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Source: Circulation Research
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Total 78 results found since Jan 2013.

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: A Meta-Analysis of Population-Based Studies Involving 17,180 Individuals.
CONCLUSIONS: Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1-signaling might represent a therapeutic target to lower stroke risk. PMID: 31476962 [PubMed - as supplied by publisher]
Source: Circulation Research - September 2, 2019 Category: Cardiology Authors: Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt MS, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Söderholm M, Wareham N, Ballantyne CM, Tags: Circ Res Source Type: research

Cryptogenic Stroke: Research and Practice.
CONCLUSIONS: A thorough diagnostic evaluation is essential to determine the pathogenesis in cryptogenic stroke. This approach, in addition to risk factor management and lifestyle modifications, will lead to improved stroke prevention strategies in patients with cryptogenic stroke. This will allow for targeted clinical trials to improve stroke prevention strategies in this patient population. PMID: 28154102 [PubMed - in process]
Source: Circulation Research - February 2, 2017 Category: Cardiology Authors: Yaghi S, Bernstein RA, Passman R, Okin PM, Furie KL Tags: Circ Res Source Type: research

Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice.
Conclusions:This is the first study suggesting that the poor stroke recovery in aged mice can be reversed via "post-stroke bacteriotherapy" following the replenishment of youthful gut microbiome via modulation of immunologic, microbial and metabolomic profiles in the host. PMID: 32354259 [PubMed - as supplied by publisher]
Source: Circulation Research - April 30, 2020 Category: Cardiology Authors: Lee J, d'Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino JF, Putluri N, Zhu L, Durgan DJ, Bryan RM, McCullough LD, Venna VR Tags: Circ Res Source Type: research

Targeting Myeloid-Specific Integrin α9β1 Improves Short and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis And Inflammation.
Conclusions: We provide genetic and pharmacologic evidence for the first time that targeting myeloid-specific integrin α9β1 improves short and long-term functional outcome in stroke models with preexisting comorbidities by limiting cerebral thrombosis and inflammation. PMID: 32195632 [PubMed - as supplied by publisher]
Source: Circulation Research - March 19, 2020 Category: Cardiology Authors: Dhanesha N, Jain M, Tripathi A, Doddapattar P, Chorawala M, Bathla G, Nayak MK, Ghatge M, Lentz SR, Kon S, Chauhan AK Tags: Circ Res Source Type: research

High-Density Lipoprotein Carries Markers that Track with Recovery from Stroke.
Conclusions: Changes in HDL proteins during early acute phase of stroke associate with recovery. Monitoring HDL proteins may provide clinical biomarkers that inform on stroke recuperation . PMID: 32844720 [PubMed - as supplied by publisher]
Source: Circulation Research - August 25, 2020 Category: Cardiology Authors: Plubell DL, Fenton AM, Rosario S, Bergstrom P, Wilmarth PA, Clark WM, Zakai N, Quinn JF, Minnier J, Alkayed NJ, Fazio S, Pamir N Tags: Circ Res Source Type: research

Inflammatory Disequilibrium in Stroke.
Abstract Over the past several decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to the development of thrombolytic therapy as the cornerstone of current management of ischemic stroke, but there remains much to be learned about mechanisms of neuronal ischemic and reperfusion injury and associated inflammation. For ischemic stroke, novel therapeutic targets have continued to remain elusive. When considering modern molecular biological techniques, advanced translational stroke models, and clinical studies, a consi...
Source: Circulation Research - June 23, 2016 Category: Cardiology Authors: Petrovic-Djergovic D, Goonewardena SN, Pinsky DJ Tags: Circ Res Source Type: research

Global Burden of Stroke.
Abstract On the basis of the GBD (Global Burden of Disease) 2013 Study, this article provides an overview of the global, regional, and country-specific burden of stroke by sex and age groups, including trends in stroke burden from 1990 to 2013, and outlines recommended measures to reduce stroke burden. It shows that although stroke incidence, prevalence, mortality, and disability-adjusted life-years rates tend to decline from 1990 to 2013, the overall stroke burden in terms of absolute number of people affected by, or who remained disabled from, stroke has increased across the globe in both men and women of all ag...
Source: Circulation Research - February 2, 2017 Category: Cardiology Authors: Feigin VL, Norrving B, Mensah GA Tags: Circ Res Source Type: research

Post-Stroke Cognitive Impairment and Dementia
Circ Res. 2022 Apr 15;130(8):1252-1271. doi: 10.1161/CIRCRESAHA.122.319951. Epub 2022 Apr 14.ABSTRACTPoststroke cognitive impairment and dementia (PSCID) is a major source of morbidity and mortality after stroke worldwide. PSCID occurs as a consequence of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Cognitive impairment and dementia manifesting after a clinical stroke is categorized as vascular even in people with comorbid neurodegenerative pathology, which is common in elderly individuals and can contribute to the clinical expression of PSCID. Manifestations of cerebral small vessel disease, such...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Natalia S Rost Amy Brodtmann Matthew P Pase Susanne J van Veluw Alessandro Biffi Marco Duering Jason D Hinman Martin Dichgans Source Type: research

Attenuation of Myeloid Specific TGF β Signaling Induces Inflammatory Cerebrovascular Disease and Stroke.
Conclusions: Our studies show that TGFβ signaling in myeloid cells is required for maintenance of vascular health, and provide insight into inflammation-mediated cerebrovascular disease and stroke. PMID: 29051340 [PubMed - as supplied by publisher]
Source: Circulation Research - October 19, 2017 Category: Cardiology Authors: Hollander MC, Latour LL, Yang D, Ishii H, Xiao Z, Min Y, Ray-Choudhury A, Munasinghe J, Merchant AS, Lin PC, Hallenbeck J, Boehm M, Yang L Tags: Circ Res Source Type: research

Evolving Treatments for Acute Ischemic Stroke.
We describe how stroke presents as a clinical syndrome and how imaging as the most important biomarker will help differentiate between stroke subtypes and treatment eligibility. The evolution of hyperacute treatment has led to the current standard of care: intravenous thrombolysis with tissue-type plasminogen activator and endovascular treatment for proximal vessel occlusion in the anterior cerebral circulation. All patients with acute ischemic stroke are in need of hyperacute secondary prevention because the risk of recurrence is highest closest to the index event. The dominant themes of modern stroke care are the use of ...
Source: Circulation Research - April 28, 2016 Category: Cardiology Authors: Zerna C, Hegedus J, Hill MD Tags: Circ Res Source Type: research

Acute Ischemic Stroke Therapy Overview.
Abstract The treatment of acute ischemic stroke has undergone dramatic changes recently subsequent to the demonstrated efficacy of intra-arterial (IA) device-based therapy in multiple trials. The selection of patients for both intravenous and IA therapy is based on timely imaging with either computed tomography or magnetic resonance imaging, and if IA therapy is considered noninvasive, angiography with one of these modalities is necessary to document a large-vessel occlusion amenable for intervention. More advanced computed tomography and magnetic resonance imaging studies are available that can be used to identif...
Source: Circulation Research - February 2, 2017 Category: Cardiology Authors: Catanese L, Tarsia J, Fisher M Tags: Circ Res Source Type: research

Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome
Circ Res. 2022 Apr 15;130(8):1112-1144. doi: 10.1161/CIRCRESAHA.122.319983. Epub 2022 Apr 14.ABSTRACTThe microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and their host. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional and functional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses to disease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability of microbiota and its host to restore a symbiotic state. Dysbiosis leads to d...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Pedram Honarpisheh Robert M Bryan Louise D McCullough Source Type: research