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Carotid free-floating thrombus in COVID-19: a cerebrovascular disorder of cytokine storm-related immunothrombosis
ConclusionsCOVID-19-induced immunothrombosis possibly played a significant pathogenic role in CFFT.
Source: Neurological Sciences - May 13, 2023 Category: Neurology Source Type: research

Intravenous thrombolysis in CADASIL: report of two cases and a systematic review
ConclusionsAvailable data on intravenous thrombolysis in CADASIL patients are scarce but suggest that this treatment can be taken into consideration for these patients.
Source: Neurological Sciences - October 18, 2022 Category: Neurology Source Type: research

The impact of leptomeningeal collaterals in acute ischemic stroke: a systematic review and meta-analysis
ConclusionsThe relative risk of favorable clinical outcome is more in patients with good pretreatment CBF. This could be explained due to better chances of recanalization combined with a lesser risk of intracerebral hemorrhage with good CBF status.
Source: Neurological Sciences - October 4, 2022 Category: Neurology Source Type: research

Floating aortic arch thrombus involving the left common carotid artery complicated with ischemic stroke associated with cocaine use
ConclusionAortic thrombus should be suspected in patients without overt cardiovascular risk factors but with a recent history of cocaine use who presents with acute ischemic stroke.
Source: Neurological Sciences - August 17, 2022 Category: Neurology Source Type: research

Carotid free-floating thrombus during COVID-19 vaccine era: causality or not?
AbstractCarotid free-floating thrombus (FFT) is very rarely diagnosed in patients with acute ischemic stroke. It is a real clinical emergency due to the significant risk of death associated with thromboembolic complications. Herein, we present three patients with ischemic stroke caused by carotid FFT after less than 20  days from administration of mRNA vaccine BNT162b1 (Pfizer/BioNTech) for Severe Acute Respiratory Syndrome—CoronaVirus 2 (SARS-CoV-2). To our knowledge, these are the first cases reporting carotid FTT following SARS-CoV-2 vaccination.
Source: Neurological Sciences - August 3, 2022 Category: Neurology Source Type: research

Imaging patterns of cerebral ischemia in hypereosinophilic syndrome: case report and systematic review
ConclusionsBorder zone distribution of cerebral ischemia without hemodynamic compromise is the most frequent imaging pattern in patients with HES, occurring in 2/3 of patients who develop ischemic stroke.
Source: Neurological Sciences - August 1, 2022 Category: Neurology Source Type: research

Arterial intracranial thrombosis as the first manifestation of vaccine-induced immune thrombotic thrombocytopenia (VITT): a case report
We describe a severe case of vaccine-induced immune thrombotic thrombocytopenia (VITT) after the first dose of the ChAdOx1 nCoV-19 vaccine leading to massive ischemic stroke.MethodsA 42-year-old woman developed acute left hemiparesis (NIHSS 12) 9  days after the first vaccine dose.ResultsThe blood tests revealed low platelets (70 103/ μL) and severe increment of D-dimer (70,745 ng/mL FEU). Brain non-contrast computed tomography and multiphasic CT angiography demonstrated a right middle cerebral artery occlusion. The patient was treated with primary thrombectomy, steroids, immunoglobulin, and fondaparinux. Despite the tr...
Source: Neurological Sciences - January 13, 2022 Category: Neurology Source Type: research

Thrombolytic DNT and fatality and disability rates in acute ischemic stroke: a study from Bigdata Observatory Platform for Stroke of China
ConclusionsThe results did not show that shorter DNT for tPA administration was significantly associated with better 1-year outcomes.
Source: Neurological Sciences - September 3, 2021 Category: Neurology Source Type: research

Reperfusion therapy in a patient with early recurrence of ischemic stroke
We report a case addressing this issue.Case presentationWe present a patient who was successfully treated by mechanical thrombectomy (MT) for middle cerebral artery occlusion. Due to an early stroke recurrence, within 72  h after the first MT, he received systemic thrombolysis and repeated MT was performed with excellent clinical outcome.DiscussionWe discuss the aspects of reperfusion therapy for patients experiencing early stroke recurrence. Consideration was given to stroke etiology and off-label use of thrombolytic therapy. Also, effectiveness of repeated MT for early re-occlusion of initially reanalyzed vessel was eva...
Source: Neurological Sciences - September 3, 2021 Category: Neurology Source Type: research

Cerebral venous thrombosis: a retrospective unicentric analysis of clinical and neuroimaging characteristics
AbstractThrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of stroke, usually affecting young individuals. It has a variable clinical presentation ranging from mild cases presenting only headaches, to severe cases featuring encephalopathy, coma or status epilepticus. A retrospective cross-sectional study of patients treated in the outpatient department and in-hospital during the period from 2014 to 2020 at the Neurology Clinic —University Clinical Centre of Serbia was conducted. Forty-nine patients (24 men; 25 women) were included in the study. Twenty-three patients (46.9%) suffered a subacute fo...
Source: Neurological Sciences - August 4, 2021 Category: Neurology Source Type: research

Predictive value of admission neutrophil/lymphocyte ratio in symptomatic intracranial hemorrhage after stroke thrombolysis
ConclusionFor predicting SICH, NLR did not provide strong specificity and sensitivity. A precise cut-off value could not be found to predict the hemorrhagic transformation.
Source: Neurological Sciences - May 21, 2021 Category: Neurology Source Type: research

Thrombophilic alterations, migraine, and vascular disease: results from a case-control study
ConclusionsOur research documented a significative higher prevalence of aPL positivity and protein S deficiency in migraineurs than in controls. Data also showed an association between these alterations and some vascular thrombotic events in migraine patients. We can argue that thrombophilic disorders associated with migraine may contribute to the occurrence of vascular events.
Source: Neurological Sciences - January 20, 2021 Category: Neurology Source Type: research

Utility of Hounsfield unit in the diagnosis of tandem occlusion in acute ischemic stroke
ConclusionDespite a significant difference in thrombus attenuation in MCA occlusions with an additional extracranial ICA occlusion compared with isolated MCA occlusions, a relevant threshold of thrombus attenuation was not found.
Source: Neurological Sciences - October 14, 2020 Category: Neurology Source Type: research

Venous thromboembolism prevention with low molecular weight heparin may reduce hemorrhagic transformation in acute ischemic stroke
ConclusionsThis retrospective study suggests that SHPD may play a protective role in HT appearance and evolution, which requires verification by a randomized clinical trial.
Source: Neurological Sciences - March 23, 2020 Category: Neurology Source Type: research

Value of thrombus imaging in predicting the outcomes of patients with large-vessel occlusive strokes after endovascular therapy
ConclusionImaging of thrombus can be used as an aseessment tool to predict the outcomes and it needs further studies in the future.
Source: Neurological Sciences - February 20, 2020 Category: Neurology Source Type: research

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