic signal-negative patient subgroups: results from the HaEmostasis In carotid STenosis (HEIST) study
DiscussionThe combination of increased platelet counts and a shift towards production of an increased population of larger, young, reticulated platelets could contribute to a higher risk of first or recurrent cerebrovascular events in recently symptomatic versus asymptomatic carotid stenosis, including those who are MES −ve.
Source: Journal of Neurology - February 23, 2018 Category: Neurology Source Type: research

Effects of ezetimibe and anticoagulant combined therapy on progressing stroke: a randomized, placebo-controlled study
AbstractDespite the high prevalence of progressing stroke in patients with acute stroke, preventative treatments are still the unmet needs for those patients. The aim of this study was to evaluate, prospectively, the efficacy and safety of ezetimibe in the prevention of acute progressing stroke and thereby the improvement of patient outcome. A total of 423 patients (267 men and 156 women with a mean age of 65.2  years) were randomly assigned to receive ezetimibe (10 mg daily oral administration,n = 209) or placebo (n = 214) for 14 consecutive days. Analytical procedures performed at baseline (i.e., day 1) and 14 day...
Source: Journal of Neurology - September 14, 2016 Category: Neurology Source Type: research