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White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke —results from the PROSCIS-B study
ConclusionHigher WMH burden was associated with a significant decline in cognition 3 years post-stroke in this cohort of first-ever stroke patients.
Source: Journal of Neurology - December 6, 2022 Category: Neurology Source Type: research

Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis
ConclusionMigraine, especially migraine with aura, is associated with myocardial infarction and stroke. Migraine with aura increases the risk of overall cardiovascular mortality.
Source: Journal of Neurology - January 8, 2022 Category: Neurology Source Type: research

Cardiovascular magnetic resonance imaging and its role in the investigation of stroke: an update
AbstractRecent advances in complementary diagnostic exams have helped to clarify stroke etiology, not only by helping to confirm established stroke causes but also by unveiling new possible stroke mechanisms. Etiological investigation for cardioembolic stroke has benefited in the last years from information provided by studies analysing serum biomarkers, heart rhythm monitoring and imaging methods like cardiovascular magnetic resonance (CMR) imaging. CMR has been particularly important for the characterization of possible new cardioembolic stroke mechanisms including atrial cardiomyopathy, silent myocardial infarction and cardiomyopathies.
Source: Journal of Neurology - January 13, 2021 Category: Neurology Source Type: research

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis
DiscussionAntiplatelet –HTPR may predict risks of recurrent vascular events/outcomes in CVD patients. Given the heterogeneity between studies, further prospective, multi-centre studies are warranted.
Source: Journal of Neurology - June 8, 2020 Category: Neurology Source Type: research

GLP-1 receptor agonists in diabetes for stroke prevention: a systematic review and meta-analysis
ConclusionsAmong patients with type 2 DM,  GLP-1R agonists are beneficial for primary stroke, MACE, and cardiovascular mortality prevention. Further RCTs are needed to evaluate their role for secondary stroke prevention.
Source: Journal of Neurology - April 3, 2020 Category: Neurology Source Type: research

Genetic correlations and causal inferences in ischemic stroke
ConclusionsShared genetic overlaps might exist between ischemic stroke and physical activity, cardiometabolic factors, smoking, and lung function. We provided suggestive evidence for a potential causal role of LDL.P and LDL.C in ischemic stroke, particularly in large artery stroke. Future researches are required to confirm these findings.
Source: Journal of Neurology - March 13, 2020 Category: Neurology Source Type: research

Stroke in supplementary motor area mimicking functional disorder: a case report
We report a 59-year-old man with previous history for myocardial infarction, referred to emergency room with an acute dense right-side hemiplegia, positive Hoover sign, asymmetrical Babinski responses and intermittent ability to move his arm in some specific reflex actions despite plegia. Since brain computed tomography scan was unremarkable we could not be sure whether his symptoms were organic or functional until a diffusion weighted imaging of magnetic resonance imaging elucidated the situation. To our knowledge, there is only one case report in the literature prior to ours, presenting a supplementary motor area stroke ...
Source: Journal of Neurology - September 28, 2019 Category: Neurology Source Type: research

Carotid endarterectomy in patients with recurrent symptoms associated with an ipsilateral carotid artery near occlusion with full collapse
ConclusionIn patients with RSNOFC, CEA may be considered a potential treatment option. Although procedural risks in this small subgroup may be higher as compared to patients with low-to-moderate risk anatomy, this risk may outbalance the natural course.
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research

Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
ConclusionsAlthough data is limited, minocycline demonstrated efficacy and seems a promising neuroprotective agent in acute stroke patients, especially  in AIS subgroup. Further RCTs are needed to evaluate the efficacy and safety of minocycline among ICH patients.
Source: Journal of Neurology - June 14, 2018 Category: Neurology Source Type: research

Endovascular vs. medical therapy in symptomatic vertebral artery stenosis: a meta-analysis
AbstractThis meta-analysis aims to compare percutaneous transluminal angioplasty (PTA) to medical treatment (MT) for symptomatic vertebral artery stenosis (SVAS) treatment. We searched PubMed, Springer, Google Scholar, Clinical Trials, Cochrane Central, Chinese National Knowledge Infrastructure, and China Biological Medicine databases. All relevant comparative trials were included. All summary estimates were calculated by random-effect models. Ten comparative trials involving 672 patients were identified. Within 30-day follow-up, there was no significant difference between PTA plus MT and MT alone in vascular death, any st...
Source: Journal of Neurology - August 19, 2016 Category: Neurology Source Type: research

Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study
In conclusion, careful recording the features of the attack in patients with TMB can provide important information about the risk of future vascular events.
Source: Journal of Neurology - June 16, 2016 Category: Neurology Source Type: research

Antiplatelet drug resistance is associated with early neurological deterioration in acute minor ischemic stroke in the Chinese population
Abstract To evaluate the prevalence and risk factors of antiplatelet drug resistance and its association with early neurological deterioration (END) and recurrent ischemic stroke (RIS) in patients with acute minor stroke. Antiplatelet drug resistance was assessed by platelet aggregation assay in 426 patients with minor stroke who were receiving combined treatment of aspirin and clopidogrel. All patients were followed up for 90 days. The primary endpoint of the study was END within 10 days after admission. The secondary endpoints included RIS, myocardial infarction and death during 90 days of treatment. The safe...
Source: Journal of Neurology - June 2, 2016 Category: Neurology Source Type: research