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Data lake-driven analytics identify nocturnal non-dipping of heart rate as predictor of unfavorable stroke outcome at discharge
ConclusionsOur data suggest that a lack of circadian HR modulation, specifically nocturnal non-dipping, is associated with short-term unfavorable functional outcome after stroke, and that including HR into machine learning-based prediction models may lead to improved stroke outcome prediction.
Source: Journal of Neurology - April 20, 2023 Category: Neurology Source Type: research

Patterns of acute ischemic stroke and intracranial hemorrhage in patients with COVID-19
In this study, we sought to investigate associations between neuroimaging findings with clinical, demographic, blood and cerebrospinal fluid (CSF) parameters, pre-existing conditions and the severity of acute COVID-19.Materials and methodsRetrospective multicenter data retrieval from 10 university medical centers in Germany, Switzerland and Austria between February 2020 and September 2021. We included patients with COVID-19, acute neurological symptoms and cranial imaging. We collected demographics, neurological symptoms, COVID-19 severity, results of cranial imaging, blood and CSF parameters during the hospital stay.Resul...
Source: Journal of Neurology - February 23, 2023 Category: Neurology Source Type: research

Endovascular stroke treatment in orally anticoagulated patients: an analysis from the German Stroke Registry-Endovascular Treatment
ConclusionsET can be performed safely and successfully in LVO stroke patients treated with OAC.Clinical trial registration-URLhttp://www.clinicaltrials.gov. Unique identifier: NCT03356392.
Source: Journal of Neurology - December 29, 2020 Category: Neurology Source Type: research

A review of mobile stroke units
AbstractPurpose of reviewMobile stroke units (MSUs) for prehospital treatment and management of patients with acute stroke have been developed more than a decade ago and is currently spreading worldwide. This review discusses the history of MSU and current operations and research.Recent findingsMultiple studies have shown that MSU can significantly reduce treatment time with a tenfold increase of patients treated within the first 60  min of symptom onset. Recent preliminary results from the Berlin Prehospital or Usual Delivery of Acute Stroke Care trial (B-PROUD) showed a positive shift in modified Rankin Scale (mRS) scor...
Source: Journal of Neurology - May 17, 2020 Category: Neurology Source Type: research

Impact of comorbidities and co-medication on disease onset and progression in a large German ALS patient group
ConclusionsOur results suggest stroke, lower BMI, and regular physical activity as risk factors for ALS. Strokes could be a possible trigger of the pathogenetic pathway of ALS and the lower BMI with consecutively lower rate of hyperlipidemia supports the hypothesis of premorbid hypermetabolism in ALS patients. Coexistence of coronary heart disease possibly has a negative influence on respiratory involvement. Contraceptives could be beneficial due to a protective effect of estrogen. Information on influencing factors can help to elucidate the pathogenesis of ALS or provide approaches for possible therapeutic options.
Source: Journal of Neurology - April 6, 2020 Category: Neurology Source Type: research

Misdiagnoses and delay of diagnoses in Moyamoya angiopathy —a large Caucasian case series
ConclusionsThis is the first systematic report which shows that patients with MMA are at high risk to be falsely diagnosed and treated. Depiction of typical vascular abnormalities in angiopathy is essential. Normal CSF cell counts, negative oligoclonal bands, and lack of infratentorial lesions as well as gadolinium-positive T1 lesions on MRI may be red flags differentiating this vasculopathy from vasculitis and MS.
Source: Journal of Neurology - April 16, 2019 Category: Neurology Source Type: research

Clinical presentation of Moyamoya angiopathy in Europeans: experiences from Germany with 200 patients
ConclusionsCompared with Asian data, cerebral hemorrhages are infrequent and female predominance is accentuated among European Caucasians. Some former unknown rare features like associated livedo racemosa, dysgenesis of corpus callosum and associated syncope have been discovered systematically for the first time in this huge European Caucasian cohort.
Source: Journal of Neurology - March 12, 2019 Category: Neurology Source Type: research

Efficacy of STA –MCA bypass surgery in moyamoya angiopathy: long-term follow-up of the Caucasian Krupp Hospital cohort with 81 procedures
ConclusionDirect STA –MCA bypass is an effective therapy in Caucasian patients with hemodynamically compromised MA.
Source: Journal of Neurology - October 1, 2018 Category: Neurology Source Type: research

Initiating anticoagulant therapy after ICH is associated with patient characteristics and treatment recommendations
ConclusionsClear treatment recommendations by attending stroke physicians significantly influence OAC initiation after ICH. OAC were more frequently recommended and started in younger patients with better functional recovery independent from intracranial complications. This might represent an important determinant of observed beneficial associations, hinting towards an indication bias which might affect observational analyses.
Source: Journal of Neurology - August 20, 2018 Category: Neurology Source Type: research