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Zika associated Guillain-Barre syndrome in the United States (P2.327)
Conclusions:Zika can induce GBS after a brief viral illness. Neuropathy can be a mixture of demyelinating and axonal. Dysautonomia may also be present including severe dysphagia, orthostatics and retention.Zika RNA has a short detection window in serum and CSF making a diagnosis time sensitive. Serological assays using IgM and IgG cross-react with other flaviviruses making them unable to differentiate between recent Zika exposure and cross reactivity with Dengue and Chikungunya. Our pt likely had prior exposure to Dengue, being from an endemic area. Prior Dengue exposure may possibly modulate the response to Zika via antib...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tantillo, G., Sclar, G., Vasa, C., Shin, S., Sivak, M. Tags: Zika, Chikungunya, West Nile Virus, and Other Viral Infections I Source Type: research

Neurotoxocariasis, a treatable infectious etiology of Stroke (P3.318)
Conclusions:Toxocara infection is an uncommon but treatable etiology of stroke, and should be particularly considered in patients with eosinophilia, positive serology, myocarditis and embolic strokes.Disclosure: Dr. Garcia Monco has nothing to disclose. Dr. Azkune Calle has nothing to disclose. Dr. Ruisanchez nieva has nothing to disclose. Dr. Anguizola Tamayo has nothing to disclose. Dr. Pardina Vilella has nothing to disclose. Dr. Bocos Portillo has nothing to disclose. Dr. Gomez-Beldarrain has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Monco, J. G., Calle, I. A., nieva, A. R., Tamayo, D. A., Vilella, L. P., Portillo, J. B., Gomez-Beldarrain, M. Tags: Fungal and Parasitic Disease of the Nervous System Source Type: research

PiB-PET detects transthyretin-related cerebral amyloid angiopathy
Transthyretin (TTR) is an amyloidogenic protein synthesized primarily (>95%) by the liver and, to a lesser extent, by the choroid plexuses and retinal pigment epithelium. Hereditary TTR amyloidosis (ATTR) is a multisystem disorder that may manifest with 3 main clinical phenotypes: familial amyloid polyneuropathy (FAP), familial amyloid cardiomyopathy, and familial leptomeningeal amyloidosis.1 TTR-FAP is the most common presentation. More than 130 autosomal dominant mutations cause ATTR, with the Val30Met mutation being the most frequent variant worldwide: prevalence of up to 1:1,000 in endemic regions of Portugal, Swede...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Cavallaro, T., Klunk, W. Tags: PET, Peripheral neuropathy, All Cerebrovascular disease/Stroke, All Genetics EDITORIALS Source Type: research

Chagas Disease and Stroke: Frequency and Clinical Correlates (P3.235)
Conclusions: Patients presenting with stroke and CD had more cardiac impairment and cardioembolic events than non-CD patients. Better healthcare of stroke patients and CD is required as these patients were readmitted more frequently than those without CDDisclosure: Dr. Meira has nothing to disclose. Dr. Teixeira has nothing to disclose. Dr. Nunes has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Meira, F., Teixeira, A., Nunes, M. d. C. Tags: Stroke in the Young Source Type: research

Brachial Plexus Neuritis as Presenting Manifestation of Disseminated Coccidioidomycosis. (P6.323)
CONCLUSIONS:This is the first reported case of coccidioidomycosis presenting with PNS involvement. Both remote inflammatory changes and direct local fungal invasion noted in this case highlight the wide spectrum of clinico-pathological presentations seen in coccidioidomycosis infection. As this fungal disease is identified with increasing frequency, clinicians should be aware of its atypical manifestations. Study Supported by: Disclosure: Dr. Shah has nothing to disclose. Dr. Liao has nothing to disclose. Dr. Shanina has nothing to disclose. Dr. Smith has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shah, R., Liao, B., Shanina, E., Smith, G. Tags: Fungi, Parasites, and Other Infectious Disorders Source Type: research