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Secondary prevention and cognitive function after stroke: a study protocol for a 5-year follow-up of the ASPIRE-S cohort
Introduction Cognitive impairment is common following stroke and can increase disability and levels of dependency of patients, potentially leading to greater burden on carers and the healthcare system. Effective cardiovascular risk factor control through secondary preventive medications may reduce the risk of cognitive decline. However, adherence to medications is often poor and can be adversely affected by cognitive deficits. Suboptimal medication adherence negatively impacts secondary prevention targets, increasing the risk of recurrent stroke and further cognitive decline. The aim of this study is to profile cognitive f...
Source: BMJ Open - March 27, 2017 Category: Journals (General) Authors: Rohde, D., Williams, D., Gaynor, E., Bennett, K., Dolan, E., Callaly, E., Large, M., Hickey, A. Tags: Open access, Cardiovascular medicine, Epidemiology Protocol Source Type: research

Adverse outcomes after total and unicompartmental knee replacement in 101 330 matched patients: a study of data from the National Joint Registry for England and Wales
Publication date: 18–24 October 2014 Source:The Lancet, Volume 384, Issue 9952 Author(s): Alexander D Liddle , Andrew Judge , Hemant Pandit , David W Murray Background Total knee replacement (TKR) or unicompartmental knee replacement (UKR) are options for end-stage osteoarthritis. However, comparisons between the two procedures are confounded by differences in baseline characteristics of patients undergoing either procedure and by insufficient reporting of endpoints other than revision. We aimed to compare adverse outcomes for each procedure in matched patients. Methods With propensity score techniques, we compared ma...
Source: The Lancet - October 17, 2014 Category: Journals (General) Source Type: research