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Psychological impact of COVID-19 containment on CADASIL patients
ConclusionPsychological impact of the containment was limited in CADASIL patients and did not appear related to the disease status. About 9% of patients presented with significant posttraumatic and stressor-related disorder manifestations which were predicted by living alone, unemployment, or exhaustion related to parental burden.
Source: Journal of Neurology - March 4, 2023 Category: Neurology Source Type: research

White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke —results from the PROSCIS-B study
ConclusionHigher WMH burden was associated with a significant decline in cognition 3 years post-stroke in this cohort of first-ever stroke patients.
Source: Journal of Neurology - December 6, 2022 Category: Neurology Source Type: research

The advances of post-stroke depression: 2021 update
AbstractPost-stroke depression (PSD) is one of common and serious sequelae of stroke. Approximately, one in three stroke survivors suffered from depression after stroke. It heavily affected functional rehabilitation, which leaded to poor quality of life. What is worse, it is strongly associated with high mortality. In this review, we aimed to derive a comprehensive and integrated understanding of PSD according to recently published papers and previous classic articles. Based on the considerable number of studies, we found that within 2  years incidence of PSD has a range from 11 to 41%. Many factors contribute to the occu...
Source: Journal of Neurology - May 30, 2021 Category: Neurology Source Type: research

Multiverse to inform neurological research: an example using recovery outcome of neglect
ConclusionsThis investigation demonstrates the utility of multiverse analysis techniques for evaluating effect robustness and identifying potential sources of bias within neurological research.
Source: Journal of Neurology - May 29, 2021 Category: Neurology Source Type: research

Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study
ConclusionsObstructive sleep apnea with comorbid ischemic stroke may be a distinctive phenotype which responds quite well to trazodone, decreasing OSA severity without increasing nocturnal hypoxia.Trial RegistrationClinicaltrials.gov: NCT04162743, 2019/11/10.
Source: Journal of Neurology - February 24, 2021 Category: Neurology Source Type: research

Long-term psychosocial outcome following mild traumatic brain injury and minor stroke: a direct longitudinal comparison
ConclusionsPsychosocial outcome is largely comparable following mTBI and minor stroke. Specific attention should be paid to anxiety symptoms and cognitive problems in daily life for which uniform aftercare seems appropriate.
Source: Journal of Neurology - January 13, 2021 Category: Neurology Source Type: research

Early cognitive and emotional outcome after stroke is independent of discharge destination
ConclusionsCognitive and emotional problems at two  months post stroke were comparable between patients discharged home and those discharged to inpatient rehabilitation. For patients discharged home, cognitive complaints were predictive of long-term participation.
Source: Journal of Neurology - June 23, 2020 Category: Neurology Source Type: research

Impact of comorbidities and co-medication on disease onset and progression in a large German ALS patient group
ConclusionsOur results suggest stroke, lower BMI, and regular physical activity as risk factors for ALS. Strokes could be a possible trigger of the pathogenetic pathway of ALS and the lower BMI with consecutively lower rate of hyperlipidemia supports the hypothesis of premorbid hypermetabolism in ALS patients. Coexistence of coronary heart disease possibly has a negative influence on respiratory involvement. Contraceptives could be beneficial due to a protective effect of estrogen. Information on influencing factors can help to elucidate the pathogenesis of ALS or provide approaches for possible therapeutic options.
Source: Journal of Neurology - April 6, 2020 Category: Neurology Source Type: research

Depressive symptoms in stroke patients treated and non-treated with intravenous thrombolytic therapy: a 1-year follow-up study
Conclusions(1) Thrombolysed and non-thrombolysed stroke survivors had similar frequency of depressive symptoms although the thrombolysed patients had more severe neurological deficits in the acute phase. It can be assumed that if thrombolysis had not been used, depressive symptoms would have been more frequent. (2) Lack of the rt-PA treatment was associated with three-time greater odds of screening for PSD at 3  months post-stroke, after adjustment for other PSD correlates. (3) Therefore, thrombolytic therapy seems to have a positive, but indirect, effect on patients’ mood, especially in the first months after stroke. (...
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research

Neurological diseases and risk of suicide attempt: a case –control study
ConclusionNine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.
Source: Journal of Neurology - March 21, 2018 Category: Neurology Source Type: research

Retraction Note to: Factors associated with post-stroke depression and fatigue: lesion location and coping styles
AbstractThe Editors-in-Chief are retracting the original article because it shows significant overlap with an article previously published by the authors [1]. All authors agree to this retraction.
Source: Journal of Neurology - January 18, 2018 Category: Neurology Source Type: research

Suicidal ideation and attempts in patients with stroke: a population-based study
Abstract Stroke is known to be associated with an increase in the risk for suicide. However, there are very few population-based studies investigating the risk of suicidal ideation and attempts in patients with stroke. The purpose of this study was to compare the risk of suicidal ideation and attempts between patients with stroke and population without stroke using nationwide survey data. Individual-level data were obtained from 228,735 participants (4560 with stroke and 224,175 without stroke) of the 2013 Korean Community Health Survey. Demographic characteristics, socioeconomic status, physical health status, an...
Source: Journal of Neurology - July 12, 2016 Category: Neurology Source Type: research

Factors associated with post-stroke depression and fatigue: lesion location and coping styles
Abstract Post-stroke depression (PSD) and post-stroke fatigue (PSF) are frequent and persistent problems among stroke survivors. Therefore, awareness of signs and symptoms of PSD and PSF is important for their treatment and recovery from stroke. Additionally, since sudden serious illness can result in disequilibrium, early institution of a coping process is essential to restoring stability. The brain damage of stroke leaves patients with unique physical and mental dysfunctions for which coping maybe a key resource while rebuilding lives. We evaluated 368 consecutive patients with acute ischemic stroke for post-str...
Source: Journal of Neurology - November 14, 2015 Category: Neurology Source Type: research