• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: the STOP-HF randomized Phase II trial
Conclusions The blinded placebo-controlled STOP-HF trial demonstrated the safety of a single endocardial administration of pSDF-1 but failed to demonstrate its primary endpoint of improved composite score at 4 months after treatment. Through a pre-specified analysis the STOP-HF trial demonstrates the potential for attenuating LV remodelling and improving EF in high-risk ischaemic cardiomyopathy. The safety profile supports repeat dosing with pSDF-1 and the degree of left ventricular remodelling suggests the potential for improved outcomes in larger future trials.
Source: European Heart Journal - September 1, 2015 Category: Cardiology Authors: Chung, E. S., Miller, L., Patel, A. N., Anderson, R. D., Mendelsohn, F. O., Traverse, J., Silver, K. H., Shin, J., Ewald, G., Farr, M. J., Anwaruddin, S., Plat, F., Fisher, S. J., AuWerter, A. T., Pastore, J. M., Aras, R., Penn, M. S. Tags: Heart failure/cardiomyopathy Source Type: research

Persistent stem cell-driven inflammation in patients with prior MI and stroke
<span class="paragraphSection"><strong><a href="article.aspx?volume=&page="><strong>This editorial refers to ‘Increased haematopoietic activity in patients with atherosclerosis’†^†, by F.M. van der Valk <span style="font-style:italic;">et al</span>., on page 425.</strong><span></span></a></strong></span>
Source: European Heart Journal - July 27, 2016 Category: Cardiology Source Type: research

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
ConclusionVascular rejuvenation using telomerase mRNA is a promising approach for progeria and other age-related diseases.
Source: European Heart Journal - August 14, 2021 Category: Cardiology Source Type: research