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Source: Physiological Reviews
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Total 29 results found since Jan 2013.
Human temperature regulation under heat stress in health, disease, and injury
Physiol Rev. 2022 Jun 9. doi: 10.1152/physrev.00047.2021. Online ahead of print.ABSTRACTThe human body constantly exchanges heat with the environment. Temperature regulation is a homeostatic feedback control system that ensures deep body temperature is maintained within narrow limits despite wide variations in environmental conditions and activity-related elevations in metabolic heat production. Extensive research has been performed to study the physiological regulation of deep body temperature. This review focuses on healthy and disordered human temperature regulation during heat stress. Central to this discussion is the ...
Source: Physiological Reviews - June 9, 2022 Category: Physiology Authors: Matthew N Cramer Daniel Gagnon Orlando Laitano Craig G Crandall Source Type: research
Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R3405.ABSTRACTThe choroid plexus (CP) is a small tissue located inside brain ventricles. It is responsible for the production of most of the cerebrospinal fluid (CSF); approximately 500 mL of CSF per day in the adult human [1, 2]. CSF production occurs as a net result of transcellular movement of salt and water, carried out by various cellular transporters. Ncbe is a sodium-coupled bicarbonate transporter located in the basolateral membrane of the choroid plexus epithelial (CPE) cells. It transports Na+ and HCO3 - into the cell in exchange for Cl- . Ncbe is the m...
Source: Physiological Reviews - May 13, 2022 Category: Physiology Authors: Laura Ø Johnsen Kathrine A Friis Laura B Ry ø Jacob G Mikkelsen Thomas B Lindhardt Rasmus W Knopper Brian Hansen Jeppe Praetorius Helle H Damkier Source Type: research
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection
Physiol Rev. 2022 Mar 28. doi: 10.1152/physrev.00017.2021. Online ahead of print.ABSTRACTAging is the single largest risk factor for many debilitating conditions, including heart diseases, stroke, cancer, diabetes, and neurodegenerative disorders. While far from understood in its full complexity, it is scientifically well-established that aging is influenced by genetic and environmental factors, and can be modulated by various interventions. One of aging's early hallmarks are aberrations in transcriptional networks, controlling for example metabolic homeostasis or the response to stress. Evidence in different model organis...
Source: Physiological Reviews - March 28, 2022 Category: Physiology Authors: Fabian Fischer Giovanna Grigolon Christoph Benner Michael Ristow Source Type: research
Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies
Annu Rev Physiol. 2021 Oct 26. doi: 10.1146/annurev-physiol-060821-014521. Online ahead of print.ABSTRACTCerebral small vessel disease (SVD) is highly prevalent and a common cause of ischemic and hemorrhagic stroke and dementia, yet the pathophysiology is poorly understood. Its clinical expression is highly varied, and prognostic implications are frequently overlooked in clinics; thus, treatment is currently confined to vascular risk factor management. Traditionally, SVD is considered the small vessel equivalent of large artery stroke (occlusion, rupture), but data emerging from human neuroimaging and genetic studies refut...
Source: Physiological Reviews - October 26, 2021 Category: Physiology Authors: Joanna M Wardlaw Helene Benveniste Anna Williams Source Type: research
