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Short-Term Change in eGFR and Risk of Cardiovascular Events Health Services and Outcomes Research
Conclusion Clinically relevant changes in eGFR are associated with increased risk of cardiovascular events. However, most of the apparent increase in risk can be accounted for by assessing comorbidity and baseline kidney function.
Source: JAHA:Journal of the American Heart Association - September 11, 2014 Category: Cardiology Authors: Turin, T. C., James, M. T., Jun, M., Tonelli, M., Coresh, J., Manns, B. J., Hemmelgarn, B. R. Tags: Health Services and Outcomes Research Source Type: research

Importance of Exercise Capacity in Predicting Outcomes and Determining Optimal Timing of Surgery in Significant Primary Mitral Regurgitation Valvular Heart Disease
Conclusion In patients with primary MR that underwent exercise echocardiography followed by MV surgery, lower achieved metabolic equivalents were associated with worse long-term outcomes. In those with preserved exercise capacity, delaying MV surgery by ≥1 year did not adversely affect outcomes.
Source: JAHA:Journal of the American Heart Association - September 11, 2014 Category: Cardiology Authors: Naji, P., Griffin, B. P., Barr, T., Asfahan, F., Gillinov, A. M., Grimm, R. A., Rodriguez, L. L., Mihaljevic, T., Stewart, W. J., Desai, M. Y. Tags: Valvular Heart Disease Source Type: research

Impact of Heme and Heme Degradation Products on Vascular Diameter in Mouse Visual Cortex Stroke
Conclusions We identified individual components of the oxidative bilirubin degradation that led to vasoconstriction of cerebral arterioles. The vasoconstrictive effect of Z-BOX A and Z-BOX B was mediated by BKCa channel activity that might represent a signaling pathway in the occurrence of delayed cerebral vasospasm in subarachnoid hemorrhage patients.
Source: JAHA:Journal of the American Heart Association - August 28, 2014 Category: Cardiology Authors: Joerk, A., Seidel, R. A., Walter, S. G., Wiegand, A., Kahnes, M., Klopfleisch, M., Kirmse, K., Pohnert, G., Westerhausen, M., Witte, O. W., Holthoff, K. Tags: Stroke Source Type: research

Contemporary Management of Atrial Fibrillation: What Can Clinical Registries Tell Us About Stroke Prevention and Current Therapeutic Approaches? Contemporary Reviews
Source: JAHA:Journal of the American Heart Association - August 27, 2014 Category: Cardiology Authors: Lip, G. Y. H., Al-Khatib, S. M., Cosio, F. G., Banerjee, A., Savelieva, I., Ruskin, J., Blendea, D., Nattel, S., De Bono, J., Conroy, J. M., Hess, P. L., Guasch, E., Halperin, J. L., Kirchhof, P., G. Cosio, M. D., Camm, A. J. Tags: Contemporary Reviews Source Type: research

Obesity, Physical Activity, and Their Interaction in Incident Atrial Fibrillation in Postmenopausal Women Arrhythmia and Electrophysiology
Conclusions Greater physical activity is associated with lower rates of incident AF and modifies the association between obesity and incident AF.
Source: JAHA:Journal of the American Heart Association - August 20, 2014 Category: Cardiology Authors: Azarbal, F., Stefanick, M. L., Salmoirago-Blotcher, E., Manson, J. E., Albert, C. M., LaMonte, M. J., Larson, J. C., Li, W., Martin, L. W., Nassir, R., Garcia, L., Assimes, T. L., Tharp, K. M., Hlatky, M. A., Perez, M. V. Tags: Arrhythmia and Electrophysiology Source Type: research

Choosing Wisely for Syncope: Low-Value Carotid Ultrasound Use Health Services and Outcomes Research
Conclusions These data suggest that carotid ultrasound for patients with uncomplicated syncope are still commonly ordered and may be an easy target for institutions striving to curtail low-value care.
Source: JAHA:Journal of the American Heart Association - August 13, 2014 Category: Cardiology Authors: Scott, J. W., Schwartz, A. L., Gates, J. D., Gerhard-Herman, M., Havens, J. M. Tags: Health Services and Outcomes Research Source Type: research

Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification and Vascular Territory of Ischemic Stroke Lesions Diagnosed by Diffusion-Weighted Imaging Stroke
Conclusions Information on vascular territory of a stroke lesion may be helpful in timely investigation and accurate diagnosis of stroke etiology.
Source: JAHA:Journal of the American Heart Association - August 11, 2014 Category: Cardiology Authors: Chung, J.-W., Park, S. H., Kim, N., Kim, W.-J., Park, J. H., Ko, Y., Yang, M. H., Jang, M. S., Han, M.-K., Jung, C., Kim, J. H., Oh, C. W., Bae, H.-J. Tags: Stroke Source Type: research

Short-term Changes in Ambient Particulate Matter and Risk of Stroke: A Systematic Review and Meta-analysis Stroke
Conclusions We found that PM2.5 and PM10 are associated with a 1.4% (95% CI 0.9% to 1.9%) and 0.5% (95% CI 0.3% to 0.7%) higher total cerebrovascular disease mortality, respectively, with evidence of inconsistent, nonsignificant associations for hospital admission for total cerebrovascular disease or ischemic or hemorrhagic stroke. Current limited evidence does not suggest an association between PM2.5-10 and cerebrovascular mortality or morbidity. We discuss the potential sources of variability in results across studies, highlight some observations, and identify gaps in literature and make recommendations for future studies.
Source: JAHA:Journal of the American Heart Association - August 7, 2014 Category: Cardiology Authors: Wang, Y., Eliot, M. N., Wellenius, G. A. Tags: Stroke Source Type: research

Prognostic Implications of Left Ventricular Dyssynchrony for Major Adverse Cardiovascular Events in Asymptomatic Women and Men: The Multi-Ethnic Study of Atherosclerosis Heart Failure
Conclusions In an asymptomatic cohort, greater LV dyssynchrony determined by cardiac magnetic resonance imaging predicts adverse cardiovascular outcome in women but not in men. Clinical Trial Registration URL: http://clinicaltrials.gov. Unique identifier: NCT00005487.
Source: JAHA:Journal of the American Heart Association - August 4, 2014 Category: Cardiology Authors: Sharma, R. K., Volpe, G., Rosen, B. D., Ambale-Venkatesh, B., Donekal, S., Fernandes, V., Wu, C. O., Carr, J., Bluemke, D. A., Lima, J. A. C. Tags: Heart Failure Source Type: research

B-type Natriuretic Peptides for the Prediction of Cardiovascular Events in Patients With Stable Coronary Heart Disease: The Heart and Soul Study Coronary Heart Disease
Conclusions Both BNP and NT-proBNP were significant predictors of MACE in stable coronary heart disease; however, NT-proBNP was superior to BNP for net risk reclassification for MACE.
Source: JAHA:Journal of the American Heart Association - July 22, 2014 Category: Cardiology Authors: Mishra, R. K., Beatty, A. L., Jaganath, R., Regan, M., Wu, A. H. B., Whooley, M. A. Tags: Coronary Heart Disease Source Type: research

Adult Moyamoya Disease in an Urban Center in the United States Is Associated With a High Burden of Watershed Ischemia Stroke
Conclusions We observed a high burden of ischemia, mostly watershed pattern on neuroimaging in our adult moyamoya disease patients. Long-term monitoring of adult moyamoya disease patients in the United States would be useful to better understand the natural history of this condition.
Source: JAHA:Journal of the American Heart Association - July 18, 2014 Category: Cardiology Authors: Zafar, S. F., Bershad, E. M., Gildersleeve, K. L., Newmark, M. E., Calvillo, E., Suarez, J. I., Venkatasubba Rao, C. P. Tags: Stroke Source Type: research

Socioeconomic Position and Incidence of Ischemic Stroke in Denmark 2003-2012. A Nationwide Hospital-Based Study Stroke
Conclusions In Denmark, there is a strong relation between low socioeconomic position and risk for hospitalization for stroke. Lifestyle, as indicated by smoking, obesity, and alcohol consumption, and diabetes appears to increase the risk for stroke in people with lower socioeconomic position.
Source: JAHA:Journal of the American Heart Association - July 16, 2014 Category: Cardiology Authors: Andersen, K. K., Steding-Jessen, M., Dalton, S. O., Olsen, T. S. Tags: Stroke Source Type: research

The Impact of Acute Kidney Injury on the Long-term Risk of Stroke Kidney in Cardiovascular Disease
Conclusions The patients who recovered from AKI had a higher incidence of developing incident stroke and mortality than the patients without AKI, and the impact was similar to diabetes. Our results suggest that a public health initiative is needed to enhance postdischarge follow-up of renal function and to control the subsequent incidence of stroke among patients who recover from AKI after dialysis.
Source: JAHA:Journal of the American Heart Association - July 15, 2014 Category: Cardiology Authors: Wu, V.-C., Wu, P.-C., Wu, C.-H., Huang, T.-M., Chang, C.-H., Tsai, P.-R., Ko, W.-J., Chen, L., Wang, C.-Y., Chu, T.-S., Wu, K.-D., The National Taiwan University Study Group on Acute Renal Failure (NSARF) Group Tags: Kidney in Cardiovascular Disease Source Type: research

Incremental Prognostic Significance of the Elevated Levels of Pentraxin 3 in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction Heart Failure
Conclusions High plasma PTX3 levels, but not other inflammatory markers, are correlated with future cardiovascular events in patients with HFNEF. PTX3 may be a useful biomarker for assessment of risk stratification in HFNEF. Clinical Trial Registration URL: http://www.umin.ac.jp; Unique identifier: UMIN000002170.
Source: JAHA:Journal of the American Heart Association - July 10, 2014 Category: Cardiology Authors: Matsubara, J., Sugiyama, S., Nozaki, T., Akiyama, E., Matsuzawa, Y., Kurokawa, H., Maeda, H., Fujisue, K., Sugamura, K., Yamamoto, E., Matsui, K., Jinnouchi, H., Ogawa, H. Tags: Heart Failure Source Type: research

Reduction in Overall Occurrences of Ischemic Events With Vorapaxar: Results From TRACER Coronary Heart Disease
Conclusions Vorapaxar reduced overall occurrences of ischemic events, but increased bleeding. These exploratory findings broaden our understanding of vorapaxar's potential and expand our understanding of the value of capturing recurrent events. Clinical Trial Registration URL: ClinicalTrials.gov. Unique identifier: NCT00527943.
Source: JAHA:Journal of the American Heart Association - July 10, 2014 Category: Cardiology Authors: White, H. D., Huang, Z., Tricoci, P., Van de Werf, F., Wallentin, L., Lokhnygina, Y., Moliterno, D. J., Aylward, P. E., Mahaffey, K. W., Armstrong, P. W. Tags: Coronary Heart Disease Source Type: research

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