• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Factors for short-term outcomes in patients with a minor stroke: results from China National Stroke Registry
In this study, we aimed to identify which factors were associated with adverse outcomes of a minor stroke. Methods: The China National Stroke Registry (CNSR) is a nationwide prospective registry for patients presented to hospitals with acute cerebrovascular events between September 2007 and August 2008. The 3-month follow-up was completed in 4669 patients with a minor stroke defined as the initial neurological severity lower than 4 in the National Institutes of Health Stroke Scale (NIHSS). Multivariate model was used to determine the association between risk factors and clinical outcomes. Results: Of 4669 patients with a m...
Source: BMC Neurology - December 9, 2015 Category: Neurology Authors: Lingyun WuAnxin WangXianwei WangXingquan ZhaoChunxue WangLiping LiuHuaguang ZhengYongjun WangYibin CaoYilong Wangon behalf of the China National Stroke Registry investigators Source Type: research

Treatment of Rivaroxaban versus Aspirin for Non-disabling Cerebrovascular Events (TRACE): study protocol for a randomized controlled trial
DiscussionEven though the new oral anticoagulants seem to be both safe and effective, few clinical trials have been carried out to test their effect on non-disabling cerebrovascular events. Treatment with rivaroxaban may prevent more cerebrovascular events with an acceptable risk profile after TIA or minor stroke, compared with aspirin, thus helping to improve the outcome of the disease.Trial registrationNo. NCT01923818
Source: BMC Neurology - October 12, 2015 Category: Neurology Authors: Fang YangWenrui JiangYa BaiJunliang HanXuedong LiuGuangyun ZhangGang Zhao Source Type: research

Successful recanalization post endovascular therapy is associated with a decreased risk of intracranial haemorrhage: a retrospective study
Background: The risks of intracranial haemorrhage (ICH) post intra-arterial therapy (IAT) for stroke are not well understood. We aimed to study the influence of recanalization status post IAT for anterior circulation stroke and posterior circulation stroke on ICH development. Methods: Retrospective analysis of 193 patients in a prospectively collected database of IAT stroke patients was performed. Successful recanalization was defined as a Thrombolysis in Cerebral Infarction Score of 2b or 3 and symptomatic ICH (SICH) as parenchymal hematoma type 2 (PH2) with neurological deterioration. The association between the recanali...
Source: BMC Neurology - October 7, 2015 Category: Neurology Authors: David WangLeonid ChurilovRichard DowlingPeter MitchellBernard Yan Source Type: research

Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study
Background: Experimental studies suggest that pre-stroke statin treatment has a dual effect of neuroprotection during ischemia and neurorestoration after ischemic injury. The aim of this study was to evaluate the effect of pre-stroke statin use on initial stroke severity and early clinical outcome. Methods: We used a prospective database enrolling patients with acute ischemic stroke from 12 hospitals in Korea between April 2008 and January 2012. Primary endpoint was the initial stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score. Secondary endpoints were good outcome (modified Rankin...
Source: BMC Neurology - July 30, 2015 Category: Neurology Authors: Jay ChoiJi LeeTai ParkYong-Jin ChoJong-Moo ParkKyusik KangKyung LeeSoo-Joo LeeYoungchai KoJun LeeJoon-Tae KimKyung-Ho YuByung-Chul LeeJae-Kwan ChaDae-Hyun KimJuneyoung LeeDong-Eog KimMyung JangBeom KimMoon-Ku HanHee-Joon BaeKeun-Sik Hong Source Type: research

Apathy and suicide-related ideation 3 months after stroke: a cross-sectional study
Background: Both apathy and suicide are common in poststroke patients. However, the association between poststroke apathy and suicide-related ideation (SI) in Chinese stroke patients is not clear and poorly understood. The aim of this study was to examine the association between apathy and SI in stroke. Methods: A cross-sectional study was conducted to investigate the association in 518 stroke survivors from Acute Stroke Unit of the Prince of Wales Hospital in Hong Kong. Geriatric Mental State Examination-Version A (GMS) and Neuropsychiatric Inventory-apathy subscale (NPI-apathy) were employed to assess poststroke SI and a...
Source: BMC Neurology - April 23, 2015 Category: Neurology Authors: Wai TangLara CaeiroChieh LauHuajun LiangVincent MokGabor UngvariKa Wong Source Type: research

Web-based tool for dynamic functional outcome after acute ischemic stroke and comparison with existing models
Background: Acute ischemic stroke (AIS) is one of the leading causes of death and adult disability worldwide. In the present study, we aimed to develop a web-based risk model for predicting dynamic functional status at discharge, 3-month, 6-month, and 1-year after acute ischemic stroke (Dynamic Functional Status after Acute Ischemic Stroke, DFS-AIS). Methods: The DFS-AIS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) and validation (40%) cohorts. Good functional outcome was defined as modified Rankin Scale (mRS) score???2 at discharge...
Source: BMC Neurology - November 25, 2014 Category: Neurology Authors: Ruijun JiWanliang DuHaipeng ShenYuesong PanPenglian WangGaifen LiuYilong WangHao LiXingquan ZhaoYongjun WangOn behalf of China National Stroke Registry (CNSR) investigators Source Type: research

Mechanisms, predictors and clinical impact of early neurological deterioration: the protocol of the Trondheim early neurological deterioration study
DiscussionStrengths and weaknesses of our approach, along with reasons for the methods chosen in this study are discussed.
Source: BMC Neurology - October 28, 2014 Category: Neurology Authors: Bernt HellebergHanne EllekjærGitta RohwederBent Indredavik Source Type: research

Study protocol: prediction of stroke associated infections by markers of autonomic control
DiscussionSince a general prophylactic antibiotic treatment after stroke is not recommended, results of this study could have essential implications for an early identification and hence, timely appropriate treating of stroke-induced infections.Trial registration: Pradiktoren fur die Sepsis - Pred Sep, German Clinical Trials Register: DRKS00003392.
Source: BMC Neurology - January 13, 2014 Category: Neurology Authors: Dirk BrämerHeike HoyerAlbrecht GüntherSamuel NowackFrank BrunkhorstOtto WitteDirk Hoyer Source Type: research

Gothenburg very early supported discharge study (GOTVED) NCT01622205: a block randomized trial with superiority design of very early supported discharge for patients with stroke
Background: Stroke is the disease with the highest costs for hospital care and also after discharge. Early supported discharge (ESD) has shown to be efficient and safe and the best results with well-organised discharge teams and patients with less severe strokes.The aim is to investigate if very early supported discharge (VESD) for stroke patients in need for on-going individualised rehabilitation at home is useful for the patient and cost effective. Methods: A randomized controlled trial comparing VESD with ordinary discharge. Inclusion criteria: confirmed stroke,>18 years of age, living within 30 min from the stroke unit...
Source: BMC Neurology - June 24, 2013 Category: Neurology Authors: Katharina SunnerhagenAnna DanielssonRafsten LenaAnn BjörkdahlÅsa AxelssonÅsa NordinCathrine PeterssonÅsa Lundgren-NilssonFröjd Karin Source Type: research