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Does compensatory hyperparathyroidism predispose to ischemic stroke? Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy; An alternative to vitamin D supplementation to prevent fractures in patients with MS; High prevalence of vitamin D deficiency and reduced bone mass in Parkinson's disease
Because of known issues leading to several retractions of papers by Y. Sato et al., the editors of Neurology® have, as a matter of due diligence, researched other papers that this group published in Neurology. To ensure that the scientific literature is correct, the Editor chooses to publish an Expression of Concern regarding 3 observational studies and a Letter to the Editor published in Neurology prior to the retracted clinical trials.1–4
Source: Neurology - September 18, 2017 Category: Neurology Tags: EXPRESSION OF CONCERN Source Type: research

Direct oral anticoagulant- vs vitamin K antagonist-related nontraumatic intracerebral hemorrhage
Conclusions: DOAC-related ICH is associated with smaller baseline hematoma volume and lesser neurologic deficit at hospital admission compared to VKA-related ICH.
Source: Neurology - September 11, 2017 Category: Neurology Authors: Tsivgoulis, G., Lioutas, V.-A., Varelas, P., Katsanos, A. H., Goyal, N., Mikulik, R., Barlinn, K., Krogias, C., Sharma, V. K., Vadikolias, K., Dardiotis, E., Karapanayiotides, T., Pappa, A., Zompola, C., Triantafyllou, S., Kargiotis, O., Ioakeimidis, M., Tags: Intracerebral hemorrhage ARTICLE Source Type: research

Association of parathyroid hormone with 20-year cognitive decline: The ARIC study
Conclusions: Our work does not support an independent influence of PTH on cognitive decline in this population-based cohort study.
Source: Neurology - August 28, 2017 Category: Neurology Authors: Kim, S. M., Zhao, D., Schneider, A. L. C., Korada, S. K., Lutsey, P. L., Guallar, E., Alonso, A., Windham, B. G., Gottesman, R. F., Michos, E. D. Tags: Endocrine, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation
Conclusions: In observational studies, anticoagulation with VKA is associated with a lower rate of IS than APA or no-ATM without increasing ICH recurrence significantly. A randomized controlled trial is needed to determine the net clinical benefit of anticoagulation in ICH survivors with AF.
Source: Neurology - August 14, 2017 Category: Neurology Authors: Korompoki, E., Filippidis, F. T., Nielsen, P. B., Del Giudice, A., Lip, G. Y. H., Kuramatsu, J. B., Huttner, H. B., Fang, J., Schulman, S., Marti-Fabregas, J., Gathier, C. S., Viswanathan, A., Biffi, A., Poli, D., Weimar, C., Malzahn, U., Heuschmann, P., Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Cardiac, Embolism, Intracerebral hemorrhage ARTICLE Source Type: research

Letter re: Early start of DOAC after ischemic stroke: Risk of intracranial hemorrhage and recurrent events
Seiffge et al.1 evaluated the effect of direct, non–vitamin K antagonist oral anticoagulants (DOACs) or vitamin K antagonists on intracranial hemorrhage (ICH) and recurrent ischemic events in patients with acute ischemic stroke or TIA and nonvalvular atrial fibrillation (NVAF). I have a concern about the study.
Source: Neurology - May 22, 2017 Category: Neurology Authors: Kawada, T. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Author response: Early start of DOAC after ischemic stroke: Risk of intracranial hemorrhage and recurrent events
We thank Prof. Kawada for his interest in our article.1 We agree that larger patient cohorts more accurately estimate the risk of intracranial hemorrhage (ICH) from direct, non–vitamin K antagonist oral anticoagulants (DOACs). However, the definition of ICH is crucial. In our study we looked at symptomatic ICH (sICH) only, and observed only 1 patient with sICH.1 In contrast, the cited study of Cappellari et al.2 looked at both sICH and asymptomatic ICH: Of the 7 patients with any ICH after DOAC start, only 1 had sICH. Therefore, the rates of sICH were comparable between the 2 studies.
Source: Neurology - May 22, 2017 Category: Neurology Authors: Seiffge, D. J., De Marchis, G. M. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers
Conclusions: Folic acid supplementation could reduce the stroke risk in regions without folic acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Zhao, M., Wu, G., Li, Y., Wang, X., Hou, F. F., Xu, X., Qin, X., Cai, Y. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), All epidemiology ARTICLE Source Type: research

Safety of OnabotulinumtoxinA Treatment With Concomitant Antithrombotic Therapy in Patients With Post-stroke Spasticity: A Pooled Analysis of Randomized, Double-Blind Studies (S56.008)
Conclusions:There is no apparent increased risk of bleeding complications in patients on antithrombotics following IM onabotA treatment; nonetheless, careful observation of the injection site and patient education of the potential for bleeding complications remain warranted.Study Supported by: Allergan plc, Dublin, IrelandDisclosure: Dr. Dimitrova has received personal compensation for activities with Allergan as an employee. Dr. Dimitrova holds stock and/or stock options in Allergan. Dr. James has received personal compensation for activities with Allergan and Chase Pharmaceuticals as an employee. Dr. Liu has received per...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Dimitrova, R., James, L., Liu, C., Orejudos, A., Yushmanova, I., Brin, M. Tags: Movement Disorders: Huntington ' s Disease and Drug-Induced Dyskinesias Source Type: research

Early start of DOAC after ischemic stroke: Risk of intracranial hemorrhage and recurrent events
Conclusions: Even if DOACs are often started early after an index event, the risk of ICH appears to be low. Among all patients receiving anticoagulation, the rate of recurrent events was 6 times higher than the rate of ICH.
Source: Neurology - October 30, 2016 Category: Neurology Authors: Seiffge, D. J., Traenka, C., Polymeris, A., Hert, L., Peters, N., Lyrer, P., Engelter, S. T., Bonati, L. H., De Marchis, G. M. Tags: Stroke prevention, Clinical trials Observational study (Cohort, Case control) ARTICLE Source Type: research

Safety of Mechanical Thrombectomy for Acute Ischemic Stroke in Patients on Novel Oral Anticoagulants (P1.196)
Conclusion: Patients on NOAC undergoing mechanical thrombectomy show a trend towards increased sICH compared to the warfarin group. This may warrant larger studies of safety of mechanical thrombectomy in the presence of NOACs.Disclosure: Dr. Sharma has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Ziayee has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Guada has nothing to disclose. Dr. Khandelwal has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Covidien/evV3 as a consultant and Steering Committee Member.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sharma, P., Atchaneeyasakul, K., Ziayee, H., Malik, A., Guada, L., Khandelwal, P., Ramdas, K., Yavagal, D. Tags: Acute Endovascular Therapy: Outcomes and Safety Source Type: research

Thiamine Deficiency While on Total Parenteral Nutrition Mimicking Acute Stroke: A Case Report (P3.217)
CONCLUSIONS: Thiamine deficiency mimicking stroke while on total parenteral nutrition has been rarely documented. Recognition of this syndrome is critical as prompt treatment may reverse symptoms.Disclosure: Dr. Parker has nothing to disclose. Dr. Marafie has nothing to disclose. Dr. Wolf has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Parker, A., Marafie, D., Wolf, V. Tags: Neurocritical Care: Clinical Science and Therapeutics Source Type: research

Intracranial Hemorrhage on Warfarin: Time to Reversal Is of the Essence (I6.004)
Conclusions: We propose a "recommended reversal time" of less than 200 minutes for Vitamin K antagonists.Disclosure: Dr. Mehta has nothing to disclose. Dr. Jones has nothing to disclose. Dr. Ruiz Cuero has nothing to disclose. Dr. Wellwood has nothing to disclose. Dr. Rehman has nothing to disclose. Dr. Mitsias has nothing to disclose. Dr. Varelas has received personal compensation for activities with UCB Pharma as an advisory board member.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Mehta, C., Jones, M., Ruiz Cuero, M., Wellwood, J., Rehman, M., Mitsias, P., Varelas, P. Tags: Future Directions and Challenges in Stroke Team Action Therapy (STAT) Data Blitz Presentations Source Type: research

Intracranial Hemorrhage on Warfarin: Time to Reversal Is of the Essence (S16.008)
Conclusions: We propose a "recommended reversal time" of less than 200 minutes for Vitamin K antagonists.Disclosure: Dr. Mehta has nothing to disclose. Dr. Jones has nothing to disclose. Dr. Ruiz Cuero has nothing to disclose. Dr. Wellwood has nothing to disclose. Dr. Rehman has nothing to disclose. Dr. Mitsias has nothing to disclose. Dr. Varelas has received personal compensation for activities with UCB Pharma as an advisory board member.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Mehta, C., Jones, M., Ruiz Cuero, M., Wellwood, J., Rehman, M., Mitsias, P., Varelas, P. Tags: Prehospital/Emergency Room Stroke Care and Intracerebral Hemorrhage Source Type: research

Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke
Conclusions: Our data identify a genetic contribution to inflammatory and hemostatic biomarkers in a stroke population. Additionally, our results suggest shared genetic contributions to circulating CRP levels measured poststroke and risk for incident and recurrent ischemic stroke. These data broaden our understanding of genetic contributors to biomarker variation and ischemic stroke risk, which should be useful in clinical risk evaluation.
Source: Neurology - January 25, 2016 Category: Neurology Authors: Williams, S. R., Hsu, F.-C., Keene, K. L., Chen, W.-M., Nelson, S., Southerland, A. M., Madden, E. B., Coull, B., Gogarten, S. M., Furie, K. L., Dzhivhuho, G., Rowles, J. L., Mehndiratta, P., Malik, R., Dupuis, J., Lin, H., Seshadri, S., Rich, S. S., Sale Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology, All Genetics, Association studies in genetics ARTICLE Source Type: research

Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type
Conclusions: In this small prospective observational study, patients with NOAC-associated ICH had smaller ICH volumes and better clinical outcomes compared with warfarin-associated ICH.
Source: Neurology - January 25, 2016 Category: Neurology Authors: Wilson, D., Charidimou, A., Shakeshaft, C., Ambler, G., White, M., Cohen, H., Yousry, T., Al-Shahi Salman, R., Lip, G. Y. H., Brown, M. M., Jager, H. R., Werring, D. J., On behalf of the CROMIS-2 collaborators Tags: Prognosis, Clinical trials Observational study (Cohort, Case control), Intracerebral hemorrhage ARTICLE Source Type: research

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