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Source: International Journal of Stroke
Condition: Atrial Fibrillation

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Total 30 results found since Jan 2013.

Posterior vs. anterior circulation infarction: demography, outcomes, and frequency of hemorrhage after thrombolysis
ConclusionsOur study suggests that posterior circulation stroke is associated with a lower risk of intracranial hemorrhage than anterior circulation stroke is.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Tomáš Dorňák, Michal Král, Martin Hazlinger, Roman Herzig, Tomáš Veverka, Stanislav Buřval, Daniel Šaňák, Jana Zapletalová, Kristýna Antalíková, Petr Kaňovský Tags: Research Source Type: research

The Clinical Relevance of Microbleeds in Stroke study (CROMIS‐2): rationale, design, and methods
Background and rationaleThe increasing use of oral anticoagulants, mostly to prevent ischemic stroke due to atrial fibrillation in an ageing population, has been associated with a fivefold increased incidence of oral anticoagulant‐associated intracerebral hemorrhage: a rare, serious, and unpredictable complication. We hypothesize that cerebral microbleeds and other markers of cerebral small vessel disease on magnetic resonance imaging, and genetic polymorphisms (e.g. influencing cerebral small vessel integrity or anticoagulation stability), are associated with an increased risk of oral anticoagulant‐associated intracer...
Source: International Journal of Stroke - August 2, 2015 Category: Neurology Authors: Andreas Charidimou, Duncan Wilson, Clare Shakeshaft, Gareth Ambler, Mark White, Hannah Cohen, Tarek Yousry, Rustam Al‐Shahi Salman, Gregory Lip, Henry Houlden, Hans R. Jäger, Martin M. Brown, David J. Werring Tags: Protocol Source Type: research

Very short paroxysms account for more than half of the cases of atrial fibrillation detected after stroke and TIA: a systematic review and meta‐analysis
ConclusionsThe clinical and prognostic significance of poststroke atrial fibrillation episodes shorter than 30 s is unknown. The high frequency of poststroke atrial fibrillation episodes shorter than 30 s justify further investigation into the risk of stroke recurrence and the risk–benefit profile of anticoagulation for this patient population.
Source: International Journal of Stroke - July 6, 2015 Category: Neurology Authors: Luciano A. Sposato, Lauren E. Cipriano, Patricia M. Riccio, Vladimir Hachinski, Gustavo Saposnik Tags: Systematic review Source Type: research

Improved ischemic stroke outcome prediction using model estimation of outcome probability: The THRIVE‐c calculation
ConclusionBy computing the logistic equation with patient‐specific continuous variables in the THRIVE‐c calculation, outcomes at the individual patient level are more accurately estimated. Given the widespread availability of computers and devices at the point of care, such calculations can be easily performed with a simple user interface.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Alexander C. Flint, Vivek A. Rao, Sheila L. Chan, Sean P. Cullen, Bonnie S. Faigeles, Wade S. Smith, Philip M. Bath, Nils Wahlgren, Niaz Ahmed, Geoff A. Donnan, S. Claiborne Johnston, Tags: Research Source Type: research

Risk factors for ischemic stroke and its subtypes in Chinese vs. Caucasians: Systematic review and meta‐analysis
ConclusionOur study showed a lower prevalence of atrial fibrillation, ischemic heart disease and hypercholesterolemia in Chinese, and mostly similar risk factor associations in Chinese and Caucasian ischemic stroke patients. Further analyses of individual patient data to allow adjustment for confounders are needed to confirm and extend these findings.
Source: International Journal of Stroke - April 23, 2015 Category: Neurology Authors: Chung‐Fen Tsai, Niall Anderson, Brenda Thomas, Cathie L. M. Sudlow Tags: Systematic Review Source Type: research

Antithrombotic treatment at onset of stroke with atrial fibrillation, functional outcome, and fatality: a systematic review and meta‐analysis
ConclusionsTherapeutic International Normalized Ratio at stroke onset was associated with early and late improved survival and functional recovery suggesting sustained benefit for warfarin anticoagulation for stroke outcome in atrial fibrillation patients. Long‐term outcome data following stroke in patients taking new oral anticoagulants is required.
Source: International Journal of Stroke - March 22, 2015 Category: Neurology Authors: Niamh Hannon, Ethem M. Arsava, Heinrich J. Audebert, Hakan Ay, Morgan Crowe, Danielle Ní Chróinín, Karen Furie, Catherine McGorrian, Noa Molshatzki, Sean Murphy, Imelda Noone, Martin O'Donnell, Johannes Schenkel, Kit M. Tan, David Tanne, Peter J. Kelly Tags: Research Source Type: research

Trends in oral anticoagulant choice for acute stroke patients with nonvalvular atrial fibrillation in Japan: The SAMURAI‐NVAF Study
ConclusionsWarfarin use at acute hospital discharge was still common in the initial years after approval of nonvitamin K antagonist oral anticoagulants, although nonvitamin K antagonist oral anticoagulant users increased gradually. The index stroke was milder and ischemia‐risk indices were lower in nonvitamin K antagonist oral anticoagulant users than in warfarin users. Early initiation of nonvitamin K antagonist oral anticoagulants seemed safe.
Source: International Journal of Stroke - January 12, 2015 Category: Neurology Authors: Kazunori Toyoda, Shoji Arihiro, Kenichi Todo, Hiroshi Yamagami, Kazumi Kimura, Eisuke Furui, Tadashi Terasaki, Yoshiaki Shiokawa, Kenji Kamiyama, Shunya Takizawa, Satoshi Okuda, Yasushi Okada, Tomoaki Kameda, Yoshinari Nagakane, Yasuhiro Hasegawa, Hiroshi Tags: Research Source Type: research

Canadian Stroke Best Practice Recommendations: secondary prevention of stroke guidelines, update 2014
Every year, approximately 62 000 people with stroke and transient ischemic attack are treated in Canadian hospitals. The 2014 update of the Canadian Secondary Prevention of Stroke guideline is a comprehensive summary of current evidence‐based recommendations for clinicians in a range of settings, who provide care to patients following stroke. Notable changes in this 5th edition include an emphasis on treating the highest risk patients who present within 48 h of symptom onset with transient or persistent motor or speech symptoms, who need to be transported to the closest emergency department with capacity for advanced...
Source: International Journal of Stroke - December 23, 2014 Category: Neurology Authors: Shelagh B. Coutts, Theodore H. Wein, M. Patrice Lindsay, Brian Buck, Robert Cote, Paul Ellis, Norine Foley, Michael D. Hill, Sharon Jaspers, Albert Y. Jin, Brenda Kwiatkowski, Carolyn MacPhail, Dana McNamara‐Morse, Michael S. McMurtry, Tania Mysak, Andr Tags: Guidelines Source Type: research

Effect of addition of clopidogrel to aspirin on subdural hematoma: meta‐analysis of randomized clinical trials
ConclusionsThe absolute rate of subdural hematoma during dual antiplatelet therapy is low, averaging 1·1 per 1000 patient‐years. Chronic treatment with clopidogrel plus aspirin significantly increases the risk of subdural hematoma compared with aspirin alone.
Source: International Journal of Stroke - December 1, 2014 Category: Neurology Authors: Majid F. Bakheet, Lesly A. Pearce, Robert G. Hart Tags: Research Source Type: research

Anemia on admission predicts short‐ and long‐term outcomes in patients with acute ischemic stroke
ConclusionAnemia is common among AIS patients and is associated with cardiovascular comorbidities. Low hemoglobin status independently predicts short and long‐term mortality.
Source: International Journal of Stroke - November 27, 2014 Category: Neurology Authors: Haralampos Milionis, Vasileios Papavasileiou, Ashraf Eskandari, Suzette D'Ambrogio‐Remillard, George Ntaios, Patrik Michel Tags: Research Source Type: research

Rationale and design of Triple AXEL: trial for early anticoagulation in acute ischemic stroke patients with nonvalvular atrial fibrillation
DiscussionThe results of this proof‐of‐concept trial will guide go/no‐go decision to a large phase 3 confirmatory trial.
Source: International Journal of Stroke - October 26, 2014 Category: Neurology Authors: Keun‐Sik Hong, Yun Jung Choi, Sun U. Kwon, Tags: Protocols Source Type: research

Burden of stroke in Puerto Rico
Stroke is the fifth leading cause of death and the first cause of long‐term disability in Puerto Rico. Trained staff reviewed and independently validated the medical records of patients who had been hospitalized with possible stroke at any of the 20 largest hospitals located in Puerto Rico during 2007, 2009, and 2011. The mean age of the 5005 newly diagnosed stroke patients (51·2% female) was 70 years. At the time of hospitalization, women were 4½ years older, were less likely to be married (60·2% vs. 39·9%, P < 0·001), smoked less (5·8% vs. 13·4%, P < 0·001), and had significantly higher proportion...
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: J. C. Zevallos, F. Santiago, J. González, A. Rodríguez, L. Pericchi, R. Rodríguez‐Mercado, U. Nobo Tags: Panorama Source Type: research

Hypothermia and atrial fibrillation
Source: International Journal of Stroke - June 9, 2014 Category: Neurology Authors: Geoffrey A. Donnan Tags: Editorial Source Type: research

Management of acute stroke in patients taking novel oral anticoagulants
Each year, 1·0–2·0% of individuals with atrial fibrillation and 0·1–0·2% of those with venous thromboembolism who are receiving one of the novel oral anticoagulants (dabigatran, rivaroxaban, or apixaban) can be expected to experience an acute ischemic stroke. Additionally, 0·2–0·5% of individuals with atrial fibrillation who are receiving one of the novel oral anticoagulants can be expected to experience an intracranial hemorrhage. This opinion piece addresses the current literature and offers practical approaches to the management of patients receiving novel oral anticoagulants who present with an ischemic or ...
Source: International Journal of Stroke - June 1, 2014 Category: Neurology Authors: Graeme J. Hankey, Bo Norrving, Werner Hacke, Thorsten Steiner Tags: Review Source Type: research

Prescription frequency and predictors for the use of novel direct oral anticoagulants for secondary stroke prevention in the first year after their marketing in Europe – a multicentric evaluation
ConclusionsShortly after their marketing, DOAC are used as frequently as VKA for secondary stroke prevention in patients with atrial fibrillation. The decision between VKA and DOAC is mainly determined by the patient's renal function and the absence or presence of prior oral anticoagulant therapy.
Source: International Journal of Stroke - May 15, 2014 Category: Neurology Authors: Sebastian Luger, Carina Hohmann, Peter Kraft, Ramona Halmer, Ignaz Gunreben, Tobias Neumann‐Haefelin, Christoph Kleinschnitz, Silke Walter, Veronika Haripyan, Helmuth Steinmetz, Christian Foerch, Waltraud Pfeilschifter Tags: Research Source Type: research