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Brain study paves way for therapy for common cause of dementia
(University of Edinburgh) Scientists at the University of Edinburgh have uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people. Studies with rats found the treatment can reverse changes in blood vessels in the brain associated with the condition, called cerebral small vessel disease. Treatment also prevents damage to brain cells caused by these blood vessel changes, raising hope that it could offer a therapy for dementia.
Source: EurekAlert! - Medicine and Health - July 4, 2018 Category: International Medicine & Public Health Source Type: news

AcuraStem receives fast-track SBIR grant
(AcuraStem, Inc.) AcuraStem, a fast-growing and innovative biotech company located in Monrovia, California, has been awarded a 3.7 million dollar Small Business Innovation Research (SBIR) Fast-Track grant (#R44NS105156) by the National Institute of Neurological Disorders and Stroke (NINDS) to continue research for the development of a small molecule therapeutic, 'AS2015', focused on treating patients with the genetic form of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by expansion repeats in the gene C9ORF72.
Source: EurekAlert! - Medicine and Health - June 18, 2018 Category: International Medicine & Public Health Source Type: news

Stroke prevention drugs may help reduce dementia risk for atrial fibrillation patients
(European Society of Cardiology) Patients with atrial fibrillation could reduce the risk of dementia by taking stroke prevention medications, according to recommendations published online today in EP Europace1, a European Society of Cardiology journal, and presented at EHRA 2018.2 The international consensus document was also published in HeartRhythm, the official journal of the Heart Rhythm Society (HRS), and Journal of Arrhythmia, the official journal of the Japanese Heart Rhythm Society (JHRS) and the Asia Pacific Heart Rhythm Society (APHRS).
Source: EurekAlert! - Medicine and Health - March 18, 2018 Category: International Medicine & Public Health Source Type: news

CRISPR helps find new genetic suspects behind ALS/FTD
(NIH/National Institute of Neurological Disorders and Stroke) NIH-funded researchers used the gene editing tool CRISPR to rapidly identify genes in the human genome that might modify the severity of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by mutations in a gene called C9orf72. The results of the search uncovered a new set of genes that may hasten neuron death during the disease.
Source: EurekAlert! - Medicine and Health - March 12, 2018 Category: International Medicine & Public Health Source Type: news

Worldwide study triples number of known genetic risk factors for stroke
(University of Texas Health Science Center at San Antonio) The largest genetic study of stroke to date triples the number of known genetic risk factors for the disease and also should enable researchers to find novel treatments for dementia. The study team included Sudha Seshadri, M.D., of the Glenn Biggs Institute for Alzheimer's& Neurodegenerative Diseases at UT Health San Antonio.
Source: EurekAlert! - Medicine and Health - March 12, 2018 Category: International Medicine & Public Health Source Type: news

UA study: Brain liquefaction after stroke is toxic to surviving brain
(University of Arizona Health Sciences) Researchers at the University of Arizona College of Medicine-Tucson suggest liquefied brain fluid may be one cause of dementia after stroke.
Source: EurekAlert! - Medicine and Health - February 20, 2018 Category: International Medicine & Public Health Source Type: news

MIND diet may slow cognitive decline in stroke survivors
(Rush University Medical Center) A diet created by researchers at Rush University Medical Center may help substantially slow cognitive decline in stroke survivors, according to preliminary research presented on Jan. 25, at the American Stroke Association's International Stroke Conference 2018 in Los Angeles. The finding are significant because stroke survivors are twice as likely to develop dementia compared to the general population.
Source: EurekAlert! - Medicine and Health - January 25, 2018 Category: International Medicine & Public Health Source Type: news

Neurosexuality needs to be better addressed in patients with neurodisabilities
(IOS Press) For people with brain disorders, whether from injury or disease, rehabilitation is a complex process. Neurosexuality is an emerging area of study and practice that focuses on the relationships between brain and sexual function in individuals with and without neurological disorders. Experts on the subject, reporting in NeuroRehabilitation, discuss how sexuality can affect neurorehabilitation in patients suffering from a range of conditions, from stroke and spinal cord injuries to sexual behavior in patients with dementia.
Source: EurekAlert! - Medicine and Health - December 20, 2017 Category: International Medicine & Public Health Source Type: news

Increased risk of vascular dementia in heart attack survivors
(Aarhus University) It is well known that vascular dementia is triggered by factors such as stroke, but an extensive study from Aarhus University, Denmark, now shows that heart attack also is associated with increased risk -- by 35 per cent, in fact.According to Jens Sundb ø ll, who is behind the study, this can be an argument for more intensive preventive efforts.
Source: EurekAlert! - Medicine and Health - November 13, 2017 Category: International Medicine & Public Health Source Type: news

Predicting cognitive deficits in people with Parkinson's disease
(NIH/National Institute of Neurological Disorders and Stroke) Parkinson's disease is commonly thought of as a movement disorder, but after years of living with the disease, approximately 25 percent of patients also experience deficits in cognition that impair function. A newly developed research tool may help predict a patient's risk for developing dementia and could enable clinical trials aimed at finding treatments to prevent the cognitive effects of the disease.
Source: EurekAlert! - Medicine and Health - June 21, 2017 Category: International Medicine & Public Health Source Type: news

Scripps Florida scientist and collaborators win $7 million grant to develop new ALS treatments
(Scripps Research Institute) Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute (TSRI), together with scientists from Mayo Clinic's Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).
Source: EurekAlert! - Medicine and Health - June 15, 2017 Category: International Medicine & Public Health Source Type: news

Stroke prevention may also reduce dementia
(University of Western Ontario) Ontario's stroke prevention strategy appears to have had an unexpected, beneficial side effect: a reduction also in the incidence of dementia among older seniors. A new paper by researchers at Western University and Lawson Health Research Institute is the first to look at the demographics of both stroke and dementia across Ontario since the province pioneered Canada's first stroke prevention strategy in 2000.
Source: EurekAlert! - Medicine and Health - May 1, 2017 Category: Global & Universal Source Type: news

Is soda bad for your brain? (and is diet soda worse?)
(Boston University) New research suggests that excess sugar -- especially the fructose in sugary drinks -- might damage your brain. Researchers at Boston University found that people who drink sugary beverages frequently are more likely to have poorer memory, smaller overall brain volume, and a significantly smaller hippocampus. A follow-up study found that people who drank diet soda daily were almost three times as likely to develop stroke and dementia when compared to those who did not.
Source: EurekAlert! - Medicine and Health - April 20, 2017 Category: Global & Universal Source Type: news

Cerebrovascular disease linked to Alzheimer's
(Rush University Medical Center) While strokes are known to increase risk for dementia, much less is known about diseases of large and small blood vessels in the brain, separate from stroke, and how they relate to dementia. Diseased blood vessels in the brain itself, which commonly is found in elderly people, may contribute more significantly to Alzheimer's disease dementia than was previously believed, according to new study results published in June in The Lancet Neurology, a British medical journal.
Source: EurekAlert! - Medicine and Health - July 1, 2016 Category: Global & Universal Source Type: news

Scientists create mice with a major genetic cause of ALS and FTD
(NIH/National Institute of Neurological Disorders and Stroke) Scientists at Mayo Clinic, Jacksonville, Fla., created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a mutation in the a gene called C9ORF72.
Source: EurekAlert! - Medicine and Health - May 22, 2015 Category: Global & Universal Source Type: news

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