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Source: Heart
Condition: Heart Attack

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Total 79 results found since Jan 2013.

Red cell distribution width in relation to incidence of coronary events and case fatality rates: a population-based cohort study
Conclusions In this population-based study of subjects without history of CE or stroke, high RDW was associated with increased incidence of fatal CE. No relationship was observed for incidence of non-fatal CE.
Source: Heart - June 21, 2014 Category: Cardiology Authors: Borne, Y., Smith, J. G., Melander, O., Engstrom, G. Tags: Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Coronary artery disease Source Type: research

Cardiovascular highlights from non-cardiology journals
Warfarin for atrial fibrillation in patients with chronic kidney disease – does the thromboembolic benefit outweigh the bleeding risk? Chronic kidney disease (CKD) predisposes to high risks for both thrombo-embolism and bleeding. As a result, understanding the risk-benefit profile for use of anticoagulation therapies among CKD patients with atrial fibrillation is important to optimize patient outcomes. However, clinical trials evaluating efficacy and safety of anti-coagulants for atrial fibrillation generally exclude CKD patients and observational studies have had conflicting results. Accordingly, this prospective co...
Source: Heart - June 9, 2014 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Heartbeat: Highlights from the issue
In this issue of Heart, Dr. Bouri and colleagues (see page 456) reexamined the issue of the perioperative use of beta blockers in patients with an intermediate or high cardiovascular risk who are undergoing major non cardiac surgery. Unfortunately, the evidence base for current recommendations has been called into question because of allegations of research fraud in some of the main studies, which are excluded from this new meta-analysis of the relevant randomized controlled clinical trials. They found that although beta-blockers decreased the risk of non-fatal myocardial infarction, they increased the risk of stroke and h...
Source: Heart - February 19, 2014 Category: Cardiology Authors: Otto, C. M. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Epidemiology Heartbeat Source Type: research

Meta-analysis of secure randomised controlled trials of {beta}-blockade to prevent perioperative death in non-cardiac surgery
Conclusions Guideline bodies should retract their recommendations based on fictitious data without further delay. This should not be blocked by dispute over allocation of blame. The well-conducted trials indicate a statistically significant 27% increase in mortality from the initiation of perioperative β-blockade that guidelines currently recommend. Any remaining enthusiasts might best channel their energy into a further randomised trial which should be designed carefully and conducted honestly.
Source: Heart - February 19, 2014 Category: Cardiology Authors: Bouri, S., Shun-Shin, M. J., Cole, G. D., Mayet, J., Francis, D. P. Tags: Open access, Drugs: cardiovascular system, Echocardiography, Interventional cardiology, Acute coronary syndromes, Clinical diagnostic tests, Epidemiology Cardiac risk factors and prevention Source Type: research

Ethnicity and prediction of cardiovascular disease: performance of QRISK2 and Framingham scores in a UK tri-ethnic prospective cohort study (SABRE--Southall And Brent REvisited)
Conclusions Neither score performed consistently well in all ethnic groups. Further validation of QRISK2 in other multi-ethnic datasets, and better methods for identifying high risk African Caribbeans and South Asian women, are required.
Source: Heart - December 6, 2013 Category: Cardiology Authors: Tillin, T., Hughes, A. D., Whincup, P., Mayet, J., Sattar, N., McKeigue, P. M., Chaturvedi, N., On behalf of the SABRE Study Group, Chaturvedi, Baker, Beauchamp, Coady, Collins, Forouhi, Gedroyc, Godsland, Hattersley, Heasman, Hughes, Key, Majeed, March, Tags: Open access, Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Source Type: research

Cardiovascular highlights from non-cardiology journals
This study included randomised trials of drugs to lower blood pressure that were compared with placebo or other drugs with at least 1000 patient years of follow-up in each treatment arm. The primary outcome was major CV events (the composite of stroke, myocardial infarction, heart failure or CV death), with secondary outcomes of each element of the composite outcome as well as all-cause mortality. These 26 trials included 152 290 patients, of which 30 295 had impaired renal function (estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2). Meta-analysis according to baseline kidney fu...
Source: Heart - December 6, 2013 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

The positive predictive value of ct-proAVP (copeptin) in patients with STEMI
Recently Reinstadler et al reported on a study in n=54 patients diagnosed with STEMI who underwent copeptin sampling 2 (1–3) days after the index event and Cardiac Magnetic Resonance (CMR) on the same day. A follow-up CMR study was done after 4 months in n=47 patients. The authors found a strong and significant correlation between day 2 copeptin and ejection fraction, end systolic volume, stroke volume and per cent infarct mass. Additionally, using optimised cutoffs, adverse remodelling could be excluded by the combination of copeptin with NT-proBNP.1 Copeptin is a stable glycopeptide comprising the C-terminal p...
Source: Heart - September 20, 2013 Category: Cardiology Authors: Mockel, M., Searle, J. Tags: Drugs: cardiovascular system, Hypertension, Interventional cardiology, Acute coronary syndromes, Clinical diagnostic tests Editorials Source Type: research

Recent advances in the epidemiology, outcome, and prevention of myocardial infarction and stroke in sub-Saharan Africa
The early part of the new millennium witnessed reports of a growing burden of cardiovascular disease in Sub-Saharan Africa (SSA). However the contribution of ischemic heart disease and stroke to this increasing burden relative to that caused by hypertensive heart disease, cardiomyopathy and rheumatic heart disease was not clear. Over the last decade, data from the continent has begun to clarify this issue and suggests three main points. The burden of ischemic heart disease relative to other causes of heart disease remains low particularly in the black Africans majority. Stroke caused predominantly by hypertension is now a ...
Source: Heart - August 2, 2013 Category: Cardiology Authors: Ntsekhe, M., Damasceno, A. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Global burden of cardiovascular disease Source Type: research

Bilateral internal mammary artery bypass grafting: long-term clinical benefits in a series of 1000 patients
Conclusions Our longitudinal analysis presents encouraging data concerning operative risk of BIMA grafting and provides excellent long-term survival in appropriately selected patients.
Source: Heart - May 13, 2013 Category: Cardiology Authors: Popovic, B., Voillot, D., Maureira, P., Vanhuyse, F., Agrinier, N., Aliot, E., Folliguet, T., Villemot, J. P. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Epidemiology Cardiovascular surgery Source Type: research

Development and validation of a prediction rule for recurrent vascular events based on a cohort study of patients with arterial disease: the SMART risk score
Conclusions Patients at high risk for recurrent vascular events can be identified based on readily available clinical characteristics.
Source: Heart - May 13, 2013 Category: Cardiology Authors: Dorresteijn, J. A. N., Visseren, F. L. J., Wassink, A. M. J., Gondrie, M. J. A., Steyerberg, E. W., Ridker, P. M., Cook, N. R., van der Graaf, Y., on behalf of the SMART Study Group, Algra, Grobbee, Rutten, Moll, Kappelle, Mali, Doevendans Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Clinical diagnostic tests, Epidemiology, Tobacco use Prognosis research Source Type: research

Incidence, cardiovascular complications and mortality of hypertension by sex and ethnicity
Conclusions South Asian patients had higher rates of hypertension compared to the other ethnic groups. South Asian and Chinese patients had a lower risk of death and developing cardiovascular outcomes compared to whites. Women with hypertension have a better prognosis than men regardless of ethnicity.
Source: Heart - April 18, 2013 Category: Cardiology Authors: Quan, H., Chen, G., Walker, R. L., Wielgosz, A., Dai, S., Tu, K., Campbell, N. R. C., Hemmelgarn, B. R., Hill, M. D., Johansen, H., McAlister, F. A., Khan, N., for Hypertension Outcome and Surveillance Team Tags: Hypertension, Editor's choice, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Source Type: research

Methods of accelerated atherosclerosis in diabetic patients
This article will focus on the effect of diabetes on the initiation and progression of arterial occlusive disease, preceded by a short outline of the enormous impact of this issue from a societal-economic perspective. Diabetes, a major healthcare issue The prevalence and associated costs of diabetes are expected to increase significantly. There are currently over 240...
Source: Heart - April 18, 2013 Category: Cardiology Authors: Pasterkamp, G. Tags: Diabetic heart disease, Health policy, Education in Heart, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology, Diabetes, Metabolic disorders Source Type: research

Blood pressure targets in patients with coronary artery disease: observations from traditional and Bayesian random effects meta-analysis of randomised trials
Conclusions The present body of evidence suggests that in patients with CAD, intensive systolic BP control to ≤135 mm Hg and possibly to ≤130 mm Hg is associated with a modest reduction in stroke and heart failure but at the expense of hypotension. Lower was better, although not consistently so for myocardial infarction, stroke, heart failure and perhaps angina. Further trials are needed to prove these findings.
Source: Heart - April 5, 2013 Category: Cardiology Authors: Bangalore, S., Kumar, S., Volodarskiy, A., Messerli, F. H. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology Systematic review Source Type: research