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Combined lysis of thrombus with ultrasound and systemic tissue plasminogen activator for emergent revascularization in acute ischemic stroke (CLOTBUST‐ER): design and methodology of a multinational phase 3 trial
ConclusionsSince intravenous recombinant tissue‐plasminogen‐activator remains the only medical therapy to reverse ischemic stroke applicable in the emergency department, our trial will determine if the additional use of transcranial ultrasound improves functional outcomes in patients with severe acute ischemic stroke (NCT#01098981).
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Peter D. Schellinger, Andrei V. Alexandrov, Andrew D. Barreto, Andrew M. Demchuk, Georgios Tsivgoulis, Martin Kohrmann, John Alleman, Virginia Howard, George Howard, Anne W. Alexandrov, Gordon Brandt, Carlos A. Molina, Tags: Protocol Source Type: research

Carotid plaque inflammation assessed with 18F‐FDG PET/CT is higher in symptomatic compared with asymptomatic patients
Conclusion18F‐FDG uptake on PET/CT correlated with histological assessments of inflammation and was higher in patients with symptomatic compared with asymptomatic carotid artery plaques. These results support the use of 18F‐FDG PET/CT in the detection inflammation in carotid atherosclerosis, which may be of help in the detection of vulnerable plaques.
Source: International Journal of Stroke - January 15, 2015 Category: Neurology Authors: Karolina Skagen, Kjersti Johnsrud, Kristin Evensen, Helge Scott, Kirsten Krohg‐Sørensen, Frode Reier‐Nilsen, Mona‐Elisabeth Revheim, Jan Gunnar Fjeld, Mona Skjelland, David Russell Tags: Research Source Type: research

Cerebrovascular ultrasound as a first method of detecting aortic dissection in acute stroke patients
Source: International Journal of Stroke - December 10, 2014 Category: Neurology Authors: E. Vassileva, M. G. Klissurski, E. V. Vavrek, M. P. Daskalov Tags: Letter to the editor Source Type: research

Carotid ultrasound imaging in a patient with acute ischemic stroke and aortic dissection: a lesson for the management of ischemic stroke?
Source: International Journal of Stroke - November 25, 2013 Category: Neurology Authors: N. Morelli, E. Rota, M. Mancuso, P. Immovilli, M. Spallazzi, G. Rocca, E. Michieletti, D. Guidetti Tags: Letter to the editor Source Type: research

Carotid intima‐media thickness – a potential predictor for rupture risk of intracranial aneurysms
ConclusionThere is an association between IMT and intracranial aneurysm rupture status at the time of aneurysm treatment. Carotid IMT can be a potential predictor of aneurysm rupture. IMT may thus be a possible adjunct in the risk assessment of aneurysm rupture, and a helpful tool in patient risk stratification and counseling.
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: Marianne Lundervik, Annette Fromm, Øystein Ariansen Haaland, Ulrike Waje‐Andreassen, Frode Svendsen, Lars Thomassen, Christian A. Helland Tags: Research Source Type: research

Potential of magnetic resonance‐guided focused ultrasound for intracranial hemorrhage: an in vitro feasibility study
ConclusionsThese results demonstrate the feasibility of obtaining reproducible, rapid, efficient, and accurate blood clot lysis using the magnetic resonance‐guided focused ultrasound system. Further in vivo studies are needed to validate the feasibility of magnetic resonance‐guided focused ultrasound as a treatment modality for intracranial hemorrhage.
Source: International Journal of Stroke - June 27, 2013 Category: Neurology Authors: Sagi Harnof, Arik Hananel, Iris Kulbatski, Moshe Hadani, Neal Kassell Tags: Research Source Type: research