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Source: JAMA
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Use of Oral Anticoagulants and Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke
To the Editor A recent study examined the safety of intravenous alteplase in patients taking NOACs within 7 days of acute ischemic stroke. Although the authors paired GWTG-Stroke registry data with data from the ARAMIS registry, the time of last NOAC dose was known in only 2% of patients in this study. Moreover, patients taking NOACs within 48 hours of intravenous alteplase experienced a higher rate of symptomatic intracranial hemorrhage compared with the overall NOAC population (8% vs 3.7%), suggesting that alteplase should be avoided within 48 hours of NOAC administration until more comprehensive data are available. A re...
Source: JAMA - June 21, 2022 Category: General Medicine Source Type: research
