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Total 61 results found since Jan 2013.

Nonlinear temporal dynamics of cerebral small vessel disease: The RUN DMC study
Conclusions: SVD progression is nonlinear, accelerating over time, and a highly dynamic process, with progression interrupted by reduction in some, in a population that on average shows progression.
Source: Neurology - October 9, 2017 Category: Neurology Authors: van Leijsen, E. M. C., van Uden, I. W. M., Ghafoorian, M., Bergkamp, M. I., Lohner, V., Kooijmans, E. C. M., van der Holst, H. M., Tuladhar, A. M., Norris, D. G., van Dijk, E. J., Rutten-Jacobs, L. C. A., Platel, B., Klijn, C. J. M., de Leeuw, F.-E. Tags: MRI, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Localization of primary progressive apraxia of speech using functional MRI - a case study (P4.196)
Conclusions:This data suggests task-specific alterations in functional activation in multiple focal areas implicated in PPAOS. These results are consistent with studies investigating AOS in stroke. Continuation of this investigation will be done with a pilot study using a greater number of subjects in order to gain further insights into the pathophysiology of PPAOS.Disclosure: Dr. Spengler has nothing to disclose. Dr. Reyes Baerga has nothing to disclose. Dr. Pattany has nothing to disclose. Dr. Gomes-Osman has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Luca has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Spengler, D., Baerga, D. R., Pattany, P., Gomes-Osman, J., Adams, D., Luca, C. Tags: Behavioral and Cognitive Neurology: Neurodegenerative Disorders Source Type: research

Systematic Review and Meta-Analysis of Cohort Studies Examining Effect of Anticoagulation and Risk of Cerebral Hemorrhage in patients with Cerebral Microbleeds (P2.276)
Conclusions:Results of this meta-analysis suggest that patients with CMBs started on anticoagulation after ischemic stroke are more likely to have ICH outcomes than patients without CMBs. However, the study was limited by small sample sizes based on extracted data and lack of quality prospective cohort studies meeting inclusion criteria. Further investigation is necessary to conclude increased risk of ICH in this patient population.Disclosure: Dr. Faheem has nothing to disclose. Dr. Wang has received research support from TEVA Pharmaceuticals Ltd. Dr. Gronseth has received personal compensation in an editorial capacity for...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Faheem, N., Wang, Y., Gronseth, G. Tags: Intracerebral Hemorrhage Source Type: research

Misdiagnosis of CADASIL: A single Medical Center experience (P1.251)
Conclusions:CADASIL is the most prevalent monogenic cerebral small-vessel arteriopathy. Despite wide availability of genetic testing, misdiagnosis and delay diagnosis are common. We encourage for enhanced awareness of CADASIL among patients with migraines with aura, recurrent TIAs or subcortical ischemic strokes, and mood disorder, in order to provide appropriate multidisciplinary treatment, psychological support and genetic counselingStudy Supported by: n/aDisclosure: Dr. Ortiz-Garcia has nothing to disclose. Dr. Orjuela has nothing to disclose. Dr. Sweis has nothing to disclose. Dr. Biller has received personal compensat...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ortiz-Garcia, J., Orjuela, K., Sweis, R., Biller, J. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Recurrent transient hemiparesis and a novel ATP1A2 mutation (P3.220)
Conclusions:This case identifies a novel, potentially pathogenic mutation of the ATP1A2 gene corresponding to a phenotype of a rare migraine variant and contributes to our evolving understanding of migraine molecular genetics and pathophysiology.Study Supported by:Disclosure: Dr. Stredny has nothing to disclose. Dr. Winden has nothing to disclose. Dr. Danehy has nothing to disclose. Dr. Robertson has nothing to disclose. Dr. Trenor has nothing to disclose. Dr. Rivkin has nothing to disclose. Dr. Lehman has nothing to disclose. Dr. Bernson-Leung has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Stredny, C., Winden, K., Danehy, A., Robertson, R., Trenor, C., Rivkin, M., Lehman, L., Bernson-Leung, M. Tags: Child Neurology I Source Type: research

Early cerebral ischemic events in symptomatic carotid stenosis are related to plaque inflammation (P6.292)
Conclusions:FDG-PET/CT and HR-MRI imaging of carotid stenosis helps in identification of patients at higher risk of subsequent cerebral ischemic events and may aid in better therapeutic decision-making.Study Supported by: This study is supported by a grant from the National Medical Research Council, Singapore.Disclosure: Dr. Tan has nothing to disclose. Dr. Paliwal has nothing to disclose. Dr. Sinha has nothing to disclose. Dr. Ting has nothing to disclose. Dr. Teoh has nothing to disclose. Dr. Chan has nothing to disclose. Dr. Sharma has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tan, C. H., Paliwal, P., Sinha, A., Ting, E., Teoh, H. L., Chan, B., Sharma, V. K. Tags: Prevention of Cerebrovascular Disease Source Type: research

A Rare Case of Central Nervous System Tuberculosis Presenting as Transient Splenial Lesion: Case Report and Literature Review (P1.320)
Conclusions:Based on literature review, the transient splenial lesion of corpus callosum has never been reported in patients with CNS tuberculosis. The mechanisms underlying transient splenial lesions may due to intramyelinic edema and inflammatory cell infiltration. This hypothesis supported by the MR spectroscopy findings in our patient. Since early diagnosis and treatment can reduce mortality and morbidity, patients with isolated splenial lesion warrant diagnostic tests for CNS tuberculosis.Study Supported by:The authors report no disclosures relevant to the manuscript.Disclosure: Dr. Wu has nothing to disclose. Dr. Che...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wu, J.-W., Chen, S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Pituitary apoplexy causing bilateral anterior cerebral infarction (P3.283)
Conclusions:Pituitary apoplexy occurs when a pituitary tumor, typically macroadenoma, hemorrhages or infarcts resulting in a rapid expansion of the hypophysis and compression of adjacent structures, including the internal carotid arteries (ICA)which can result in cerebral ischemia. Proposed mechanisms of cerebral infarction to date include both direct compression or vasospasm of the ICA. Vasospasm as a cause is proposed to be from either extravasation of blood into the subarachnoid space or release of vasoactive substances by the tumor itself. This matter is still debated in the literature. Emergent recognition and imaging...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Vargas, A., Testai, F. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Isolated pseudoabducens palsy in acute thalamic stroke (P3.284)
Conclusions:This case supports the hypothesis that a lesion can cause isolated esotropia by interrupting descending inhibitory convergence pathways that traverse the paramedian thalamus and decussate in the subthalamic region to innervate the contralateral third oculomotor nucleus.Disclosure: Dr. Ghasemi has nothing to disclose. Dr. Riaz has nothing to disclose. Dr. Bjornsdottir has nothing to disclose. Dr. Paydarfar has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ghasemi, M., Riaz, N., Bjornsdottir, A., Paydarfar, D. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Postpartum cardiomyopathy with cardioembolic stroke (p3.298)
Conclusions:Peripartum cardiomyopathy is a rare cause of stroke. Though seldom described, it should be considered in appropriate female patients presenting with neurological deficits. Definitive therapy with anticoagulation should be considered to prevent further complications.Disclosure: Dr. Kumbham has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Masangkay has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kumbham, P., Sharma, B., Patel, A., Masangkay, N. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Hypoperfusion, vascular pruning, and transient hemiparesis mimicking stroke in transient erythroblastopenia of childhood (P4.161)
Conclusions:The patient’s transient cerebrovascular and electrophysiologic abnormalities are consistent with those described in the literature for hemiplegic migraine. However, he did not meet International Headache Society criteria for hemiplegic migraine, such as headache with presentation or recurrent events. We hypothesize that transient vascular narrowing and resultant hypoperfusion, compounded by cerebral hypoxia from significant anemia, may explain the transient neurologic symptoms concurrent with anemia in TEC.Disclosure: Dr. Calahan has nothing to disclose. Dr. Lehman has nothing to disclose. Dr. Rivkin has ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Calahan, C., Lehman, L., Rivkin, M., Lipton, J., Danehy, A., Robertson, R., Ozuah, N., Trenor, C., Bernson-Leung, M. Tags: Child Neurology II Source Type: research

Cerebral Microbleeds in patients with asymptomatic carotid stenosis. (P3.074)
Conclusions:Our study demonstrated high frequency of CMB in asymptomatic patients with ACS >70%. After that, some questions remain to be answered: are microbleeds a marker with potential to change the management of ACS?Disclosure: Dr. Oliveira e Sousa has nothing to disclose. Dr. Carrijo Filho has nothing to disclose. Dr. Cendes has nothing to disclose. Dr. Coan has nothing to disclose. Dr. Min has nothing to disclose. Dr. Avelar has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Oliveira e Sousa, A. A. V., Filho, S. L. C., Cendes, F., Coan, A. C., Min, L. L., Avelar, W. M. Tags: Cerebrovascular Disease and Interventional Neurology ePoster Session Source Type: research

Cardiac MRI Has Limited Additional Yield in Cryptogenic Stroke Evaluation (P1.225)
Conclusions: The addition of cMRI to TEE in the diagnostic evaluation of CS results in 9[percnt] reclassification of CCS subtype, with only 3[percnt] reclassified as a non-CS subtype. Our results indicate the need for cost-effectiveness studies assessing the role of cMRI in determining ischemic stroke etiology.Disclosure: Dr. Liberman has nothing to disclose. Dr. Kalani has nothing to disclose. Dr. Aw-Zoretic has nothing to disclose. Dr. Sondag has nothing to disclose. Dr. Daruwalla has nothing to disclose. Dr. Furiasse has nothing to disclose. Dr. Carr has nothing to disclose. Dr. Collins has nothing to disclose. Dr. Prab...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Liberman, A., Kalani, R., Aw-Zoretic, J., Sondag, M., Daruwalla, V., Furiasse, N., Carr, J., Collins, J., Prabhakaran, S. Tags: Cardiac Mechanisms and Complications of Stroke Source Type: research

Plaque Inflammation in Recently Symptomatic Carotid Stenosis Predicts Recurrent Cerebral Ischemia (P1.233)
Conclusions: FDG-PET/CT and HR-MRI aid in the imaging of plaque inflammation and identification of patients with higher risk of subsequent cerebral ischemic events. This ongoing study intends to develop a robust prediction model for risk stratification based on luminal stenosis and plaque characteristics for better therapeutic decision-making.Disclosure: Dr. Woo has nothing to disclose. Dr. Bharatendu has nothing to disclose. Dr. Sinha has nothing to disclose. Dr. Ting has nothing to disclose. Dr. Paliwal has nothing to disclose. Dr. Kulkarni has nothing to disclose. Dr. Teoh has nothing to disclose. Dr. Chan has nothing t...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Woo, J. W., Bharatendu, C., Sinha, A., Ting, E., Paliwal, P., Kulkarni, A., Teoh, H. L., Chan, B., Hong, C., Heng, C. Y., Chen, J. T., Du, Z., Wong, L., Asp, S., Sharma, V. Tags: Carotid Disease Source Type: research

Provoked Re-Emergence of Ischemic Cerebral Events (PRICE) Syndrome: Getting Concrete About a Common Clinical Belief (P1.189)
Conclusions: When patients present as an acute stroke code with symptoms identical to a previous stroke, the PRICE syndrome may explain 21.7-38.3[percnt] of cases.Disclosure: Dr. Shenker has received personal compensation for activities with Behavioral Medical Interventions. Dr. Dugyala has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Shenker, J., Dugyala, V. Tags: Ischemic Stroke Outcomes Source Type: research