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Reperfusion therapy of acute ischaemic stroke and acute myocardial infarction: similarities and differences
The evolution of reperfusion therapy in acute myocardial infarction and acute ischaemic stroke has many similarities: thrombolysis is superior to placebo, intra-arterial thrombolysis is not superior to intravenous (i.v.), facilitated intervention is of questionable value, and direct mechanical recanalization without thrombolysis is proven (myocardial infarction) or promising (stroke) to be superior to thrombolysis—but only when started with no or minimal delay. However, there are also substantial differences. Direct catheter-based thrombectomy in acute ischaemic stroke is more difficult than primary angioplasty (in S...
Source: European Heart Journal - January 14, 2014 Category: Cardiology Authors: Widimsky, P., Coram, R., Abou-Chebl, A. Tags: ESC 2013 Andreas Gr[uuml ]ntzig Lecture Source Type: research

Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention
Conclusion Remote ischaemic conditioning before primary percutaneous coronary intervention seemed to improve long-term clinical outcomes in patients with ST-elevation myocardial infarction.
Source: European Heart Journal - January 14, 2014 Category: Cardiology Authors: Sloth, A. D., Schmidt, M. R., Munk, K., Kharbanda, R. K., Redington, A. N., Schmidt, M., Pedersen, L., Sorensen, H. T., Botker, H. E., CONDI Investigators Tags: FASTTRACK CLINICAL RESEARCH Source Type: research

Does remote ischaemic preconditioning with postconditioning improve clinical outcomes of patients undergoing cardiac surgery? Remote Ischaemic Preconditioning with Postconditioning Outcome Trial
Conclusion Remote ischaemic preconditioning with RIPostC by transient upper limb ischaemia did not improve clinical outcome in patients who underwent cardiac surgery. Clinical Trial Registration clinicaltrials.gov, NCT00997217.
Source: European Heart Journal - January 14, 2014 Category: Cardiology Authors: Hong, D. M., Lee, E.-H., Kim, H. J., Min, J. J., Chin, J.-H., Choi, D.-K., Bahk, J.-H., Sim, J.-Y., Choi, I.-C., Jeon, Y. Tags: Acute coronary syndromes Source Type: research

Angiopoietin-like 4 and ischaemic stroke: a promising start
Source: European Heart Journal - December 14, 2013 Category: Cardiology Authors: Spescha, R. D., Sessa, M., Camici, G. G. Tags: EDITORIALS Source Type: research

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke
Conclusion These results, therefore, show ANGPTL4 counteracts the loss of vascular integrity in ischaemic stroke, by restricting Src kinase signalling downstream from VEGFR2. ANGPTL4 treatment thus reduces oedema, infarct size, neuronal loss, and improves mice behaviour. These results suggest that ANGPTL4 constitutes a relevant target for vasculoprotection and cerebral protection during stroke.
Source: European Heart Journal - December 14, 2013 Category: Cardiology Authors: Bouleti, C., Mathivet, T., Coqueran, B., Serfaty, J.-M., Lesage, M., Berland, E., Ardidie-Robouant, C., Kauffenstein, G., Henrion, D., Lapergue, B., Mazighi, M., Duyckaerts, C., Thurston, G., Valenzuela, D. M., Murphy, A. J., Yancopoulos, G. D., Monnot, C Tags: BASIC SCIENCE Source Type: research

Patent foramen ovale transcatheter closure vs. medical therapy on recurrent vascular events: a systematic review and meta-analysis of randomized controlled trials
Conclusion These results suggest that in patients with cryptogenic stroke, TC PFO closure may be beneficial in reducing the risk of recurrent vascular events when compared to medical treatment. The benefit of TC PFO closure may be greater in patients with a substantial shunt.
Source: European Heart Journal - November 14, 2013 Category: Cardiology Authors: Rengifo-Moreno, P., Palacios, I. F., Junpaparp, P., Witzke, C. F., Morris, D. L., Romero-Corral, A. Tags: International cardiology Source Type: research

Long-term results of a randomized trial comparing three different devices for percutaneous closure of a patent foramen ovale
Conclusion Although procedural complications and long-term neurological event rates are low regardless of the device used, the recurrent neurological event rate was significantly lower after Amplatzer than after CardioSEAL-STARflex or Helex implantation. This has important implications regarding the interpretation of trials comparing PFO closure with medical management.
Source: European Heart Journal - November 14, 2013 Category: Cardiology Authors: Hornung, M., Bertog, S. C., Franke, J., Id, D., Taaffe, M., Wunderlich, N., Vaskelyte, L., Hofmann, I., Sievert, H. Tags: Interventional cardiology Source Type: research

The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk
Conclusions These findings suggest that CAD/MI-associated risk alleles play an aetiological role in different types of atherosclerotic disease.
Source: European Heart Journal - October 1, 2013 Category: Cardiology Authors: Tragante, V., Doevendans, P. A. F. M., Nathoe, H. M., van der Graaf, Y., Spiering, W., Algra, A., de Borst, G. J., de Bakker, P. I. W., Asselbergs, F. W., on behalf of the SMART study group Tags: Coronary artery disease Source Type: research

Secondary prevention by stroke subtype: a nationwide follow-up study in 46 108 patients after acute ischaemic stroke
Conclusions Our study demonstrated that stroke subtype affects prognosis and also determines the effectiveness of secondary prevention.
Source: European Heart Journal - September 14, 2013 Category: Cardiology Authors: Kim, D., Lee, S.-H., Joon Kim, B., Jung, K.-H., Yu, K.-H., Lee, B.-C., Roh, J.-K., for Korean Stroke Registry investigators Tags: Atrial fibrillation Source Type: research

Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography
Conclusion A novel urinary inflammation marker, KTR, is strongly associated with adverse prognosis in patients with suspected stable CAD. Underlying pathomechanisms should be further elucidated.
Source: European Heart Journal - September 7, 2013 Category: Cardiology Authors: Pedersen, E. R., Svingen, G. F. T., Schartum-Hansen, H., Ueland, P. M., Ebbing, M., Nordrehaug, J. E., Igland, J., Seifert, R., Nilsen, R. M., Nygard, O. Tags: Coronary artery disease Source Type: research

Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial
Conclusion The risks of stroke, mortality, and major bleeding were lower with apixaban than warfarin regardless of AF type and duration. Although the risk of stroke or systemic embolism was lower in paroxysmal than persistent or permanent AF, apixaban is an attractive alternative to warfarin in patients with AF and at least one other risk factor for stroke, regardless of the type or duration of AF.
Source: European Heart Journal - August 14, 2013 Category: Cardiology Authors: Al-Khatib, S. M., Thomas, L., Wallentin, L., Lopes, R. D., Gersh, B., Garcia, D., Ezekowitz, J., Alings, M., Yang, H., Alexander, J. H., Flaker, G., Hanna, M., Granger, C. B. Tags: Arrhythmia/electrophysiology Source Type: research

New oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome: a systematic review and meta-analysis
Conclusion In patients with a recent acute coronary syndrome, the addition of a new oral anticoagulant to antiplatelet therapy results in a modest reduction in cardiovascular events but a substantial increase in bleeding, most pronounced when new oral anticoagulants are combined with dual antiplatelet therapy.
Source: European Heart Journal - June 7, 2013 Category: Cardiology Authors: Oldgren, J., Wallentin, L., Alexander, J. H., James, S., Jonelid, B., Steg, G., Sundstrom, J. Tags: Acute coronary syndromes Source Type: research

Urgent surgery compared with fibrinolytic therapy for the treatment of left-sided prosthetic heart valve thrombosis: a systematic review and meta-analysis of observational studies
Conclusion Urgent surgery was not superior to FT at restoring valve function, but substantially reduced the occurrence of thrombo-embolic events, major bleeding, and recurrent PVT. In experienced centres, urgent surgery should probably be preferred over FT for treating left-sided PVT, pending the results of randomized controlled trials.
Source: European Heart Journal - June 1, 2013 Category: Cardiology Authors: Karthikeyan, G., Senguttuvan, N. B., Joseph, J., Devasenapathy, N., Bahl, V. K., Airan, B. Tags: Valvular heart disease Source Type: research

Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)
Conclusion Betrixaban was well tolerated and had similar or lower rates of bleeding compared with well-controlled warfarin in patients with AF at risk for stroke.
Source: European Heart Journal - May 21, 2013 Category: Cardiology Authors: Connolly, S. J., Eikelboom, J., Dorian, P., Hohnloser, S. H., Gretler, D. D., Sinha, U., Ezekowitz, M. D. Tags: Arrhythmia/electrophysiology Source Type: research

Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC Study
Conclusions In this Japanese population, SFAs intake was inversely associated with deep intraparenchymal haemorrhage and lacunar infarction and positively associated with myocardial infarction.
Source: European Heart Journal - April 21, 2013 Category: Cardiology Authors: Yamagishi, K., Iso, H., Kokubo, Y., Saito, I., Yatsuya, H., Ishihara, J., Inoue, M., Tsugane, S., for the JPHC Study Group, Sobue, Hanaoka, Ogata, Baba, Mannami, Okayama, K., Miyakawa, Saito, Koizumi, Sano, Hashimoto, Ikuta, Tanaba, Miyajima, Suzuki, Naga Tags: Prevention and epidemiology Source Type: research

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