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Error in USPSTF Report on Statin Use
The 2016 review for the US Preventive Services Task Force on statins for prevention of cardiovascular disease in adults had errors in the analysis of statins vs placebo and cardiovascular mortality. For the JUPITER trial, we interpreted “MI, stroke or cardiovascular death” as reported in the main trial publication as “myocardial death, stroke death, or cardiovascular death,” when it meant “nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death.” Therefore, the analysis erroneously included nonfatal myo cardial infarction and stroke events (83/8901 vs 157/8901 in the rosuvastatin vs placebo gro...
Source: JAMA - February 18, 2020 Category: General Medicine Source Type: research

Adverse Effects of Statins
In Reply Dr Goldstein questions the relationship between cholesterol levels, statins, and hemorrhagic stroke. Evidence for the association between low –total serum cholesterol levels, which is mostly LDL-C, and an increased risk of hemorrhagic stroke has been available since at least the late 1980s. A meta-analysis of 23 studies including 1.4 million participants and 7960 hemorrhagic strokes found that the RR of hemorrhagic stroke was 38% higher (95% CI, 8%-59%) in patients with the highest vs lowest LDL-C values. The Cholesterol Treatment Trialists’ Collaboration meta-analysis of 26 trials showed a nonsignificant incr...
Source: JAMA - March 14, 2017 Category: Journals (General) Source Type: research