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Source: Heart
Condition: Heart Attack

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Total 79 results found since Jan 2013.

Sex-specific differences in adverse outcome events among patients with atrial fibrillation
Conclusion In this large study of patients with established AF, women had a lower risk of death than men, but there were no sex-specific differences in other adverse outcomes.
Source: Heart - August 25, 2022 Category: Cardiology Authors: Evers-Dörpfeld, S., Aeschbacher, S., Hennings, E., Eken, C., Coslovsky, M., Rodondi, N., Beer, J. H., Moschovitis, G., Ammann, P., Kobza, R., Ceylan, S., Krempke, M., Meyer-Zürn, C. S., Moutzouri, E., Springer, A., Sticherling, C., Bonati, Tags: Arrhythmias and sudden death Source Type: research

BMJ Rapid Recommendations on use of proprotein convertase subtilisin/kexin 9 inhibitors and ezetimibe to reduce cardiovascular risk
The new BMJ Rapid Recommendations addressed the following question: should we add another lipid-lowering drug in adults with low-density lipoprotein-cholesterol (LDL-C) over 1.8 mmol/L using a maximal dose of statins or intolerant to statins?1 Why is this question important? Both proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe have been shown to reduce LDL-C by approximately 60% and approximately 20%, respectively, and correspondingly may reduce major adverse cardiovascular events (MACE), including all-cause death, cardiovascular death, myocardial infarction (MI) and stroke. However, the bene...
Source: Heart - July 27, 2022 Category: Cardiology Authors: White, H. D. Tags: Editorials Source Type: research

Single direct oral anticoagulant therapy in stable patients with atrial fibrillation beyond 1 year after coronary stent implantation
Conclusions DOAC monotherapy showed similar efficacy in preventing ischaemic events and was associated with lower major bleeding events compared with combination therapy in patients with AF beyond 1 year after coronary stent implantation.
Source: Heart - January 28, 2022 Category: Cardiology Authors: Choi, Y., Lee, Y., Kim, S.-H., Kim, S., Kim, J. Y., Kim, T.-S., Hwang, Y., Kim, J.-H., Jang, S.-W., Lee, M. Y., Oh, Y.-S. Tags: Coronary artery disease Source Type: research

Heartbeat: sex disparities in stroke, heart failure and all-cause mortality in adults with coronary heart disease
Research on sex disparities in patients with coronary heart disease (CHD) largely has focused on events directly related to the coronary arteries themselves—recurrent myocardial infarction, revascularisation and cardiovascular death—rather than the wider consequences of atherosclerotic vascular disease. In contrast, Akyea and colleagues1 evaluated sex disparities across a broader range of major adverse cardiovascular events (MACE) including not only recurrent CHD, but also stroke, peripheral vascular disease, heart failure and all-cause mortality in a population-based cohort of 143 702 adults (median age 73 yea...
Source: Heart - December 10, 2021 Category: Cardiology Authors: Otto, C. M. Tags: Heartbeat Source Type: research

Sex disparity in subsequent outcomes in survivors of coronary heart disease
Conclusions After incident CHD, women have lower risk of composite MACE and recurrent CHD outcomes but higher risk of stroke, heart failure, and all-cause mortality compared with men.
Source: Heart - December 10, 2021 Category: Cardiology Authors: Akyea, R. K., Kontopantelis, E., Kai, J., Weng, S. F., Patel, R. S., Asselbergs, F. W., Qureshi, N. Tags: Editor's choice Coronary artery disease Source Type: research

Developing and validating a cardiovascular risk score for patients in the community with prior cardiovascular disease
Conclusions The PREDICT-CVD secondary prevention score uses routine measurements from clinical practice that enable it to be implemented in a primary care setting. The score will facilitate risk communication between primary care practitioners and patients with prior CVD, particularly as a resource to show the benefit of risk factor modification.
Source: Heart - May 31, 2017 Category: Cardiology Authors: Poppe, K. K., Doughty, R. N., Wells, S., Gentles, D., Hemingway, H., Jackson, R., Kerr, A. J. Tags: Cardiac risk factors and prevention Source Type: research

Long-term prognostic impact of left atrial volumes and emptying fraction in a community-based cohort
Conclusions In this community-based cohort, LAEF was a powerful predictor of incident cardiovascular events and its predictive ability was stronger than for LA volumes. Our findings suggest that LA dysfunction may represent a more advanced state of LA remodelling than LA enlargement.
Source: Heart - April 10, 2017 Category: Cardiology Authors: Hedberg, P., Selmeryd, J., Leppert, J., Henriksen, E. Tags: Drugs: cardiovascular system, Echocardiography, Acute coronary syndromes, Clinical diagnostic tests Heart failure and cardiomyopathies Source Type: research

Cardiovascular highlights from non-cardiology journals
Continuous positive airway pressure fails to improve cardiovascular outcomes in obstructive sleep apnea Obstructive sleep apnea (OSA) is associated with increased cardiovascular events in observational studies. Randomized trials have demonstrated continuous positive airway pressure (CPAP) therapy reduces blood pressure, markers of oxidative stress and insulin insensitivity. Yet, it remains unclear whether treatment with CPAP reduces cardiovascular events. In the largest study of its kind, 2717 patients aged 45 to 75 years with moderate-to-severe OSA and coronary or cerebrovascular disease were randomized in open-label fash...
Source: Heart - March 12, 2017 Category: Cardiology Authors: McCabe, J. M. Tags: Journal scan Source Type: research

Dipeptidyl peptidase-4 inhibitors and cardiovascular risks in patients with pre-existing heart failure
Conclusions In this nationwide T2DM cohort, the risks of mortality and the combination of MI and ischaemic stroke were lower for patients receiving DPP-4 inhibitors than for those who did not receive such treatment. DPP-4 inhibitor use was not associated with a higher risk of hospitalisation for HF even in patients with pre-existing HF.
Source: Heart - February 26, 2017 Category: Cardiology Authors: Ou, S.-M., Chen, H.-T., Kuo, S.-C., Chen, T.-J., Shih, C.-J., Chen, Y.-T. Tags: Health policy, Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology, Diabetes, Metabolic disorders Heart failure and cardiomyopathies Source Type: research

Coronary bypass surgery versus stenting in multivessel disease involving the proximal left anterior descending coronary artery
Conclusions In patients with multivessel disease with proximal LAD involvement, CABG is associated with lower rates of the safety composite endpoint of death, MI or stroke as compared with PCI with drug-eluting stents at 5 years of follow-up (number needed to treat=21). Trial registration number PRECOMBAT clinicaltrials.gov NCT00997828; SYNTAX: clinicaltrials.gov identifier: NCT00114972 NCT00114972.
Source: Heart - February 26, 2017 Category: Cardiology Authors: Cavalcante, R., Sotomi, Y., Zeng, Y., Lee, C. W., Ahn, J.-M., Collet, C., Tenekecioglu, E., Suwannasom, P., Onuma, Y., Park, S.-J., Serruys, P. W. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Percutaneous intervention, Epidemiology Coronary artery disease Source Type: research

Stop vasodepressor drugs in reflex syncope: a randomised controlled trial
Conclusions Recurrence of syncope and presyncope can be reduced by discontinuing/reducing vasoactive therapy in most elderly patients affected by reflex vasodepressor syncope. Trial registration number NCT01509534; EudraCT2013-004364-63; Results.
Source: Heart - February 26, 2017 Category: Cardiology Authors: Solari, D., Tesi, F., Unterhuber, M., Gaggioli, G., Ungar, A., Tomaino, M., Brignole, M. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Special populations Source Type: research

Pre-procedural dual antiplatelet therapy in patients undergoing transcatheter aortic valve implantation increases risk of bleeding
Conclusions The current study demonstrated that DAPT before TF-TAVI increased the risk of bleeding compared with single or no antiplatelet therapy. Lower intensity antiplatelet therapy was not associated with thrombotic events. In modern practice, it might be reasonable to perform TAVI using single or no pre-procedural antiplatelet therapy with an expectation of no increase of adverse events. Trial registration number UMIN-ID; 000020423; Results.
Source: Heart - February 15, 2017 Category: Cardiology Authors: Hioki, H., Watanabe, Y., Kozuma, K., Nara, Y., Kawashima, H., Kataoka, A., Yamamoto, M., Takagi, K., Araki, M., Tada, N., Shirai, S., Yamanaka, F., Hayashida, K., And on behalf of OCEAN-TAVI investigators Tags: Valvular heart disease Source Type: research

Perioperative outcomes of patients with hypertrophic cardiomyopathy undergoing non-cardiac surgery
Conclusions Patients with HCM undergoing high-risk and intermediate-risk non-cardiac surgeries have a low perioperative event rate, at an experienced centre. However, they have a higher risk of composite events versus matched patients without HCM.
Source: Heart - September 26, 2016 Category: Cardiology Authors: Dhillon, A., Khanna, A., Randhawa, M. S., Cywinski, J., Saager, L., Thamilarasan, M., Lever, H. M., Desai, M. Y. Tags: Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Heart failure, Acute coronary syndromes, Clinical diagnostic tests, Epidemiology Heart failure and cardiomyopathies Source Type: research

Cardiovascular events and all-cause mortality with insulin versus glucagon-like peptide-1 analogue in type 2 diabetes
Conclusions In this cohort of obese people with T2DM, intensification of dual oral therapy by adding GLP-1ar analogue is associated with a lower MACE outcome in routine clinical practice, compared with adding insulin therapy as the third glucose-lowering agent.
Source: Heart - September 12, 2016 Category: Cardiology Authors: Anyanwagu, U., Mamza, J., Mehta, R., Donnelly, R., Idris, I. Tags: Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology, Diabetes, Metabolic disorders Healthcare delivery, economics and global health Source Type: research

Contemporary evaluation and management of lower extremity peripheral artery disease
Peripheral artery disease (PAD) includes atherosclerosis of the aorta and lower extremities. Affecting a large segment of the population, PAD is associated with impaired functional capacity and reduced quality of life as well as an increased risk of stroke, myocardial infarction and cardiovascular death. The evaluation of PAD begins with the physical examination, incorporating non-invasive testing such as ankle-brachial indices to confirm the diagnosis. Therapeutic interventions are aimed at alleviating symptoms while preserving limb integrity and reducing overall cardiovascular risk. With this in mind, risk factor modific...
Source: Heart - August 23, 2016 Category: Cardiology Authors: Foley, T. R., Armstrong, E. J., Waldo, S. W. Tags: Review articles Reviews Source Type: research