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Source: European Heart Journal

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Total 332 results found since Jan 2013.

Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus
Patients with type 2 diabetes mellitus (T2D) exhibit an increased risk for cardiovascular (CV) events. Hyperglycaemia itself contributes to the pathogenesis of atherosclerosis and heart failure (HF) in these patients, but glucose-lowering strategies studied to date have had little to no impact on reducing CV risk, especially in patients with a long duration of T2D and prevalent CV disease (CVD). Sodium glucose cotransporter-2 (SGLT2) inhibitors are a novel class of anti-hyperglycaemic medications that increase urinary glucose excretion, thus improving glycaemic control independent of insulin. The recently published CV outc...
Source: European Heart Journal - November 16, 2016 Category: Cardiology Authors: Marx, N., McGuire, D. K. Tags: Clinical update Source Type: research

Comparison of the ATRIA, CHADS2, and CHA2DS2-VASc stroke risk scores in predicting ischaemic stroke in a large Swedish cohort of patients with atrial fibrillation
Conclusion In this SAF cohort, the ATRIA score predicted ischaemic stroke risk better than CHADS2 or CHA2DS2-VASc. However, relative performance of the categorical scores varied by population stroke rates. Score cut-points may need to be optimized to better fit local population stroke rates.
Source: European Heart Journal - November 16, 2016 Category: Cardiology Authors: Aspberg, S., Chang, Y., Atterman, A., Bottai, M., Go, A. S., Singer, D. E. Tags: Prevention and epidemiology Source Type: research

The search for the ideal atrial fibrillation stroke risk prediction schema: is ATRIA a contender?
Source: European Heart Journal - November 16, 2016 Category: Cardiology Authors: Cairns, J. A. Tags: Editorial Source Type: research

Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: analysis of the CHARM-Preserved and I-Preserve trials
Conclusions</div>A small number of clinical variables identify a subset of patients with HF-PEF, but without AF, at elevated risk of stroke.</span>
Source: European Heart Journal - November 12, 2016 Category: Cardiology Source Type: research

Catheter-based interventions for acute ischaemic stroke
currently include clot removal (usually from the medial cerebral artery) with modern stent-retrievers and in one of five patients (who have simultaneous or stand-alone internal carotid occlusion) also extracranial carotid intervention. Several recently published randomized trials clearly demonstrated superiority of catheter-based interventions (with or without bridging thrombolysis) over best medical therapy alone. The healthcare systems should adopt the new strategies for acute stroke treatment (including fast track to interventional lab) to offer the benefits to all suitable acute stroke patients.
Source: European Heart Journal - October 27, 2016 Category: Cardiology Authors: Widimsky, P., Hopkins, L. N. Tags: Frontiers in cardiovascular medicine Source Type: research

Sonolysis in Prevention of Brain Infarction During Carotid Endarterectomy and Stenting (SONOBUSTER): a randomized, controlled trial
Conclusion This study provides Class II evidence that sonolysis during CEA or CAS reduces the risk of new brain ischaemic lesions. Clinical Trial Registration http://www.clinicaltrials.gov (NCT01591005).
Source: European Heart Journal - October 27, 2016 Category: Cardiology Authors: Skoloudik, D., Kuliha, M., Hrbac, T., Jonszta, T., Herzig, R., for the SONOBUSTER Trial Group, Roubec, Hurtikova, Bar, Goldirova, Otahal, Prochazka, Czerny, Krajca, Havelka, Sanak, Kral, Netuka, Kesnerova, Langova Tags: Vascular medicine Source Type: research

Brockenbrough-Braunwald-Morrow sign
<span class="paragraphSection">A 56-year-old man presented with mild exertional dyspnea for one year. Cardiac auscultation noted a grade 3 ejection murmur at lower left sternal border which became louder and shorter (early systolic) after a premature contraction (<span style="font-style:italic;">Panel A</span>, arrow). 2D echocardiogram revealed a marked asymmetric septal hypertrophy (<span style="font-style:italic;">Panel B</span>), and a systolic anterior motion (SAM) of mitral valve and midsystolic closure (MSC) of aortic valve were detected in the postextrasystolic beat (<span style="fo...
Source: European Heart Journal - October 24, 2016 Category: Cardiology Source Type: research

Racing against time in acute ischaemic stroke treatment
Source: European Heart Journal - October 17, 2016 Category: Cardiology Tags: CardioPulse Source Type: research

The 'obesity paradox in atrial fibrillation: observations from the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial
Conclusion In patients with AF treated with oral anticoagulants, higher BMI and WC are associated with a more favourable prognosis.
Source: European Heart Journal - October 17, 2016 Category: Cardiology Authors: Sandhu, R. K., Ezekowitz, J., Andersson, U., Alexander, J. H., Granger, C. B., Halvorsen, S., Hanna, M., Hijazi, Z., Jansky, P., Lopes, R. D., Wallentin, L. Tags: Atrial fibrillation Source Type: research

Ischaemic and haemorrhagic stroke associated with non-vitamin K antagonist oral anticoagulants and warfarin use in patients with atrial fibrillation: a nationwide cohort study
Conclusions</div>Among anticoagulant-naïve AF patients, treatment with NOACs was not associated with significantly lower risk of stroke/TE compared with VKA, but intracranial bleeding risk was significantly lower with dabigatran and apixaban.</span>
Source: European Heart Journal - October 14, 2016 Category: Cardiology Source Type: research

A frameshift deletion in the sarcomere gene MYL4 causes early-onset familial atrial fibrillation
Conclusions</div>Through a population approach we found a loss of function mutation in the myosin gene <span style="font-style:italic;">MYL4</span> that, in the homozygous state, is completely penetrant for early-onset AF. The finding may provide novel mechanistic insight into the pathophysiology of this complex arrhythmia.</span>
Source: European Heart Journal - October 13, 2016 Category: Cardiology Source Type: research

Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT)
This study excluded an increased risk of the primary endpoint of more than two events per 1000 patient-years associated with switching to prescribed celecoxib.Clinical Trial Registrationhttps://clinicaltrials.gov/show/NCT00447759; Unique identifier: NCT00447759.
Source: European Heart Journal - October 4, 2016 Category: Cardiology Source Type: research

Specific risk of atrial fibrillation and stroke in oncology patients
Source: European Heart Journal - September 29, 2016 Category: Cardiology Authors: Zamorano, J. L. Tags: CardioPulse Source Type: research

Aortic valve replacement with mechanical vs. biological prostheses in patients aged 50-69 years
Conclusion Patients aged 50–69 years who received mechanical valves had better long-term survival after AVR than those with bioprostheses. The risk of stroke was similar; however, patients with bioprostheses had a higher risk of aortic valve reoperation and a lower risk of major bleeding. Clinical Trial Registration http://clinicaltrials.gov/show/NCT02276950. ClinicalTrials.gov Identifier NCT02276950.
Source: European Heart Journal - September 20, 2016 Category: Cardiology Authors: Glaser, N., Jackson, V., Holzmann, M. J., Franco-Cereceda, A., Sartipy, U. Tags: Cardiovascular surgery Source Type: research

Left atrial appendage occlusion: rationale, evidence, devices, and patient selection
<span class="paragraphSection">Atrial fibrillation (AF) is a worldwide epidemic associated with significant morbidity and mortality, often due to disabling or fatal thromboembolic stroke. Oral anticoagulation is highly effective at preventing ischaemic stroke and improving all-cause survival in patients with non-valvular AF. Despite the efficacy of oral anticoagulation, many patients are not treated due to either absolute or perceived contraindications to therapy, including bleeding. Left atrial appendage (LAA) closure has emerged as a mechanical alternative to pharmacologic stroke prevention. Initial and mid-term cl...
Source: European Heart Journal - September 14, 2016 Category: Cardiology Source Type: research