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Prospective association between {beta}2-microglobulin levels and ischemic stroke risk among women
Conclusion: High levels of B2M were associated with an increased risk of ischemic stroke among women.
Source: Neurology - June 5, 2017 Category: Neurology Authors: Rist, P. M., Jimenez, M. C., Rexrode, K. M. Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

Probable REM sleep behavior disorder and risk of stroke: A prospective study
Conclusions: Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Ma, C., Pavlova, M., Liu, Y., Liu, Y., Huangfu, C., Wu, S., Gao, X. Tags: All Cerebrovascular disease/Stroke, All Sleep Disorders, Cohort studies ARTICLE Source Type: research

Stroke like migraine attacks after radiation therapy (SMART) syndrome a case series of three patients (P6.179)
Conclusions:Our patients represent the first case series of SMART syndrome in a single institution. Our cases share similarities to the prior reports in the literature and highlights the clinical and MRI triad of acute onset headaches, neurological deficits and MRI findings of transient contrast enhancement of the cortex with white matter sparing in a previous radiation field.Disclosure: Dr. rauf has nothing to disclose. Dr. Boulter has nothing to disclose. Dr. Imitola has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Rauf, Y., Boulter, D., Imitola, J. Tags: Neurologic Complications of Cancer Source Type: research

Stroke like syndrome and simple partial seizures secondary to intrathecal methotrexate use for the treatment of acute lymphocytic leukemia. (p6.181)
Conclusions:Our case may be the first reported of seizures and stroke like syndrome in the same patient for ALL treated with MTX. Clinicians should include Methotrexate induced leukoencephalopathy in their differential of seizures, stroke like syndrome and a combination of both. MRI DWI, ADC and FLAIR images should be included in the diagnostic evaluation of MTX induced encephalopathy especially with IT methotrexate.Disclosure: Dr. Fares has nothing to disclose. Dr. Silliman has received research support from Sanofi Genzyme, Biogen Idec, Bristol Myers and Novartis.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Fares, M.-A., Silliman, S. Tags: Neurologic Complications of Cancer Source Type: research

Neurologic manifestations of geriatric patients with cancer (P6.188)
Conclusions:Neurologic manifestations are reported in about 40% of patients with cancer, approximately half of living patients with cancer are over 65 years of age, this increase merits the medical and related personnel to be prepared and recognize, diagnose and treat this highly morbid conditions. Neurologic manifestations and diagnoses in patients with cancer are different in the elderly and should be treated individually; the present work offers information regarding clinical symptoms and neurologic diagnoses in this population.Disclosure: Dr. Cacho Diaz has nothing to disclose. Dr. Lorenzana-Mendoza has nothing to disc...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Diaz, B. C., Lorenzana-Mendoza, N., Soto, G. R., Gomez, A. H. Tags: Neurologic Complications of Cancer Source Type: research

Recurrent Stroke after Silent Brain Infarction in Patients with Primary Brain Tumors (S51.007)
Conclusions:The short-term risk of recurrent ischemic stroke in patients with PBTs was substantial and the risk was comparable whether the stroke was silent or symptomatic.Study Supported by: Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke. Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund.Disclosure: Dr. Parikh has nothing to disclose. Dr. Burch has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel has received personal ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parikh, N., Burch, J., Kamel, H., DeAngelis, L., Navi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Probable rapid eye movement sleep behavior disorder and risk of stroke: a prospective study (P4.302)
Conclusions:Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.Study Supported by: The National Institute of Neurological Disorders And Stroke at the National Institutes of Health (NINDS 5R21NS087235-02 to X.G.)Disclosure: Dr. Ma has nothing to disclose. Dr. Pavlova has received research support from Lundbeck and Biomobie Corporation. Dr. Liu has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Huangfu has nothing to di...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ma, C., Pavlova, M., Liu, Y., Liu, Y., Huangfu, C., Wu, S., Gao, X. Tags: Neuroepidemiology: Cerebrovascular Disease I Source Type: research

MYSTICOL: A multisite, double-blind, randomized, placebo-controlled trial of rimabotulinumtoxinB for the treatment of sialorrhea in Parkinsons disease (PD) and other neurological conditions (P3.026)
Conclusions:Injection of rimabotulinumtoxinB (Myobloc) into the parotid and submandibular glands wase effective for the treatment of sialorrhea in patients with PD and other neurologic disorders, atf both 2500U and 3500U treatment arms. Injections were generally well toleratedStudy Supported by: US WorldMedsDisclosure: Dr. Isaacson has nothing to disclose. Dr. Jackson has received personal compensation for activities with GLG, Guidepoint Global, Marathon Pharmaceuticals, OneWorld Meds and Cytokinetics as a consultant. Dr. Jackson has received research support from OneWorld Meds and Cytokinetics. Dr. Molho has received pers...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Isaacson, S., Jackson, C., Molho, E., Trosch, R., Ondo, W., Clinch, T. Tags: Movement Disorders: Dystonia and Neurotoxin Therapies Source Type: research

The Vertebral Body Infarct Sign: A Case of Thoracic Spinal Cord Ischemic Stroke (P3.292)
Conclusions:While the vertebral body infarct sign is often recognized by neuro-radiologists, it is still relatively unknown to practicing neurologists. Early recognition of spinal cord infarct allows for timely evaluation for precipitating factors and initiation of secondary preventative therapies to decrease risk of further vascular events.Disclosure: Dr. Chan has nothing to disclose. Dr. Chan has nothing to disclose. Dr. Farooque has nothing to disclose. Dr. Nowak has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chan, D., Chan, A., Farooque, P., Nowak, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Letter re: Excess mortality and hospitalized morbidity in newly treated epilepsy patients
I read with interest the article by Chen et al.1 on the burden of mortality and hospitalized morbidity in newly treated patients with epilepsy in Hong Kong. The authors documented a very high rate of physical and psychiatric comorbidities in the cohort of patients with epilepsy, especially those on enzyme-inducing antiepileptic drugs (EIAEDs). While psychiatric comorbidities in patients with epilepsy have been well-documented and are thought to have a bidirectional relationship, the physical comorbidities (increased cancer, stroke, and cardiovascular disease [CVD] risk) are less well-reported and, if substantiated in other...
Source: Neurology - January 29, 2017 Category: Neurology Authors: Sethi, N. K. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Excess mortality and hospitalized morbidity in newly treated epilepsy patients
Conclusions: Newly treated epilepsy patients bear excess mortality and hospitalization risks. They have higher risk of developing stroke, ischemic heart disease, and cancer. Treatment with EIAEDs was associated with increased overall morbidity.
Source: Neurology - August 14, 2016 Category: Neurology Authors: Chen, Z., Liew, D., Kwan, P. Tags: All Epilepsy/Seizures, Antiepileptic drugs ARTICLE Source Type: research

Lifetime direct costs of stroke for indigenous patients adjusted for comorbidities
Conclusions: The costs of stroke for indigenous people and patients with different comorbidities are substantial and an integrated prevention strategy is needed.
Source: Neurology - July 31, 2016 Category: Neurology Authors: Zhao, Y., Condon, J., Lawton, P., He, V., Cadilhac, D. A. Tags: Cost effectiveness/economic, All Cerebrovascular disease/Stroke, Cohort studies ARTICLE Source Type: research

Pre-Mixing tPA: Moving Past Gestalt (P2.303)
Conclusions: While pre-mixing tPA does not incur financial risk as drug manufacturers replace unused vials without cost, stroke centers remain wary of wasting the drug. We believe succinct criteria can reduce avoidable tPA waste, allowing health care providers to remain fiscally responsible while ensuring AIS patients are treated as fast as possible.Disclosure: Dr. McCarthy has nothing to disclose. Dr. Caputo has nothing to disclose. Dr. Whaley has received personal compensation for activities with Clinical Data Management/Neurobase and Genentech. Dr. Fanale has received personal compensation for activities with Genentech,...
Source: Neurology - April 3, 2016 Category: Neurology Authors: McCarthy, K., Caputo, L., Whaley, M., Fanale, C., Bar-Or, D. Tags: Acute Therapy: IV t-PA Source Type: research

Reserve, Resilience and Recovery in Stroke: A Meta-Narrative Review (P3.199)
Conclusion: There is an urgent need to individualize outcomes in stroke systematically by implementing well validated concepts from various related fields to improve patient centered decision-making in acute stroke care.Disclosure: Dr. Dangayach has nothing to disclose. Dr. Grewal has nothing to disclose. Dr. Gordon has nothing to disclose. Dr. Mayer has received research support from Non-Invasive Medical Systems, Inc. and General Electric.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Dangayach, N., Grewal, H., Gordon, E., Mayer, S. Tags: Neurocritical Care: Clinical Science Source Type: research

Ischemic Stroke in Oncological Patients (P1.117)
Conclusions :In our series, serum DD levels, a marker of a hypercoagulable state, appear as a useful tool to identify patients with cryptogenic stroke and risk for underlying malignancy; while classical CRF failed to show differences between both groups (IS-C vs IS-nC). Interestingly, our patients showed a prevalence of a single vascular lesion subtype, against other previous series that reported a predominant pattern of multiple-lesions.Disclosure: Dr. Gatto has received personal compensation for activities with Tuteur, Bago, Novartis, and Glaxo-Smith Klein as a speaker and a scientific advisor. Dr. Persi has nothing to d...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gatto, E., Persi, G., Lisei, D., Da Prat de Magahlaes, G., Rattagan, L., Lopez Vicchi, M., Parisi, V. L. Tags: Cerebrovascular Disease: Epidemiology Source Type: research

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